GB850351A - Preparation of streptomycin - Google Patents
Preparation of streptomycinInfo
- Publication number
- GB850351A GB850351A GB5689/58A GB568958A GB850351A GB 850351 A GB850351 A GB 850351A GB 5689/58 A GB5689/58 A GB 5689/58A GB 568958 A GB568958 A GB 568958A GB 850351 A GB850351 A GB 850351A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkali metal
- metal salt
- streptomycin
- cultivation
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Streptomycin is produced in enhanced yields by fermenting a nutrient medium at pH5 to 8 with a streptomycin-producing micro-organism, e.g. Streptomyces griseus in the presence of an alkali metal salt of p-(2-hydroxy-1-naphthylazo) benzene sulphonic acid, an alkali metal salt of diphenyldiazo-bis-a -naphthylaminesulphonic acid or an alkali metal salt of p-dimethyl aminophenylazobenzene sulphonic acid. The medium contains (a) carbohydrate such as sucrose, dextrose or starch (b) nitrogen source such as ammonium salts, corn steep liquor, casein, soybean meal and peptones (c) mineral salts such as potassium dihydrogen phosphate, zinc sulphate, magensium sulphate and calcium carbonate. The pH is preferably 6 to 7,5, the temperature of cultivation 24 to 30 DEG C. and the duration 1 to 5 days. Cultivation may be surface or submerged, which is preferred. The dyestuff is added before or after inoculation with the Streptomyces griseus, in which case it is added within 24 hours of initiation of the fermentation. It is used in quantities of 0,20 to 2,5 g. per litre of the medium. Alkali metal dye salts such as potassium and lithium may be used but the sodium salt is preferred.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US850351XA | 1957-03-11 | 1957-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB850351A true GB850351A (en) | 1960-10-05 |
Family
ID=22189047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5689/58A Expired GB850351A (en) | 1957-03-11 | 1958-02-21 | Preparation of streptomycin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB850351A (en) |
-
1958
- 1958-02-21 GB GB5689/58A patent/GB850351A/en not_active Expired
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