GB936893A - New steroid compounds and processes for the preparation thereof - Google Patents
New steroid compounds and processes for the preparation thereofInfo
- Publication number
- GB936893A GB936893A GB18012/61A GB1801261A GB936893A GB 936893 A GB936893 A GB 936893A GB 18012/61 A GB18012/61 A GB 18012/61A GB 1801261 A GB1801261 A GB 1801261A GB 936893 A GB936893 A GB 936893A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acyloxy
- oestra
- nitrogen
- processes
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises compounds having the formula: <FORM:0936893/IV(a)/1> wherein -OAc represents an acyloxy radical and R and R1, which may be the same or different each represents a hydrogen atom or an alkyl or hydroxy alkyl radical having from 1-6 carbon atoms, or together with the nitrogen atom, constitute a nitrogen or a nitrogen and oxygen containing heterocyclic residue and processes for the preparation thereof (a) by reacting a 3b -methyl-7-keto-8b -(g -keto-butyl)-8a ,9a -epoxy-3a , 4b -[31-acyloxy-(21,11) -cyclopentano]- decahydronaphthalene with an acid addition salt of a primary or secondary amine H.NRR1 or (b) by cyclising by an alkali metal acylate the starting compound in (a) to yield the corresponding 9a ,10a -epoxy-19-nortestosterone ester which is reacted with a primary or secondary amine of general formula H.NRR1 so as to form the corresponding 3-amino-9a -hydroxy-17b -acyloxy-oestra-1,3,5(10)-triene and dehydrating the latter to yield the desired corresponding 3-amino-17b -acyloxy-oestra-1,3,5 (10),9(11)-tetraene. A preferred product is 3-pyrrolidinyl- 17b -benzoyloxy-oestra-1,3,5(10), 9(11)-tetraene. Specification 936,894 is referred to.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR828241A FR1269641A (en) | 1960-05-25 | 1960-05-25 | New process for the preparation of aminosteroids |
FR828240A FR1363863A (en) | 1960-05-25 | 1960-05-25 | Process for the preparation of aminosteroids |
Publications (1)
Publication Number | Publication Date |
---|---|
GB936893A true GB936893A (en) | 1963-09-18 |
Family
ID=26186167
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB18012/61A Expired GB936893A (en) | 1960-05-25 | 1961-05-17 | New steroid compounds and processes for the preparation thereof |
GB12180/63A Expired GB936894A (en) | 1960-05-25 | 1961-05-17 | Novel steroid compounds and processes for the preparation thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB12180/63A Expired GB936894A (en) | 1960-05-25 | 1961-05-17 | Novel steroid compounds and processes for the preparation thereof |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE604204A (en) |
CH (2) | CH404655A (en) |
GB (2) | GB936893A (en) |
NL (1) | NL110320C (en) |
SE (1) | SE305651B (en) |
-
1961
- 1961-05-17 GB GB18012/61A patent/GB936893A/en not_active Expired
- 1961-05-17 GB GB12180/63A patent/GB936894A/en not_active Expired
- 1961-05-18 CH CH581561A patent/CH404655A/en unknown
- 1961-05-18 CH CH1403365A patent/CH490354A/en not_active IP Right Cessation
- 1961-05-25 NL NL265167A patent/NL110320C/xx active
- 1961-05-25 BE BE604204A patent/BE604204A/en unknown
-
1962
- 1962-08-27 SE SE9287/62A patent/SE305651B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CH490354A (en) | 1970-05-15 |
NL110320C (en) | 1964-07-15 |
CH404655A (en) | 1965-12-31 |
GB936894A (en) | 1963-09-18 |
SE305651B (en) | 1968-11-04 |
BE604204A (en) | 1961-11-27 |
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