ES318460A1 - Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES318460A1 ES318460A1 ES0318460A ES318460A ES318460A1 ES 318460 A1 ES318460 A1 ES 318460A1 ES 0318460 A ES0318460 A ES 0318460A ES 318460 A ES318460 A ES 318460A ES 318460 A1 ES318460 A1 ES 318460A1
- Authority
- ES
- Spain
- Prior art keywords
- signifies
- radical
- translation
- ocoam
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
Abstract
"Procedure for the production of podophyllotoxin derivatives" of general formula I, **(See formula)** wherein one of the two substituents R1 signifies the radical -OCOAm and the other substituent signifies a hydrogen atom and R2 signifies a methoxy radical or the radical -OCOAm, or the two substituents R1 signifies hydrogen and R2 signifies the radical -OCOAm, Am denoting the amino radical, a (C1-C4) monoalkyl-, phenyl or benzyl-amino radical characterized in that a compound of general formula II is reacted **(See formula)** wherein R'1 signifies hydroxyl and the other substituent R'1 signifies a hydrogen atom and R'2 signifies a methoxy or hydroxyl radical or the two substituents R'1 signifies hydrogen atoms and R'2 signifies hydroxyl, with a derived from the carbamic acid of general formula III, X - CO - Am III in which Am has the meaning indicated above and X means a chlorine or bromine atom or a lower alkoxy radical, in an inert anhydrous solvent, and when X means a chlorine or bromine atom, in the presence of a tertiary base at a temperature from -20ºC to 60ºC. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1050964A CH454169A (en) | 1964-08-12 | 1964-08-12 | Process for the preparation of new podophyllotoxin derivatives |
| CH788865 | 1965-06-04 | ||
| CH819965 | 1965-06-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES318460A1 true ES318460A1 (en) | 1966-04-01 |
Family
ID=27175878
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0316314A Expired ES316314A1 (en) | 1964-08-12 | 1965-08-10 | Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) |
| ES0318461A Expired ES318461A1 (en) | 1964-08-12 | 1965-10-14 | Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) |
| ES0318460A Expired ES318460A1 (en) | 1964-08-12 | 1965-10-14 | Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0316314A Expired ES316314A1 (en) | 1964-08-12 | 1965-08-10 | Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) |
| ES0318461A Expired ES318461A1 (en) | 1964-08-12 | 1965-10-14 | Procedure for the production of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) |
Country Status (14)
| Country | Link |
|---|---|
| AT (1) | AT268540B (en) |
| BE (1) | BE668122A (en) |
| BR (1) | BR6572038D0 (en) |
| CH (1) | CH454169A (en) |
| DE (1) | DE1518324A1 (en) |
| DK (3) | DK111362B (en) |
| ES (3) | ES316314A1 (en) |
| FI (1) | FI44410B (en) |
| FR (2) | FR1468767A (en) |
| GB (1) | GB1114123A (en) |
| IL (1) | IL24135A (en) |
| NL (1) | NL6510414A (en) |
| NO (1) | NO119416B (en) |
| OA (1) | OA01792A (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4024148B2 (en) * | 2000-11-20 | 2007-12-19 | ソンベ キム | Novel 4'-demethyl-4'-O-substituted-1-deoxypodophyllotoxin derivative and geometric isomer thereof, process for producing the same, and anticancer agent composition comprising the same |
| US7342114B2 (en) * | 2003-07-01 | 2008-03-11 | California Pacific Medical Center | Podophyllotoxin derivatives |
| JP6550538B2 (en) | 2015-10-27 | 2019-07-24 | カリフォルニア パシフィック メディカル センター | Podophyllotoxin derivatives and their use |
| US10087194B2 (en) | 2015-10-27 | 2018-10-02 | California Pacific Medical Center | Podophyllotoxin derivatives and their use |
-
1964
- 1964-08-12 CH CH1050964A patent/CH454169A/en unknown
-
1965
- 1965-07-30 GB GB32730/65A patent/GB1114123A/en not_active Expired
- 1965-08-06 DE DE19651518324 patent/DE1518324A1/en active Pending
- 1965-08-10 FR FR27816A patent/FR1468767A/en not_active Expired
- 1965-08-10 NL NL6510414A patent/NL6510414A/xx unknown
- 1965-08-10 ES ES0316314A patent/ES316314A1/en not_active Expired
- 1965-08-10 BE BE668122D patent/BE668122A/xx unknown
- 1965-08-11 IL IL24135A patent/IL24135A/en unknown
- 1965-08-11 OA OA52144A patent/OA01792A/en unknown
- 1965-08-11 FI FI1939/65A patent/FI44410B/fi active
- 1965-08-11 AT AT823567A patent/AT268540B/en active
- 1965-08-11 BR BR172038/65A patent/BR6572038D0/en unknown
- 1965-10-14 ES ES0318461A patent/ES318461A1/en not_active Expired
- 1965-10-14 ES ES0318460A patent/ES318460A1/en not_active Expired
- 1965-11-09 FR FR37802A patent/FR4867M/fr not_active Expired
-
1966
- 1966-09-21 DK DK490666AA patent/DK111362B/en unknown
- 1966-09-21 DK DK490566AA patent/DK113368B/en unknown
- 1966-11-04 NO NO165461A patent/NO119416B/no unknown
-
1968
- 1968-03-14 DK DK108468AA patent/DK116294B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CH454169A (en) | 1968-04-15 |
| ES316314A1 (en) | 1966-04-16 |
| NO119416B (en) | 1970-05-19 |
| GB1114123A (en) | 1968-05-15 |
| AT268540B (en) | 1969-02-10 |
| BR6572038D0 (en) | 1973-08-16 |
| OA01792A (en) | 1970-01-14 |
| DK116294B (en) | 1969-12-29 |
| DK113368B (en) | 1969-03-17 |
| NL6510414A (en) | 1966-02-14 |
| FR1468767A (en) | 1967-02-10 |
| FR4867M (en) | 1967-02-27 |
| BE668122A (en) | 1966-02-10 |
| FI44410B (en) | 1971-08-02 |
| DE1518324A1 (en) | 1969-08-21 |
| DK111362B (en) | 1968-08-05 |
| ES318461A1 (en) | 1966-06-01 |
| IL24135A (en) | 1969-02-27 |
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