GB658467A - Improvements relating to the production of preparations of penicillin salts - Google Patents
Improvements relating to the production of preparations of penicillin saltsInfo
- Publication number
- GB658467A GB658467A GB24781/49A GB2478149A GB658467A GB 658467 A GB658467 A GB 658467A GB 24781/49 A GB24781/49 A GB 24781/49A GB 2478149 A GB2478149 A GB 2478149A GB 658467 A GB658467 A GB 658467A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- salt
- water
- preparations
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/22—Salts with organic bases; Complexes with organic compounds
- C07D499/24—Salts with organic bases; Complexes with organic compounds with acyclic or carbocyclic compounds containing amino radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Preparations of penicillin salts difficulty soluble in water, which preparations contain water, or in which the penicillin salt in the course of production comes into contact with water, are stabilized by dissolving in the aqueous phase the cation of the penicillin salt so that there is present an excess of the cation of the penicillin salt over and above that combined in the penicillin salt. Such salts are procaine penicillin and aluminium penicillin. The aqueous solution may contain other substances such as hydrophyllic colloids, e.g. carboxymethyl cellulose, carboxymethyl starch, alkali metal salts of alginic acid and pectins and amylopectin, alkali metal salts, e.g. sodium chloride, and preservatives, e.g. methyl p-hydroxybenzoate. An example is given of a procaine penicillin injection in which the said salt is suspended in an aqueous solution of procaine hydrochloride, sodium carboxymethyl cellulose, sodium chloride and methyl p-hydroxybenzoate.ALSO:Preparations of penicillin salts difficultly soluble in water, which preparations contain water, or in which the penicillin salt in the course of production comes into contact with water, are characterized in that to the aqueous phase is added the cation of the penicillin salt so that there is present an excess of the cation of the penicillin salt over and above that combined in the penicillin salt. Such salts are procaine penicillin and aluminium penicillin. The aqueous solution may contain other substances such as hydrophillic colloids, e.g. carboxymethyl cellulose carboxymethyl starch alkali metal salts of alginic acid and pectins and amylopectin, alkali metal salts, e.g. sodium chloride and preserving agents, e.g. methyl p-hydroxybenzoate. An example is given of a procaine penicillin injection in which the said salt is suspended in an aqueous solution of procaine hydrochloride, sodium carboxymethyl cellulose, sodium chloride and methyl p-hydroxybenzoate. The preparations may be water-containing ointments, injections and lozenges.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE658467X | 1949-09-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB658467A true GB658467A (en) | 1951-10-10 |
Family
ID=20314248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB24781/49A Expired GB658467A (en) | 1949-09-09 | 1949-09-27 | Improvements relating to the production of preparations of penicillin salts |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB658467A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2715092A (en) * | 1951-04-06 | 1955-08-09 | Chimiotherapie Lab Franc | Organic penicillin salt solutions and method of making same |
US2731387A (en) * | 1951-05-15 | 1956-01-17 | Schenley Ind Inc | Aqueous suspension of procaine penicillin |
US2734845A (en) * | 1956-02-14 | Aqueous suspension of procaine penicil- | ||
US2734846A (en) * | 1956-02-14 | Aqueous suspension of procaine penicil- | ||
US2738300A (en) * | 1954-12-24 | 1956-03-13 | Smith Kline French Lab | Stable aqueous penicillin preparation |
US2749274A (en) * | 1952-05-06 | 1956-06-05 | Bristol Lab Inc | Stable aqueous procaine penicillin suspension |
US2870063A (en) * | 1955-07-05 | 1959-01-20 | Mallinckrodt Chemical Works | X-ray contrast composition comprising substantially amylose-free amylopectin in aqueous solution of contrast agent |
