GB809105A - Processes for solubilising amorphous nystatin and compositions containing the same - Google Patents
Processes for solubilising amorphous nystatin and compositions containing the sameInfo
- Publication number
- GB809105A GB809105A GB18431/57A GB1843157A GB809105A GB 809105 A GB809105 A GB 809105A GB 18431/57 A GB18431/57 A GB 18431/57A GB 1843157 A GB1843157 A GB 1843157A GB 809105 A GB809105 A GB 809105A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nystatin
- surfactant
- sodium
- specifications
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
A morphone or non-crystalline nystatin (fungicidin) is rendered water soluble by the incorporation in the composition of an anionic surfactant. Sodium lauryl sulphate is the preferred surfactant but others such as the aryloxy polyalkylene ether sulphonates, e.g. sodium p-ter-octylphenoxy ethoxyethyl sulphonate, or sodium N-lauroyl sarcosinate may be used. The ratio of nystatin to the anionic surfactant may vary between 1 : 1.5 and 1 : 5 parts by weight. In the preferred process for producing the solubilized nystatin, non-crystalline nystatin is admixed with the surfactant, water is added and the pH of the solution adjusted to within the range 6-8, the solution is then filtered and freeze dried. Specifications 714,189, 796,512 and U.S.A. Specifications 2,115,192 and 2,628,187 are referred to.ALSO:Amorphous or non-crystalline nystatin (fungicidin) is rendered water-soluble by the incorporation in the composition of an anionic surfactant. Sodium lauryl sulphate is the preferred surfactant but others such as the aryloxy polyalkylene ether sulphonates, e.g. sodium p-teroctylphenoxyethoxyethyl sulphonate, or sodium N-lauroyl sarcosinate may be used. The ratio of nystatin to the anionic surfactant may vary between 1 : 0.5 and 1 : 5 parts by weight. The compositions may be incorporated in tablets, vaginal suppositories or in ointments, especially ointments having a base formed of polyethylene and a mineral oil. In the preferred process for producing the solubilized nystatin compositions, non-crystalline nystatin is admixed with the surfactant, water is added and the pH of the solution adjusted to within the range 6-8, the solution is then filtered and freeze dried. Specifications 714,189, 796,512, [both in Group IV (b)], and U.S.A. Specifications 2,115,192 and 2,628,187 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US809105XA | 1956-06-08 | 1956-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB809105A true GB809105A (en) | 1959-02-18 |
Family
ID=22160431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB18431/57A Expired GB809105A (en) | 1956-06-08 | 1957-06-11 | Processes for solubilising amorphous nystatin and compositions containing the same |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB809105A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1296143B (en) * | 1964-02-15 | 1969-05-29 | Le Nii Antibiotika | Process for the production of water-soluble sodium salts of the polyene antibiotics nystatin and levorin |
US4185092A (en) * | 1977-10-03 | 1980-01-22 | E. R. Squibb & Sons, Inc. | Purification of nystatin in an aqueous system |
US5567685A (en) * | 1994-08-16 | 1996-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Water-Soluble polyene conjugate |
US6011008A (en) * | 1997-01-08 | 2000-01-04 | Yissum Research Developement Company Of The Hebrew University Of Jerusalem | Conjugates of biologically active substances |
WO2001068102A2 (en) * | 2000-03-10 | 2001-09-20 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
WO2020160443A1 (en) | 2019-01-31 | 2020-08-06 | Sigma-Aldrich Co. Llc | Antifungal agents with improved water solubility |
-
1957
- 1957-06-11 GB GB18431/57A patent/GB809105A/en not_active Expired
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1296143B (en) * | 1964-02-15 | 1969-05-29 | Le Nii Antibiotika | Process for the production of water-soluble sodium salts of the polyene antibiotics nystatin and levorin |
US4185092A (en) * | 1977-10-03 | 1980-01-22 | E. R. Squibb & Sons, Inc. | Purification of nystatin in an aqueous system |
US5567685A (en) * | 1994-08-16 | 1996-10-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Water-Soluble polyene conjugate |
US6011008A (en) * | 1997-01-08 | 2000-01-04 | Yissum Research Developement Company Of The Hebrew University Of Jerusalem | Conjugates of biologically active substances |
WO2001068102A2 (en) * | 2000-03-10 | 2001-09-20 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
WO2001068102A3 (en) * | 2000-03-10 | 2002-04-04 | Wisconsin Alumni Res Found | Nystatin formulation having reduced toxicity |
US6413537B1 (en) | 2000-03-10 | 2002-07-02 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
WO2020160443A1 (en) | 2019-01-31 | 2020-08-06 | Sigma-Aldrich Co. Llc | Antifungal agents with improved water solubility |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1458837A (en) | Fabric conditioning compositions | |
FR2186530B1 (en) | ||
GB809105A (en) | Processes for solubilising amorphous nystatin and compositions containing the same | |
DE3170983D1 (en) | Chemical blowing agent composition, its composition and use | |
SE7710021L (en) | PROCEDURE FOR THE PREPARATION OF ETRAR | |
ES8300850A1 (en) | Aqueous, soap-based liquid detergent composition. | |
GB791415A (en) | Improvements in or relating to detergent compositions | |
GB893540A (en) | Polyethylene diluted polypropylene | |
GB973952A (en) | New water soluble mixed cellulose allyl ethers and a process for their manufacture | |
NL83998C (en) | ||
ES399906A1 (en) | Process for the production of dyestuff preparations | |
ES380767A1 (en) | Method of preparing morpholino cyano-acrylamides | |
GB796633A (en) | Improvements in or relating to anti-freeze mixtures | |
RO70855B (en) | Process for preparing pharmacologically active sulphoxides | |
GB498743A (en) | Improved product for treating water for toilet purposes | |
ES454457A1 (en) | Aqueous shampoo compositions | |
US3069359A (en) | Germicidal detergent composition | |
GB994353A (en) | Improvements in detergent compositions | |
GB892015A (en) | Improvements in the properties of hydraulic cements and a process of their manufacture | |
GB573589A (en) | Improvements in or relating to the manufacture of alginic materials | |
GB833201A (en) | Detergent compositions | |
GB688164A (en) | Improvements in dentrifrices | |
GB1511835A (en) | Process for forming a proteinaceous product | |
ES8106750A1 (en) | Process for the preparation of concentrated solutions of metal complex dyestuffs free from sulfonic groups. | |
GB1518807A (en) | Light-duty liquid dtergent compositions having enhanced skin mildnes properties |