GB865341A - 5-benzene-sulphonamido-1-phenyl pyrazole derivatives - Google Patents

5-benzene-sulphonamido-1-phenyl pyrazole derivatives

Info

Publication number
GB865341A
GB865341A GB25040/59A GB2504059A GB865341A GB 865341 A GB865341 A GB 865341A GB 25040/59 A GB25040/59 A GB 25040/59A GB 2504059 A GB2504059 A GB 2504059A GB 865341 A GB865341 A GB 865341A
Authority
GB
United Kingdom
Prior art keywords
benzene
methyl
phenyl
ring
phenyl pyrazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB25040/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of GB865341A publication Critical patent/GB865341A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/42—Benzene-sulfonamido pyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems

Abstract

The invention comprises 5-benzenesulphonamido-1-phenyl pyrazoles of the formula: <FORM:0865341/IV (b)/1> wherein Ar is a benzene ring optionally bearing a C1-2 alkyl or a C1-4 alkoxy substituent and in which the 3- and /or 4- position of the pyrazole ring may be substituted by a C1-2 alkyl radical, or the 3- and 4- positions may be co-condensed with a 5- or 6- membered cycloaliphatic ring, and alkali metal salts thereof; and their preparation by treating a 5-amino-1-phenyl pyrazole with a benzenesulphonyl halide in the presence of an acid acceptor such as an organic or inorganic base, e.g. a trialkylamine, pyridine, sodium carbonate or potassium carbonate, preferably in an inert solvent or diluent such as methylene chloride, diphenyl ether, diphenyl methane, paraffin oil, tetra- and decahydronaphthalene, methyl-naphthalene, chloronaphthalene or mixtures of these diluents. Suitably Ar may be a benzene, o, m or p-methylbenzene or p-methoxy-, propoxy- or butoxy-benzene residue and the 1-phenyl pyrazole ring is unsubstituted or bears a 3-methyl, 3:4-dimethyl, 3-methyl-4-ethyl, 3:4-trimethylene or 3:4-tetramethylene substituents.
GB25040/59A 1958-07-30 1959-07-21 5-benzene-sulphonamido-1-phenyl pyrazole derivatives Expired GB865341A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE865341X 1958-07-30

Publications (1)

Publication Number Publication Date
GB865341A true GB865341A (en) 1961-04-12

Family

ID=6801823

Family Applications (1)

Application Number Title Priority Date Filing Date
GB25040/59A Expired GB865341A (en) 1958-07-30 1959-07-21 5-benzene-sulphonamido-1-phenyl pyrazole derivatives

Country Status (1)

Country Link
GB (1) GB865341A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0192951A2 (en) * 1985-02-02 1986-09-03 Bayer Ag 5-Sulfonamido-1-aryl pyrazoles
EP1698335A1 (en) * 2003-12-26 2006-09-06 Ono Pharmaceutical Co., Ltd. Preventive and/or therapeutic agent for disease in which mitochondrial benzodiazepine receptor participates
US20110112073A1 (en) * 2008-05-15 2011-05-12 Duke University Compositions and methods relating to heat shock transcription factor activating compounds and targets thereof
JP2012503618A (en) * 2008-09-25 2012-02-09 エフ．ホフマン−ラ ロシュ アーゲー 3-amino-indazole or 3-amino-4,5,6,7-tetrahydroindazole derivatives
WO2014111356A1 (en) 2013-01-17 2014-07-24 F. Hoffmann-La Roche Ag Oxytocin receptor agonists for the treatment of cns diseases

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0192951A2 (en) * 1985-02-02 1986-09-03 Bayer Ag 5-Sulfonamido-1-aryl pyrazoles
EP0192951A3 (en) * 1985-02-02 1986-09-10 Bayer Ag 5-sulfonamido-1-aryl pyrazoles
AU576659B2 (en) * 1985-02-02 1988-09-01 Bayer Aktiengesellschaft 5-sulphonamido-1-aryl-pyrazoles
US4806144A (en) * 1985-02-02 1989-02-21 Bayer Aktiengesellschaft 5-Sulphonamido-1-aryl-pyrazoles
EP1698335A1 (en) * 2003-12-26 2006-09-06 Ono Pharmaceutical Co., Ltd. Preventive and/or therapeutic agent for disease in which mitochondrial benzodiazepine receptor participates
EP1698335A4 (en) * 2003-12-26 2007-08-01 Ono Pharmaceutical Co Preventive and/or therapeutic agent for disease in which mitochondrial benzodiazepine receptor participates
US9718784B2 (en) 2008-05-15 2017-08-01 Duke University Substituted pyrazoles as heat shock transcription factor activators
US9315449B2 (en) * 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
US20110112073A1 (en) * 2008-05-15 2011-05-12 Duke University Compositions and methods relating to heat shock transcription factor activating compounds and targets thereof
JP2012503618A (en) * 2008-09-25 2012-02-09 エフ．ホフマン−ラ ロシュ アーゲー 3-amino-indazole or 3-amino-4,5,6,7-tetrahydroindazole derivatives
US9447058B2 (en) 2010-11-12 2016-09-20 Duke University Substituted 1,3-thiazoles as heat shock transcription factor 1 activators
US9717709B2 (en) 2010-11-12 2017-08-01 Duke University Substituted pyrazoles as heat shock transcription factor activators
WO2014111356A1 (en) 2013-01-17 2014-07-24 F. Hoffmann-La Roche Ag Oxytocin receptor agonists for the treatment of cns diseases
US20150322058A1 (en) * 2013-01-17 2015-11-12 Hoffmann-La Roche Inc. Oxytocin receptor agonists for the treatment of CNS diseases
US9751870B2 (en) * 2013-01-17 2017-09-05 Hoffman-La Roche Inc. Oxytocin receptor agonists for the treatment of CNS diseases
RU2664705C2 (en) * 2013-01-17 2018-08-21 Ф. Хоффманн-Ля Рош Аг Oxytocine receptor agonists for the central nervous system diseases treatment

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