US2903395A (en) * | 1956-03-30 | 1959-09-08 | Pfizer & Co C | Aqueous calcium dioxytetracycline antibiotic composition |
EP1190719A1 (en) * | 2000-08-17 | 2002-03-27 | B. Braun Melsungen Ag | Colloidal pharmacomodulation of injected pharmaceutical compositions |
-
1949
- 1949-09-27 GB GB24781/49A patent/GB658467A/en not_active Expired
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2734845A (en) * | 1956-02-14 | Aqueous suspension of procaine penicil- | ||
US2734846A (en) * | 1956-02-14 | Aqueous suspension of procaine penicil- | ||
US2715092A (en) * | 1951-04-06 | 1955-08-09 | Chimiotherapie Lab Franc | Organic penicillin salt solutions and method of making same |
US2731387A (en) * | 1951-05-15 | 1956-01-17 | Schenley Ind Inc | Aqueous suspension of procaine penicillin |
US2749274A (en) * | 1952-05-06 | 1956-06-05 | Bristol Lab Inc | Stable aqueous procaine penicillin suspension |
US2738300A (en) * | 1954-12-24 | 1956-03-13 | Smith Kline French Lab | Stable aqueous penicillin preparation |
US2870063A (en) * | 1955-07-05 | 1959-01-20 | Mallinckrodt Chemical Works | X-ray contrast composition comprising substantially amylose-free amylopectin in aqueous solution of contrast agent |
US2903395A (en) * | 1956-03-30 | 1959-09-08 | Pfizer & Co C | Aqueous calcium dioxytetracycline antibiotic composition |
EP1190719A1 (en) * | 2000-08-17 | 2002-03-27 | B. Braun Melsungen Ag | Colloidal pharmacomodulation of injected pharmaceutical compositions |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB658467A (en) | Improvements relating to the production of preparations of penicillin salts | |
GB1415023A (en) | Thiamphenicol derivatives | |
GB748024A (en) | Improved therapeutic preparations of iron | |
FR913493A (en) | electrolyser for alkaline salt solutions | |
GB739800A (en) | Aqueous pharmaceutical solutions of reserpine for parenteral administration | |
GB613080A (en) | Improvements in the preparation of stable medicinal salts of acetylsalicylic acid | |
GB1060133A (en) | A derivative of -aminobenzylpenicillin | |
GB816592A (en) | A method for the preparation of stable magnesium solutions of high concentration | |
GB568858A (en) | A process for the manufacture of a cumarin derivative | |
GB681140A (en) | Preparation of crystal forms of procaine-benzylpenicillin suitable for use in parenteral suspensions by the use of methyl cellulose | |
GB642457A (en) | Improvements in or relating to the preparation of organo antimony derivatives | |
GB782715A (en) | Process for the preparation of lead azide | |
GB204721A (en) | Manufacture of arsenobenzene derivatives | |
GB547409A (en) | Process for the preparation of 4-acetamido-2-hydroxyphenylarsenoxide | |
GB613367A (en) | Process for the preparation of 2-alkyloxy-or-alkenyloxy-5-nitro anilines and their salts | |
GB773557A (en) | Improvements in or relating to a process for the preparation of therapeutic compositions having prolonged activity and compositions formed thereby | |
GB678508A (en) | Preparation of crystalline benzylpenicillinic acid-diisopropyl etherate | |
GB758052A (en) | Composition or double salts comprising calcium quinate and calcium gluconate or levulinate | |
ES391439A1 (en) | A procedure for preparing a detergent composition. (Machine-translation by Google Translate, not legally binding) | |
GB573478A (en) | Improvements in or relating to the manufacture of chlorocresol derivatives | |
AU146273B2 (en) | Improvements in or relating to method of stabilizing aqueous solution of vitamin B1 and stabilized solutions resulting therefrom | |
GB720166A (en) | Method of preparing the tri-p-aminosalicylate of dihydrostreptomycin | |
GB439935A (en) | Process for the manufacture of stable solutions of dihydroxy-diamino-arsenobenzene and its derivatives | |
ES217930A1 (en) | A procedure for obtaining mono-, di- or poly-hydroxy-alcohylxyantins and their nitric esters (Machine-translation by Google Translate, not legally binding) | |
GB695594A (en) | Improvements in or relating to salts of theobromine-laevulinic acid compounds |