GB880363A - Improvements in or relating to steroid compounds - Google Patents
Improvements in or relating to steroid compoundsInfo
- Publication number
- GB880363A GB880363A GB14952/60A GB1495260A GB880363A GB 880363 A GB880363 A GB 880363A GB 14952/60 A GB14952/60 A GB 14952/60A GB 1495260 A GB1495260 A GB 1495260A GB 880363 A GB880363 A GB 880363A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cholestadiene
- cholesterone
- dehydrocholesterol
- dinitrobenzoate
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 19-nor-7-dehydrocholesterol and esters thereof such as the 3,5-dinitrobenzoate thereof, 19-nor-3-acetoxy-D 3,5,7-cholestatriene, 19-nor-D 4,6-cholestadiene-3-one and 19-nor-6-bromo-cholesterone, and a process for the preparation of 19-nor-7-dehydrocholesterol by reducing an enol ester of 19-nor-D 4,6-cholestadiene-3-one with an alkali metal borohydride. The above process may be modified in that 19-nor-D 4,6-cholestadiene-3-one from which the enol ester is produced is obtained by dehydrobrominating 6-bromo-19-nor-cholesterone e.g. by means of lithium bromide and lithium carbonate in the presence of dimethyl formomide, and the 6-bromo-19-nor-cholesterone is prepared by brominating an enol ester of 19-nor-chlosterone which may be prepared by a method described and claimed in Specification 880,362. The 19-nor-7-dehydrocholesterol prepared by the above method may be purified by converting it into its 3,5-dinitrobenzoate and then saponifying the dinitrobenzoate. The enol ester is preferably the acetic acid ester and is obtainable by the action of a mixture of acetic anhydride and acetyl chloride. 19-nor-D 4,6-cholestadiene-3-one may also be obtained by oxidising 19-nor-cholesterol with manganese dioxide. Detailed examples are given. Specification 832,244 also is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR880363X | 1957-06-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB880363A true GB880363A (en) | 1961-10-18 |
Family
ID=9364448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB14952/60A Expired GB880363A (en) | 1957-06-14 | 1958-05-21 | Improvements in or relating to steroid compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB880363A (en) |
-
1958
- 1958-05-21 GB GB14952/60A patent/GB880363A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB880363A (en) | Improvements in or relating to steroid compounds | |
| GB833183A (en) | Improvements in or relating to cyclopentanophenanthrene compounds | |
| GB397212A (en) | Improvements in the manufacture of optically active menthols | |
| US3092626A (en) | Process for the manufacture of 16-alkyl-20:21-ketols of the pregnane series | |
| GB522870A (en) | Improvements in and relating to acids of the etiocholane series | |
| GB865316A (en) | Improvements in or relating to steroids and the manufacture thereof | |
| GB669205A (en) | Process for the manufacture of esters of cholesterol and of cosmetic preparations including such esters | |
| GB899582A (en) | New cyclopentanophenanthrene derivatives and process for the production thereof | |
| GB920750A (en) | Method of producing testosterone-chloral-hemiacetals and their esters and starting materials therefor | |
| GB944321A (en) | Process for the manufacture of 11ª -hydroxy-6ª -halogen-pregnenes | |
| GB893071A (en) | Improvements in or relating to the preparation of 17-alpha-haloprogesterones and related products | |
| GB443964A (en) | The manufacture of unsaturated hydroxy-ketones related to the corpus luteum hormone | |
| GB922803A (en) | 4-hydroxy (and acyloxy)-3-keto-steroids | |
| ES248944A1 (en) | 6 --methyl-17 --hydroxyprogesterone and esters thereof and process for their preparation | |
| GB963964A (en) | Improvements in or relating to the bromination of hecogenin and esters thereof | |
| GB761526A (en) | Steroid compounds | |
| GB833184A (en) | Improvements in or relating to the production of ª‡-glycirrhetinic acid and esters thereof | |
| GB1038628A (en) | í¸-3-oxo-steroids and process for their manufacture | |
| GB351318A (en) | Improvements in or relating to the preparation of vinyl esters | |
| GB922877A (en) | New derivatives of 13-methylcyclopentanopolyhydrophenanthrene and methods for the production thereof | |
| GB379705A (en) | Improvements in or relating to the manufacture of vinyl esters | |
| GB918408A (en) | Esters of 21-hydroxy steroids and process for preparation | |
| GB952491A (en) | New steroid compounds and processes for the preparation thereof | |
| GB883310A (en) | Improvements in or relating to hormonal agents | |
| GB965928A (en) | Processes for the production of steroid compounds,and the new compounds thereby obtained |