GB772192A - Improvements in or relating to the production of thyrotropin preparations - Google Patents

Improvements in or relating to the production of thyrotropin preparations

Info

Publication number
GB772192A
GB772192A GB28546/54A GB2854654A GB772192A GB 772192 A GB772192 A GB 772192A GB 28546/54 A GB28546/54 A GB 28546/54A GB 2854654 A GB2854654 A GB 2854654A GB 772192 A GB772192 A GB 772192A
Authority
GB
United Kingdom
Prior art keywords
thyrotropin
mono
per cent
addition
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28546/54A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Armour and Co
Original Assignee
Armour and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Armour and Co filed Critical Armour and Co
Publication of GB772192A publication Critical patent/GB772192A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Thyrotropin is selectively precipitated from an aqueous solution of thyrotropin and non-thyroid stimulating proteins from pituitary material by the addition of a mono-hydroxy alkane containing less than 4 carbon atoms until the concentration of the said mono-hydroxy alkane is from 5 to 35 per cent by volume. Ethanol is the preferred precipitating agent. The fractionation is carried out at low temperatures preferably between -5 DEG C. and +5 DEG C. The process is particularly adapted for separating thyrotropin from gonadotropin. The thyrotropin precipitate is purified by a process which involves forming a solution at pH 4, removing precipitates formed on the addition of acetone, until finally the thyrotropin is precipitated at an 80 per cent acetone concentration. A detailed procedure of extraction and purification is described in the examples.
GB28546/54A 1953-10-12 1954-10-04 Improvements in or relating to the production of thyrotropin preparations Expired GB772192A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US772192XA 1953-10-12 1953-10-12

Publications (1)

Publication Number Publication Date
GB772192A true GB772192A (en) 1957-04-10

Family

ID=22136757

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28546/54A Expired GB772192A (en) 1953-10-12 1954-10-04 Improvements in or relating to the production of thyrotropin preparations

Country Status (1)

Country Link
GB (1) GB772192A (en)

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