GB715939A - Improvements in or relating to cyclopentanopolyhydrophenanthrene compounds and methods of production thereof - Google Patents
Improvements in or relating to cyclopentanopolyhydrophenanthrene compounds and methods of production thereofInfo
- Publication number
- GB715939A GB715939A GB24995/53A GB2499553A GB715939A GB 715939 A GB715939 A GB 715939A GB 24995/53 A GB24995/53 A GB 24995/53A GB 2499553 A GB2499553 A GB 2499553A GB 715939 A GB715939 A GB 715939A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- compounds
- saponification
- manufacture
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises 1-methylestrogen compounds of the probable general formul <FORM:0715939/IV (b)/1> and <FORM:0715939/IV (b)/2> (wherein Rx represents an acetyl or propiony group, B represents C = O or CH-ORy, Ry represents the residue of a fatty acid of not more than 6 carbon atoms or of an aromatic acid, and D represents C = O or CH-OH), the manufacture thereof by catalytic hydrogenation of the corresponding 1-methyl-D 6-dehydroestrogen compounds obtainable by the process of Specification 715,884, and the manufacture of (II) by saponification of (I). The products, which are characterized by solubility in alkali, possess estrogenic properties. In examples (1) 1-methyl-D 6-dehydroestrone acetate is shaken with hydrogen in ethyl acetate in the presence of palladium-on-charcoal catalyst; (2) the product of (1) is saponified; (3) 1-methyl-D 6-dehydroestradiol 3 : 17-diacetate is hydrogenated as in (1), or in the presence of barium sulphate supported catalyst; (4) 1-methylestradiol is prepared by saponification of the product of (3) or by hydrogenation of 1-methyl-D 6-dehydroestrodiol. Specification 715,883 also is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US715939XA | 1950-03-31 | 1950-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB715939A true GB715939A (en) | 1954-09-22 |
Family
ID=22102323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB24995/53A Expired GB715939A (en) | 1950-03-31 | 1950-12-19 | Improvements in or relating to cyclopentanopolyhydrophenanthrene compounds and methods of production thereof |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB715939A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2863862A (en) * | 1954-12-10 | 1958-12-09 | Syntex Sa | 1-methyl steroid derivatives and method for the production thereof |
-
1950
- 1950-12-19 GB GB24995/53A patent/GB715939A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2863862A (en) * | 1954-12-10 | 1958-12-09 | Syntex Sa | 1-methyl steroid derivatives and method for the production thereof |
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