GB749093A - A process for the manufacture of 3:20-diketopregnane - Google Patents

A process for the manufacture of 3:20-diketopregnane

Info

Publication number
GB749093A
GB749093A GB2982953A GB2982953A GB749093A GB 749093 A GB749093 A GB 749093A GB 2982953 A GB2982953 A GB 2982953A GB 2982953 A GB2982953 A GB 2982953A GB 749093 A GB749093 A GB 749093A
Authority
GB
United Kingdom
Prior art keywords
prepared
diketopregnane
enol
manufacture
ketobisnorcholan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2982953A
Inventor
Joseph Green
Anthony Fenwick Daglish
Victor David Poole
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vitamins Ltd
Original Assignee
Vitamins Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitamins Ltd filed Critical Vitamins Ltd
Priority to GB2982953A priority Critical patent/GB749093A/en
Publication of GB749093A publication Critical patent/GB749093A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

3:20-Diketopregnane is prepared by ozonisation of a compound of the formula <FORM:0749093/IV(a)/1> where R is an acyl group. The enol esters can be prepared from the corresponding bisnorcholan-22-al by standard methods, e.g. refluxing with the appropriate acid anhydride and the corresponding sodium salt. In an example 3-ketobisnorcholan-22-al is refluxed with sodium acetate and acetic anhydride under nitrogen, the enol acetate produced extracted with chloroform and treated with ozonized oxygen at -50 DEG C. Decomposition of the ozonide with zinc dust and acetic acid yields 3:20-diketo-pregnane. Specification 748,975 is referred to.
GB2982953A 1953-10-28 1953-10-28 A process for the manufacture of 3:20-diketopregnane Expired GB749093A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2982953A GB749093A (en) 1953-10-28 1953-10-28 A process for the manufacture of 3:20-diketopregnane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2982953A GB749093A (en) 1953-10-28 1953-10-28 A process for the manufacture of 3:20-diketopregnane

Publications (1)

Publication Number Publication Date
GB749093A true GB749093A (en) 1956-05-16

Family

ID=10297863

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2982953A Expired GB749093A (en) 1953-10-28 1953-10-28 A process for the manufacture of 3:20-diketopregnane

Country Status (1)

Country Link
GB (1) GB749093A (en)

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