GB838706A - New thioxanthones - Google Patents
New thioxanthonesInfo
- Publication number
- GB838706A GB838706A GB25435/56A GB2543556A GB838706A GB 838706 A GB838706 A GB 838706A GB 25435/56 A GB25435/56 A GB 25435/56A GB 2543556 A GB2543556 A GB 2543556A GB 838706 A GB838706 A GB 838706A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- lower alkyl
- chloro
- aza
- isobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 1-aza-2-lower alkyl-6 - tertiary - amino - lower alkylamino - 9-methylthioxanthones and acid addition salts thereof wherein the lower alkyl groups contain 5 carbon atoms at the most, and the preparation thereof by replacing the halogen atom in a 1-aza - 2 - lower alkyl - 6 - halo - 9 - methyl-thioxanthone by a tertiary amino-lower alkyl-amino group by known methods for replacements of this type, and if desired any salts obtained are converted into the free bases and any free bases into their acid addition salts. The compounds of the invention may also be prepared by converting a suitable residue in the 6-position e.g. an amino group into a tertiary amino group e.g. by reaction with an ester of a tertiary aminoalkanol and a strong acid. 1 - Aza - 2 : 9 - dimethyl - 6 - chloro - thioxanthone and 1 - aza - 2 - isobutyl - 6 - chloro - 9-methyl-thioxanthone are prepared by reacting 2-chloro - 3 - cyano - 6 - methyl - or 6 - isobutyl-pyridines with sodium 2 - methyl - 5 - chlorothiophenol to form 6 - methyl - and 6 - isobutyl - 3 - cyano - 2 - (51 - chloro - 21 - methylphenyl - thiol) - pyridines, hydrolysing these to the 6 - methyl - or 6 - isobutyl - 3 - carboxy-2 - (51 - chloro - 21 - methyl - phenyl - thiol)-pyridines and subjecting these to ring closure.ALSO:Pharmaceutical preparations suitable for enteral, parenteral or local administration comprise 1-azo-2 lower alkyl-6-tertiary amino-lower alkyl-amino-9-methyl thioxanthones and acid addition salts thereof, wherein the lower alkyl groups contain at the most 5 carbon atoms, in admixture with a pharmaceutical organic or inorganic, solid or liquid carrier. The preparations may be in the form of tablets, dragees, salves, creams, solutions, suspensions or emulsions and may contain auxiliary substances, e.g. preservatives, stabilizing, wetting or emulsifying agents, salts for varying the osmotic pressure and buffer substances. Suitable salts are hydrochloric, acetic, propionic, oxalic, malonic, succinic, malic and benzene or toluene sulphonic acid.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH838706X | 1955-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB838706A true GB838706A (en) | 1960-06-22 |
Family
ID=4540987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB25435/56A Expired GB838706A (en) | 1955-08-19 | 1956-08-20 | New thioxanthones |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB838706A (en) |
-
1956
- 1956-08-20 GB GB25435/56A patent/GB838706A/en not_active Expired
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