GB769130A - Process for the manufacture of substituted ureas - Google Patents
Process for the manufacture of substituted ureasInfo
- Publication number
- GB769130A GB769130A GB6914/55A GB691455A GB769130A GB 769130 A GB769130 A GB 769130A GB 6914/55 A GB6914/55 A GB 6914/55A GB 691455 A GB691455 A GB 691455A GB 769130 A GB769130 A GB 769130A
- Authority
- GB
- United Kingdom
- Prior art keywords
- urea
- phenyl
- aniline
- dimethyl
- excess
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Ureas of the formula R1-NH-CO-NR2R3, where R1 is a cyclic hydrocarbon residue (which may be halogen substituted) and R2 and R3 are aliphatic hydrocarbon radicals or one may be hydrogen, are prepared by maintaining a mixture of a symmetrical urea R1-NH-CO-NH-R1 and an amine HNR2R3 at an elevated temperature until reaction is complete. In the examples: (1) 1:3-diphenylurea (from urea and aniline) is heated with mono- and di-methylamine to give 1-phenyl-3-methyl-urea and 1-phenyl - 3:3 - dimethyl - urea respectively; (2) 1 - (p - chlorophenyl) - 3:3 - dimethyl - urea and 1-(o-tolyl)-3-methyl-urea are obtained similarly from the appropriate reactants. Suitable apparatus is illustrated. R1 may also be diphenylyl, aralkyl-phenyl, cyclohexyl or alkylcyclohexyl, and R2 and R3 may be other alkyl radicals, preferably having no more than 6 carbon atoms. The reaction may be carried out at a temperature above 150 DEG C., preferably 300-500 DEG C., the pressure being usually atmospheric. In the two-stage process of Example 1 an excess of aniline is used to act as solvent for the second stage; benzene may, however, be employed instead. The aliphatic amine is preferably used in excess of the theoretical.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US769130XA | 1954-03-16 | 1954-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB769130A true GB769130A (en) | 1957-02-27 |
Family
ID=22134940
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6914/55A Expired GB769130A (en) | 1954-03-16 | 1955-03-09 | Process for the manufacture of substituted ureas |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB769130A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102030684A (en) * | 2009-09-25 | 2011-04-27 | 李其奎 | Clean production method for symmetrical N,N'-dialkylurea |
-
1955
- 1955-03-09 GB GB6914/55A patent/GB769130A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102030684A (en) * | 2009-09-25 | 2011-04-27 | 李其奎 | Clean production method for symmetrical N,N'-dialkylurea |
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