GB881627A - N-(ú=-chlorobenzenesulphonyl)-n-(ú=-dimethylaminophenyl) urea, and its preparation - Google Patents

N-(ú=-chlorobenzenesulphonyl)-n-(ú=-dimethylaminophenyl) urea, and its preparation

Info

Publication number
GB881627A
GB881627A GB40077/59A GB4007759A GB881627A GB 881627 A GB881627 A GB 881627A GB 40077/59 A GB40077/59 A GB 40077/59A GB 4007759 A GB4007759 A GB 4007759A GB 881627 A GB881627 A GB 881627A
Authority
GB
United Kingdom
Prior art keywords
dimethylaminophenyl
urea
chlorobenzenesulphonyl
preparation
alkali
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB40077/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Priority to GB40077/59D priority Critical patent/GB922696A/en
Priority to FR844600A priority patent/FR1280670A/en
Priority to CH1306760A priority patent/CH383040A/en
Priority to DEN19238A priority patent/DE1183283B/en
Publication of GB881627A publication Critical patent/GB881627A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises: N-(p-chlorobenzenesulphonyl)-N1-(p-dimethylaminophenyl) -urea and its alkali metal salts; pharmaceutical compositions containing them (see Group VI); and the preparation of N-(p-chlorobenzenesulphonyl)-N1-(p-dimethylaminophenyl)-urea by reacting p-chlorobenzenesulphonamide, or an alkali metal salt thereof, with p-dimethylaminophenyl isocyanate, or with an N,N-diaryl-N1-(p-dimethylaminophenyl)-urea, or with an aryl-N-(p-dimethylaminophenyl)-carbamate or -thiocarbamate. Other standard methods of preparation are also outlined. p-Chlorobenzenesulphonamide may be prepared by ammonolysis of the corresponding sulphochloride, and may be converted into alkali or alkaline-earth metal salts by the action of basic alkali and alkaline-earth metal compounds.ALSO:Pharmaceutical compositions for the oral treatment of diabetes comprise N-(p-chlorobenzenesulphonyl) - N1 - (p - dimethylaminophenyl)-urea or an alkali metal salt thereof, in admixture with a pharmaceutically acceptable carrier or diluent. They may take the form of capsules, tablets, lozenges, troches, aqueous suspensions or elixirs.
GB40077/59A 1958-11-25 1959-11-25 N-(ú=-chlorobenzenesulphonyl)-n-(ú=-dimethylaminophenyl) urea, and its preparation Expired GB881627A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB40077/59D GB922696A (en) 1959-11-25 1959-11-25 Improvements in or relating to calculating devices
FR844600A FR1280670A (en) 1959-11-25 1960-11-22 Multiplication factor calculator with predetermined values
CH1306760A CH383040A (en) 1959-11-25 1960-11-22 Accounting facility
DEN19238A DE1183283B (en) 1959-11-25 1960-11-24 Booking or similar calculating machine with electrical constant factor multiplication

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77618558A 1958-11-25 1958-11-25

Publications (1)

Publication Number Publication Date
GB881627A true GB881627A (en) 1961-11-08

Family

ID=25106700

Family Applications (1)

Application Number Title Priority Date Filing Date
GB40077/59A Expired GB881627A (en) 1958-11-25 1959-11-25 N-(ú=-chlorobenzenesulphonyl)-n-(ú=-dimethylaminophenyl) urea, and its preparation

Country Status (3)

Country Link
DE (1) DE1283825B (en)
FR (1) FR285M (en)
GB (1) GB881627A (en)

Also Published As

Publication number Publication date
DE1283825B (en) 1968-11-28
FR285M (en) 1961-03-13

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