GB809105A - Processes for solubilising amorphous nystatin and compositions containing the same - Google Patents

Processes for solubilising amorphous nystatin and compositions containing the same

Info

Publication number
GB809105A
GB809105A GB1843157A GB1843157A GB809105A GB 809105 A GB809105 A GB 809105A GB 1843157 A GB1843157 A GB 1843157A GB 1843157 A GB1843157 A GB 1843157A GB 809105 A GB809105 A GB 809105A
Authority
GB
United Kingdom
Prior art keywords
nystatin
surfactant
sodium
specifications
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1843157A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olin Corp
Original Assignee
Olin Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US809105XA priority Critical
Application filed by Olin Corp filed Critical Olin Corp
Publication of GB809105A publication Critical patent/GB809105A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions

Abstract

A morphone or non-crystalline nystatin (fungicidin) is rendered water soluble by the incorporation in the composition of an anionic surfactant. Sodium lauryl sulphate is the preferred surfactant but others such as the aryloxy polyalkylene ether sulphonates, e.g. sodium p-ter-octylphenoxy ethoxyethyl sulphonate, or sodium N-lauroyl sarcosinate may be used. The ratio of nystatin to the anionic surfactant may vary between 1 : 1.5 and 1 : 5 parts by weight. In the preferred process for producing the solubilized nystatin, non-crystalline nystatin is admixed with the surfactant, water is added and the pH of the solution adjusted to within the range 6-8, the solution is then filtered and freeze dried. Specifications 714,189, 796,512 and U.S.A. Specifications 2,115,192 and 2,628,187 are referred to.ALSO:Amorphous or non-crystalline nystatin (fungicidin) is rendered water-soluble by the incorporation in the composition of an anionic surfactant. Sodium lauryl sulphate is the preferred surfactant but others such as the aryloxy polyalkylene ether sulphonates, e.g. sodium p-teroctylphenoxyethoxyethyl sulphonate, or sodium N-lauroyl sarcosinate may be used. The ratio of nystatin to the anionic surfactant may vary between 1 : 0.5 and 1 : 5 parts by weight. The compositions may be incorporated in tablets, vaginal suppositories or in ointments, especially ointments having a base formed of polyethylene and a mineral oil. In the preferred process for producing the solubilized nystatin compositions, non-crystalline nystatin is admixed with the surfactant, water is added and the pH of the solution adjusted to within the range 6-8, the solution is then filtered and freeze dried. Specifications 714,189, 796,512, [both in Group IV (b)], and U.S.A. Specifications 2,115,192 and 2,628,187 are referred to.
GB1843157A 1956-06-08 1957-06-11 Processes for solubilising amorphous nystatin and compositions containing the same Expired GB809105A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US809105XA true 1956-06-08 1956-06-08

Publications (1)

Publication Number Publication Date
GB809105A true GB809105A (en) 1959-02-18

Family

ID=22160431

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1843157A Expired GB809105A (en) 1956-06-08 1957-06-11 Processes for solubilising amorphous nystatin and compositions containing the same

Country Status (1)

Country Link
GB (1) GB809105A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1296143B (en) * 1964-02-15 1969-05-29 Le Nii Antibiotika Process for the production of water-soluble sodium salts of the polyene antibiotics nystatin and levorin
US4185092A (en) * 1977-10-03 1980-01-22 E. R. Squibb & Sons, Inc. Purification of nystatin in an aqueous system
US5567685A (en) * 1994-08-16 1996-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Water-Soluble polyene conjugate
US6011008A (en) * 1997-01-08 2000-01-04 Yissum Research Developement Company Of The Hebrew University Of Jerusalem Conjugates of biologically active substances
WO2001068102A2 (en) * 2000-03-10 2001-09-20 Wisconsin Alumni Research Foundation Nystatin formulation having reduced toxicity
WO2020160443A1 (en) 2019-01-31 2020-08-06 Sigma-Aldrich Co. Llc Antifungal agents with improved water solubility

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1296143B (en) * 1964-02-15 1969-05-29 Le Nii Antibiotika Process for the production of water-soluble sodium salts of the polyene antibiotics nystatin and levorin
US4185092A (en) * 1977-10-03 1980-01-22 E. R. Squibb & Sons, Inc. Purification of nystatin in an aqueous system
US5567685A (en) * 1994-08-16 1996-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Water-Soluble polyene conjugate
US6011008A (en) * 1997-01-08 2000-01-04 Yissum Research Developement Company Of The Hebrew University Of Jerusalem Conjugates of biologically active substances
WO2001068102A2 (en) * 2000-03-10 2001-09-20 Wisconsin Alumni Research Foundation Nystatin formulation having reduced toxicity
WO2001068102A3 (en) * 2000-03-10 2002-04-04 Wisconsin Alumni Res Found Nystatin formulation having reduced toxicity
US6413537B1 (en) 2000-03-10 2002-07-02 Wisconsin Alumni Research Foundation Nystatin formulation having reduced toxicity
WO2020160443A1 (en) 2019-01-31 2020-08-06 Sigma-Aldrich Co. Llc Antifungal agents with improved water solubility

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