GB791744A - Preparation of 2, 6-dimethylpiperazine - Google Patents
Preparation of 2, 6-dimethylpiperazineInfo
- Publication number
- GB791744A GB791744A GB2151/56A GB215156A GB791744A GB 791744 A GB791744 A GB 791744A GB 2151/56 A GB2151/56 A GB 2151/56A GB 215156 A GB215156 A GB 215156A GB 791744 A GB791744 A GB 791744A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dimethylpiperazine
- catalyst
- reaction
- carried out
- copper
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/023—Preparation; Separation; Stabilisation; Use of additives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Abstract
2 : 6-Dimethylpiperazine is made by contacting diisopropanolamine of the formula: <FORM:0791744/IV (b)/1> and ammonia with a metallic hydrogenation/dehydrogenation catalyst. The reaction is suitably carried out at 125 DEG to 250 DEG C., preferably at 175 DEG to 225 DEG C. The reaction may be carried out in the vapour phase or at superatmospheric pressure in the liquid phase. The catalyst may for example be platinum, palladium, cobalt, iron, copper, copper chromite or zinc chromite, or preferably alloy skeleton nickel catalyst such as Raney nickel. In Examples (1) and (2) diisopropylamine is heated with aqueous ammonia in an autoclave in the presence of Raney nickel to give 2 : 6-dimethylpiperazine.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US791744XA | 1955-01-27 | 1955-01-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB791744A true GB791744A (en) | 1958-03-12 |
Family
ID=22148891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2151/56A Expired GB791744A (en) | 1955-01-27 | 1956-01-23 | Preparation of 2, 6-dimethylpiperazine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB791744A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3151112A (en) * | 1956-05-21 | 1964-09-29 | Jefferson Chem Co Inc | Process for the preparation of morpholines |
| US3154544A (en) * | 1956-05-02 | 1964-10-27 | Wyandotte Chemicals Corp | Substituted morpholines |
| US6365741B2 (en) * | 1999-02-24 | 2002-04-02 | Bayer Aktiengesellschaft | Process for preparing Cis-2,6-dimethylpiperazine |
-
1956
- 1956-01-23 GB GB2151/56A patent/GB791744A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3154544A (en) * | 1956-05-02 | 1964-10-27 | Wyandotte Chemicals Corp | Substituted morpholines |
| US3151112A (en) * | 1956-05-21 | 1964-09-29 | Jefferson Chem Co Inc | Process for the preparation of morpholines |
| US6365741B2 (en) * | 1999-02-24 | 2002-04-02 | Bayer Aktiengesellschaft | Process for preparing Cis-2,6-dimethylpiperazine |
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