GB708020A - Improvements relating to compounds of the cyclopentanodimethylpolyhydrophenanthrene series - Google Patents

Improvements relating to compounds of the cyclopentanodimethylpolyhydrophenanthrene series

Info

Publication number
GB708020A
GB708020A GB21857/51A GB2185751A GB708020A GB 708020 A GB708020 A GB 708020A GB 21857/51 A GB21857/51 A GB 21857/51A GB 2185751 A GB2185751 A GB 2185751A GB 708020 A GB708020 A GB 708020A
Authority
GB
United Kingdom
Prior art keywords
radical
androstatriene
separating
positions
heating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB21857/51A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB708020A publication Critical patent/GB708020A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0708020/IV (b)/1> wherein R is hydrogen, acyl or an aroyl radical, R11 is the radical >C = O or <FORM:0708020/IV (b)/2> and R1 is a hydroxy, acyloxy or aryloxy radical and their preparation by heating the corresponding D 5.7 androstadiene with mercuric acetate and acetic acid in the presence of a lower aliphatic alcohol containing from 1 to 6 carbon atoms per molecule, separating the product, and if desired hydrolysing any ester groups in the 3 and/or 17 positions. The reaction may be effected in the temperature range 50 DEG C. to 125 DEG C. In examples the production of D 5.7.9-androstatriene-3b , 17b -diol and D 5.7.9-androstatriene - 3b - ol - 17 - one and its acetate are described. D 5.7-androstadienes are obtained from the corresponding 7.8 - dihydroandrostadienes by heating with N-bromosuccimide and a tertiary amine in the presence of a saturated hydrocarbon solvent, separating the product, and if desired hydrolysing any ester groups in the 3 and/or 17 positions.
GB21857/51A 1950-10-27 1951-09-18 Improvements relating to compounds of the cyclopentanodimethylpolyhydrophenanthrene series Expired GB708020A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US708020XA 1950-10-27 1950-10-27

Publications (1)

Publication Number Publication Date
GB708020A true GB708020A (en) 1954-04-28

Family

ID=22097473

Family Applications (1)

Application Number Title Priority Date Filing Date
GB21857/51A Expired GB708020A (en) 1950-10-27 1951-09-18 Improvements relating to compounds of the cyclopentanodimethylpolyhydrophenanthrene series

Country Status (1)

Country Link
GB (1) GB708020A (en)

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