GB724256A - Improvements in the production of esters of pyridine carboxylic acids - Google Patents

Improvements in the production of esters of pyridine carboxylic acids

Info

Publication number
GB724256A
GB724256A GB31819/52A GB3181952A GB724256A GB 724256 A GB724256 A GB 724256A GB 31819/52 A GB31819/52 A GB 31819/52A GB 3181952 A GB3181952 A GB 3181952A GB 724256 A GB724256 A GB 724256A
Authority
GB
United Kingdom
Prior art keywords
acids
esters
carboxylic acids
alcohol
pyridine carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31819/52A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Badische Anilin and Sodafabrik AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE, Badische Anilin and Sodafabrik AG filed Critical BASF SE
Publication of GB724256A publication Critical patent/GB724256A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/803—Processes of preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

Esters of pyridine carboxylic acids are obtained by heating the acids with excess of a monohydric alcohol or with a polyhydric alcohol, without catalysts and without removal of the water formed, in pressure-vessels at about 120 DEG -200 DEG C. The excess of alcohol is distilled and the ester purified. In examples, the ethyl, n-butyl, cyclohexyl, and n-propyl esters of nicotinic and isonicotinic acids are prepared by this method. Other esters referred to include esters of the above acids, and also of chlorinated or brominated pyridine mono- or dicarboxylic acids, with methyl, hexyl, isopropyl and benzyl alcohols, glycols, glycol ethyl ether, glycerol, chloroalcohols and triethanolamine. Polyhydric alcohols may be esterified with one or more molecules of the same or different acids.
GB31819/52A 1951-12-17 1952-12-16 Improvements in the production of esters of pyridine carboxylic acids Expired GB724256A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE724256X 1951-12-17

Publications (1)

Publication Number Publication Date
GB724256A true GB724256A (en) 1955-02-16

Family

ID=6633984

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31819/52A Expired GB724256A (en) 1951-12-17 1952-12-16 Improvements in the production of esters of pyridine carboxylic acids

Country Status (1)

Country Link
GB (1) GB724256A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2816112A (en) * 1954-05-28 1957-12-10 Nopco Chem Co Non-catalytic preparation of nicotinic acid esters
US2836601A (en) * 1956-02-09 1958-05-27 Warner Lambert Pharmaceutical Decarboxylation treatment
US2878253A (en) * 1959-03-17 Certificate of correction
US2878251A (en) * 1959-03-17 Nicotinic acid ester of y-oxyethyl
US2891067A (en) * 1957-02-08 1959-06-16 Albert David Ltd Preparation of isonicotinic acid hydrazide
DE1198822B (en) * 1956-03-15 1965-08-19 Aries Associates Inc Process for the preparation of alkyl esters of pyridinecarboxylic acids

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2878253A (en) * 1959-03-17 Certificate of correction
US2878251A (en) * 1959-03-17 Nicotinic acid ester of y-oxyethyl
US2816112A (en) * 1954-05-28 1957-12-10 Nopco Chem Co Non-catalytic preparation of nicotinic acid esters
US2836601A (en) * 1956-02-09 1958-05-27 Warner Lambert Pharmaceutical Decarboxylation treatment
DE1198822B (en) * 1956-03-15 1965-08-19 Aries Associates Inc Process for the preparation of alkyl esters of pyridinecarboxylic acids
US2891067A (en) * 1957-02-08 1959-06-16 Albert David Ltd Preparation of isonicotinic acid hydrazide

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