GB771338A - Novel antibiotically active products - Google Patents

Abstract

The pantothenic acid salts of streptomycin, dihydrostreptomycin, neomycin and viomycin are produced by reacting a salt of the basic antibiotic with pantothenic acid or a functional derivative of this acid which in the living organism can be transformed into pantothenic acid or which can liberate this acid, e.g. pantothenal, pantothenic acid lactone, pantothenol, pantothenic acid amides and esters of pantothenic acid in which the hydroxyl group of pantothenic acid is esterified with an acid such as phosphoric acid, acetic acid or phthalic acid, or the carboxyl group of pantothenic acid is esterified with an alcohol such as a monohydric alcohol containing 1 to 6 carbon atoms or inositol. It is preferred to react a salt of the antibiotic, e.g. sulphate, with an alkali metal or alkaline earth metal salt of pantothenic acid. Examples describe the preparation of (a) streptomycin pantothenate, (b) dihydrostreptomycin pantothenate, (c) mixed salts of (a) and (b), (d) neomycin pantothenate and (e) viomycin pantothenate. The salts may be incorporated in medicines (see Group VI). Specification 687,500 is referred to.ALSO:Medicines comprise a therapeutically active product wherein streptomycin, dihydro-streptomycin neomycin, niomycin or a salt thereof is reacted to form a chemical compound (see Group IV(b)) or is worked up to form a medicinal mixture, with pantothenic acid or a functional derivative of this acid which in the living organism can be transformed into pantothenic acid or which can liberate this acid e.g. pantothenal, pantothenic acid lactone, pantothenol, pantothenic acid amides and esters of pantothenic acid in which the hydroxyl group of pantothenic acid is esterified with an acid such as phosphoric acetic or phthalic, or the carboxyl group of the pantothenic acid is esterified with an alcohol such as a monohydric alcohol containing 1 to 6 carbon atoms or inisitol. The presence of the pantothenic acid compound eliminates the undesirable secondary effects produced by the administration of the said antibiotics. The preparations may be administered in the form of solutions, powders and ointments and other active ingredients e.g. penicillin, procaine penicillin or oxycaine penicillin may be present. Specification 687,500 [Group IV(b)] is referred to.