GB814586A - A new therapeutically useful cysteine compound and a process for the production thereof - Google Patents

A new therapeutically useful cysteine compound and a process for the production thereof

Info

Publication number
GB814586A
GB814586A GB31009/57A GB3100957A GB814586A GB 814586 A GB814586 A GB 814586A GB 31009/57 A GB31009/57 A GB 31009/57A GB 3100957 A GB3100957 A GB 3100957A GB 814586 A GB814586 A GB 814586A
Authority
GB
United Kingdom
Prior art keywords
cysteine
sulphate
sulphuric acid
molar ratio
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31009/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordmark Werke GmbH
Original Assignee
Nordmark Werke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordmark Werke GmbH filed Critical Nordmark Werke GmbH
Publication of GB814586A publication Critical patent/GB814586A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises di-cysteine sulphate and its preparation whereby an aqueous solution of cysteine and sulphuric acid with a molar ratio of 2 mols. cysteine: 1 mol. sulphuric acid, or a molar ratio not differing from this molar ratio by more than 0.1 mol. is evaporated in vacuo at a temperature from 0-40 DEG C. until crystallization begins, the resulting crystals shaken at room temperature with a monohydric alcohol containing 2 or 3 carbon atoms, the residue of di-cysteine sulphate separated from the alcohol and the di-cysteine sulphate dried in vacuo at a temperature 0-30 DEG C. An example describes the preparation of di-cysteine sulphate by evaporation of a solution of cysteine and sulphuric acid (obtained by the electrolysis of cystine in the presence of sulphuric acid), the residue being washed with isopropanol.ALSO:A solution for injection is prepared by dissolving dicysteine sulphate and cysteine in water and buffering to pH 3.0-4.0. Alternatively dicysteine sulphate may be pressed to form tablets after granulating with spermaceti and, as tableting additives, silica, talcum and magnesium stearate.
GB31009/57A 1957-07-20 1957-10-03 A new therapeutically useful cysteine compound and a process for the production thereof Expired GB814586A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE814586X 1957-07-20

Publications (1)

Publication Number Publication Date
GB814586A true GB814586A (en) 1959-06-10

Family

ID=6734571

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31009/57A Expired GB814586A (en) 1957-07-20 1957-10-03 A new therapeutically useful cysteine compound and a process for the production thereof

Country Status (1)

Country Link
GB (1) GB814586A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045415A1 (en) * 1980-07-31 1982-02-10 Tanabe Seiyaku Co., Ltd. Di-L-cysteine L-malate and process for the production thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0045415A1 (en) * 1980-07-31 1982-02-10 Tanabe Seiyaku Co., Ltd. Di-L-cysteine L-malate and process for the production thereof

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