GB597936A - Improvements in or relating to the manufacture of mono-calcium citrate dihydrate - Google Patents

Improvements in or relating to the manufacture of mono-calcium citrate dihydrate

Info

Publication number
GB597936A
GB597936A GB23363/44A GB2336344A GB597936A GB 597936 A GB597936 A GB 597936A GB 23363/44 A GB23363/44 A GB 23363/44A GB 2336344 A GB2336344 A GB 2336344A GB 597936 A GB597936 A GB 597936A
Authority
GB
United Kingdom
Prior art keywords
citric acid
calcium citrate
calcium
mono
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23363/44A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB597936A publication Critical patent/GB597936A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Solid mono-calcium citrate dihydrate is prepared by mixing one mole. of solid calcium oxide, hydroxide or carbonate with at least two moles. of anhydrous or hydrated citric acid and only sufficient water to provide a fluid paste whereby reaction ensues with the generation of heat, the mixture being transformed into a solid cake of mono-calcium citrate dihydrate and any excess of citric acid over said two moles. To obtain a wholly water-soluble product a proportion of at least 2.1 moles. of citric acid is used. The cake of calcium citrate may be freed from water or excess citric acid or both by treatment with a non-aqueous organic solvent in which the citrate is insoluble, for example, acetone, methyl to amyl alcohols and various ethylene glycol and diethylene glycol monoalkyl ethers. The calcium citrate may be used in baking powders and pharmaceutical remedies (see Group VI). Examples describe the preparation of calcium citrate with or without citric acid by mixing 1 mol. calcium carbonate and varying amounts from 2 to 3.1 moles. of anhydrous citric acid with water to form a paste and drying the resulting cake, substantially pure mono-calcium citrate being obtained by retracting excess citric acid, when present, with acetone.ALSO:Internal remedies comprise mono-calcium citrate dihydrate, with or without citric acid, and a salt of carbonic acid, for example, sodium bicarbonate, alone or with an acidic phosphate such as calcium phosphate. The compositions give effervescent solutions in water. The monocalcium citrate dihydrate, whose preparation is described (see Group IV), may be used alone or with citric acid as a baking powder component. Specifications 597,937 and 597,938 are referred to.
GB23363/44A 1943-11-08 1944-11-23 Improvements in or relating to the manufacture of mono-calcium citrate dihydrate Expired GB597936A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US597936XA 1943-11-08 1943-11-08

Publications (1)

Publication Number Publication Date
GB597936A true GB597936A (en) 1948-02-06

Family

ID=22025258

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23363/44A Expired GB597936A (en) 1943-11-08 1944-11-23 Improvements in or relating to the manufacture of mono-calcium citrate dihydrate

Country Status (2)

Country Link
BE (1) BE597936A (en)
GB (1) GB597936A (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2051492A1 (en) * 1969-03-26 1971-04-09 Organon Nv
WO1987005507A1 (en) * 1986-03-18 1987-09-24 Board Of Regents, The University Of Texas System Ultradense and more soluble and bioavailable preparations of calcium citrate
US4772467A (en) * 1985-02-19 1988-09-20 Board Of Regents, U T Systems Osteoporosis inhibition by dietary calcium supplementation
US4851221A (en) * 1985-02-19 1989-07-25 Mission Pharmacal Company Liquid calcium supplementation from readily soluble mixtures of calcium compound and citric acid
EP1566373A1 (en) * 2004-02-18 2005-08-24 Kraft Foods Holdings, Inc. Amorphous water-soluble calcium citrate salts and method of making and using same.
WO2005123648A1 (en) 2004-06-08 2005-12-29 Tate & Lyle Ingredients Americas, Inc. Highly soluble form of tricalcium citrate, and methods of its making and use
US7781002B2 (en) 2003-02-28 2010-08-24 Kraft Foods Global Brands Llc Mineral complexes of lactobionic acid and method of using for mineral fortification of food products
CN102329288A (en) * 2011-08-16 2012-01-25 山东恒通生物科技有限公司 Method for preparing taurine VC calcium citrate
CN102557920A (en) * 2011-12-22 2012-07-11 日照金禾博源生化有限公司 Process for producing calcium citrate
CN102863327A (en) * 2012-09-21 2013-01-09 中粮生物化学（安徽）股份有限公司 Production device and production method of calcium citrate
CN101348431B (en) * 2007-07-20 2013-03-27 南通市飞宇精细化学品有限公司 Method for producing low lead light density granular calcium citrate
US8496982B2 (en) 2006-03-22 2013-07-30 Gadot Biochemical Industries Ltd Calcium enrichment compositions method of production thereof and use

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2051492A1 (en) * 1969-03-26 1971-04-09 Organon Nv
US4772467A (en) * 1985-02-19 1988-09-20 Board Of Regents, U T Systems Osteoporosis inhibition by dietary calcium supplementation
US4851221A (en) * 1985-02-19 1989-07-25 Mission Pharmacal Company Liquid calcium supplementation from readily soluble mixtures of calcium compound and citric acid
WO1987005507A1 (en) * 1986-03-18 1987-09-24 Board Of Regents, The University Of Texas System Ultradense and more soluble and bioavailable preparations of calcium citrate
US4814177A (en) * 1986-03-18 1989-03-21 Board Of Regents, University Of Texas System Ultradense and more soluble and bioavailable preparations of calcium citrate
US7781002B2 (en) 2003-02-28 2010-08-24 Kraft Foods Global Brands Llc Mineral complexes of lactobionic acid and method of using for mineral fortification of food products
US7713559B2 (en) 2004-02-18 2010-05-11 Kraft Foods Global Brands Llc Amorphous water-soluble calcium citrate salts and method of making and using same
EP1566373A1 (en) * 2004-02-18 2005-08-24 Kraft Foods Holdings, Inc. Amorphous water-soluble calcium citrate salts and method of making and using same.
US7267832B2 (en) 2004-02-18 2007-09-11 Kraft Foods Holdings, Inc. Amorphous water-soluble calcium citrate salts and method of making and using same
US7323201B2 (en) 2004-06-08 2008-01-29 Tate & Lyle Ingredients Americas, Inc. Highly soluble form of tricalcium citrate, and methods of its making and use
US7781003B2 (en) 2004-06-08 2010-08-24 Tate & Lyle Ingredients Americas, Inc. Highly soluble form of tricalcium citrate, and methods of its making and use
WO2005123648A1 (en) 2004-06-08 2005-12-29 Tate & Lyle Ingredients Americas, Inc. Highly soluble form of tricalcium citrate, and methods of its making and use
US8496982B2 (en) 2006-03-22 2013-07-30 Gadot Biochemical Industries Ltd Calcium enrichment compositions method of production thereof and use
CN101348431B (en) * 2007-07-20 2013-03-27 南通市飞宇精细化学品有限公司 Method for producing low lead light density granular calcium citrate
CN102329288A (en) * 2011-08-16 2012-01-25 山东恒通生物科技有限公司 Method for preparing taurine VC calcium citrate
CN102557920A (en) * 2011-12-22 2012-07-11 日照金禾博源生化有限公司 Process for producing calcium citrate
CN102863327A (en) * 2012-09-21 2013-01-09 中粮生物化学（安徽）股份有限公司 Production device and production method of calcium citrate
CN102863327B (en) * 2012-09-21 2015-01-07 中粮生物化学（安徽）股份有限公司 Production device and production method of calcium citrate

Also Published As

Publication number Publication date
BE597936A (en) 1961-06-08

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