GB842659A - Steroid compounds and their preparation - Google Patents

Steroid compounds and their preparation

Info

Publication number
GB842659A
GB842659A GB2630957A GB2630957A GB842659A GB 842659 A GB842659 A GB 842659A GB 2630957 A GB2630957 A GB 2630957A GB 2630957 A GB2630957 A GB 2630957A GB 842659 A GB842659 A GB 842659A
Authority
GB
United Kingdom
Prior art keywords
ynyl
preparation
dien
alkyl
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2630957A
Inventor
Bernard Ellis
Vladimir Petrow
Martin Stansfield
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BDH Chemicals Ltd
Original Assignee
BDH Chemicals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BDH Chemicals Ltd filed Critical BDH Chemicals Ltd
Priority to GB2630957A priority Critical patent/GB842659A/en
Publication of GB842659A publication Critical patent/GB842659A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises steroids of the general formula: <FORM:0842659/IV(b)/1> (wherein R is alkyl of at most 5 carbon atoms) and their preparation by reacting a steroid of the general formula <FORM:0842659/IV(b)/2> (wherein R1 is alkyl of at most 8 carbon atoms) with the appropriate alkynyl magnesium halide to give the corresponding 3-alkoxy-17 a -alkynyloestra-2:5(10)-dien-17b -ol and then treating this with an acidic reagent such as acetic acid or oxalic acid. The invention also comprises the specific intermediates 3-methoxy-17 a -(prop-1-ynyl)-oestra-2:5(10)-dien-17b -ol and the corresponding but-1-ynyl and pent-1-ynyl compounds. Examples are given.
GB2630957A 1957-08-20 1957-08-20 Steroid compounds and their preparation Expired GB842659A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2630957A GB842659A (en) 1957-08-20 1957-08-20 Steroid compounds and their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2630957A GB842659A (en) 1957-08-20 1957-08-20 Steroid compounds and their preparation

Publications (1)

Publication Number Publication Date
GB842659A true GB842659A (en) 1960-07-27

Family

ID=10241620

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2630957A Expired GB842659A (en) 1957-08-20 1957-08-20 Steroid compounds and their preparation

Country Status (1)

Country Link
GB (1) GB842659A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2007426A1 (en) * 1968-04-10 1970-01-09 Sandoz Sa

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2007426A1 (en) * 1968-04-10 1970-01-09 Sandoz Sa

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