GB822696A - Novel nicotinoyl-hydrazine derivatives and a process for the manufacture thereof - Google Patents
Novel nicotinoyl-hydrazine derivatives and a process for the manufacture thereofInfo
- Publication number
- GB822696A GB822696A GB10451/58A GB1045158A GB822696A GB 822696 A GB822696 A GB 822696A GB 10451/58 A GB10451/58 A GB 10451/58A GB 1045158 A GB1045158 A GB 1045158A GB 822696 A GB822696 A GB 822696A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- acid addition
- base
- hydrazine
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:0822696/IV (a)/1> and acid addition salts thereof, wherein R1 stands for a saturated non-aromatic hydrocarbon group containing 2-7 carbon atoms and the broken line denotes that the methyl group is optional, and the preparation thereof by either condensing an acid of the formula <FORM:0822696/IV (a)/2> or a salt thereof with an organic base (in the presence of a carbodiimide) or a reactive derivative thereof with a substituted hydrazine of the formula R1-NH-NH2 or reacting a nicotinic acid hydrazide of the formula <FORM:0822696/IV (a)/3> with a carbonyl compound containing 2-7 carbon atoms, simultaneously or successively hydrogenating the resulting hydrazone and in either case, if desired, transforming the product (if a base) into an acid addition salt or (if an acid addition salt) into the base. It is further disclosed in the Specification that the hydrazone formed in the alternative process above may be reacted with a Grignard reagent and the product hydrolysed to form a hydrazine. N,N1 - Disubstituted - carbodiimides (e.g. N,N1-dicylohexylcarbodiimide) used in the condensation reaction may be prepared by treating an appropriately di-substituted-urea with p-toluenesulphochloride in piperidine.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH822696X | 1957-04-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB822696A true GB822696A (en) | 1959-10-28 |
Family
ID=4539595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB10451/58A Expired GB822696A (en) | 1957-04-09 | 1958-04-01 | Novel nicotinoyl-hydrazine derivatives and a process for the manufacture thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB822696A (en) |
-
1958
- 1958-04-01 GB GB10451/58A patent/GB822696A/en not_active Expired
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