GB922877A - New derivatives of 13-methylcyclopentanopolyhydrophenanthrene and methods for the production thereof - Google Patents
New derivatives of 13-methylcyclopentanopolyhydrophenanthrene and methods for the production thereofInfo
- Publication number
- GB922877A GB922877A GB2134359A GB2134359A GB922877A GB 922877 A GB922877 A GB 922877A GB 2134359 A GB2134359 A GB 2134359A GB 2134359 A GB2134359 A GB 2134359A GB 922877 A GB922877 A GB 922877A
- Authority
- GB
- United Kingdom
- Prior art keywords
- estradien
- propinyl
- ethoxy
- methoxy
- vinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 17-esters of 17a -alkyl, alkenyl or alkinyl-D 5(10)-estren-17b -ol-3-ones wherein the 17a -substituent contains not more than 4 carbon atoms and the esterifying acids are those of hydrocarbon carboxylic acids of up to 12 carbons which may be substituted, e.g. by methoxy or chloro, together with a process for their preparation by esterifying the corresponding 3-alkyl enol ether 17b -hydroxy compound and subsequently hydrolysing the ether group under mild acid conditions, e.g. with oxalic acid. The invention is illustrated by detailed examples. 17a -Vinyl-3-methoxy, 17a -vinyl- 3-propoxy-D 2,5(10) estradien-17b -ol are prepared by hydrogenation and 17a -propen-(1)-yl-3-ethoxy of the 17a -ethinyl (or propinyl) analogues, and 17a -propinyl -(1)-3- ethoxy-D 2,5(10)- estradien-17b -ol is obtained by treatment of the 17-oxo analogue with methylacetylene in potassium t-amylate solution. Specification 850,386 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX5137458 | 1958-06-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB922877A true GB922877A (en) | 1963-04-03 |
Family
ID=19742853
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2134359A Expired GB922877A (en) | 1958-06-25 | 1959-06-22 | New derivatives of 13-methylcyclopentanopolyhydrophenanthrene and methods for the production thereof |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE1146881B (en) |
GB (1) | GB922877A (en) |
-
1959
- 1959-06-22 GB GB2134359A patent/GB922877A/en not_active Expired
- 1959-06-24 DE DES63611A patent/DE1146881B/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE1146881B (en) | 1963-04-11 |
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