ES319647A1 - Procedure for the preparation of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES319647A1
ES319647A1 ES0319647A ES319647A ES319647A1 ES 319647 A1 ES319647 A1 ES 319647A1 ES 0319647 A ES0319647 A ES 0319647A ES 319647 A ES319647 A ES 319647A ES 319647 A1 ES319647 A1 ES 319647A1
Authority
ES
Spain
Prior art keywords
substituents
signifies
translation
derivatives
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0319647A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES319647A1 publication Critical patent/ES319647A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"Procedure for the preparation of derivatives of podophyllotoxin" of general formula I ** (See formula) ** where either one of the two substituents R1 "signifies the residue O-CO-NH-CO-NH2 and the other hydrogen and R" 2 signifies a methoxy radical or likewise the residue O-CO-NH-CO-NH2 or both substituents R''1 signify hydrogen and R''2 the rest O-CO-NH-CO-NH2 characterized in that the compounds of general formula ** (See formula) ** where one of the two substituents R'1 signifies hydroxyl and the other hydrogen and R'2 signifies a methoxy or hydroxyl radical or both substituents R'1 signify hydrogen and R'2 hydroxyl, are reacted with cyanic acid in an anhydrous organic solvent , inert under the reaction conditions, at a temperature between -10º to + 60º, preferably at room temperature or slightly higher temperature. (Machine-translation by Google Translate, not legally binding)
ES0319647A 1964-11-18 1965-11-16 Procedure for the preparation of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding) Expired ES319647A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1485164 1964-11-18

Publications (1)

Publication Number Publication Date
ES319647A1 true ES319647A1 (en) 1966-08-01

Family

ID=4404313

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0319647A Expired ES319647A1 (en) 1964-11-18 1965-11-16 Procedure for the preparation of derivatives of podofilotoxina. (Machine-translation by Google Translate, not legally binding)

Country Status (2)

Country Link
ES (1) ES319647A1 (en)
FR (2) FR1455540A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2810321B1 (en) * 2000-06-20 2002-07-26 Adir NOVEL PODOPHYLLOTOXIN CARBAMATE AND THIOCARBAMATE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
FR1455540A (en) 1966-10-14
FR5224M (en) 1967-07-10

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