GB722467A - Improvements in and relating to the manufacture of ª‰-n-morpholinoethylmorphine - Google Patents
Improvements in and relating to the manufacture of ª‰-n-morpholinoethylmorphineInfo
- Publication number
- GB722467A GB722467A GB2075352A GB2075352A GB722467A GB 722467 A GB722467 A GB 722467A GB 2075352 A GB2075352 A GB 2075352A GB 2075352 A GB2075352 A GB 2075352A GB 722467 A GB722467 A GB 722467A
- Authority
- GB
- United Kingdom
- Prior art keywords
- morphinate
- bromoethylmorpholine
- alcoholic
- atmosphere
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
b - N - Morpholinoethylmorphine is prepared by reacting an N-b -halogenoethylmorpholine with an alkali metal morphinate in solution in a substantially anhydrous solvent and preferably in an atmosphere of an inert gas, e.g. nitrogen. In examples: (1) alcoholic morphine is treated with sodium ethoxide, and the sodium morphinate refluxed with alcoholic N-b -chloroethylmorpholine hydrochloride (previously neutralized with sodium ethoxide); (2) as in (1) using an atmosphere of nitrogen; (3) as in (2) but using N-b -bromoethylmorpholine hydrobromide as halogen component; (4), (5) and (8) employ methanol, iso-propanol and dioxane respectively as the solvent; (6) and (7) toluene and benzene respectively are added to the reaction mixture of example (2) as the ethanol distils to maintain a constant volume of reactants. N - b - Bromoethylmorpholine hydrobromide used as a starting material in example (3) is prepared from N-b -hydroxyethylmorpholine and phosphorus tribromide. Specification 680,952 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2075352A GB722467A (en) | 1952-08-18 | 1952-08-18 | Improvements in and relating to the manufacture of ª‰-n-morpholinoethylmorphine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2075352A GB722467A (en) | 1952-08-18 | 1952-08-18 | Improvements in and relating to the manufacture of ª‰-n-morpholinoethylmorphine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB722467A true GB722467A (en) | 1955-01-26 |
Family
ID=10151073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2075352A Expired GB722467A (en) | 1952-08-18 | 1952-08-18 | Improvements in and relating to the manufacture of ª‰-n-morpholinoethylmorphine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB722467A (en) |
-
1952
- 1952-08-18 GB GB2075352A patent/GB722467A/en not_active Expired
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