GB577396A - Process of recovering alkaloids - Google Patents

Process of recovering alkaloids

Info

Publication number
GB577396A
GB577396A GB7708/44A GB770844A GB577396A GB 577396 A GB577396 A GB 577396A GB 7708/44 A GB7708/44 A GB 7708/44A GB 770844 A GB770844 A GB 770844A GB 577396 A GB577396 A GB 577396A
Authority
GB
United Kingdom
Prior art keywords
theobromine
caffeine
clay
adsorbed
desorption
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7708/44A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Foods Corp
Original Assignee
General Foods Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Foods Corp filed Critical General Foods Corp
Publication of GB577396A publication Critical patent/GB577396A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Theobromine is recovered from its aqueous solutions by adsorbing it on clay from an aqueous solution having a pH not substantially greater than 8.5. Caffeine, if present, is also adsorbed on the clay at the same time. The theobromine may be removed from the clay by desorbing it with an aqueous solution having a pH not substantially less than 10.5. If caffeine is present, the alkaloids may be separated by preferentially desorbing one of them and then the other, the theobromine being desorbed as above and the caffeine being desorbed by a non-chlorinated organic solvent of relatively high dipole moment or with a mixture of such solvents or of such a solvent with other organic or inorganic solvents. Examples are given which illustrate (a) the effectiveness with which theobromine is adsorbed on clay from solutions, the pH values of which are less than 8.5; (b) the effect of pH variation on such adsorption; (c) the effectiveness with which both caffeine and theobromine can be adsorbed on clay; (d) the desorption of theobromine from clay by trisodium phosphate and sodium hydroxide solutions of varying pH values; (e) the ineffectiveness of caffeine desorption by these solutions; (f) the desorption of caffeine from clay by various solvents and solvent mixtures; (g) the ineffectiveness of theobromine desorption by these solvents; and (h) the effectiveness with which theobromine and caffeine can be adsorbed on clay from their aqueous solutions and then separated and recovered independently by preferential desorption. In the above examples, various grades of fuller's earth are specified for use as adsorbent. Solvents specified for desorbing caffeine are methyl and ethyl alcohols, acetone, methyl acetate, pyridine, aniline, piperidine, ethanolamine, diethanolamine and mixtures of methyl alcohol and acetone, methyl acetone, trichlorethylene dichlormethane or chloroform and of methyl alcohol, acetone and methyl acetate, dichlormethane, chloroform or water. The application of the invention to cocoa waste extracts or to the mother liquor remaining after crystallisation of part of the theobromine from such extracts, is described with reference to an accompanying flow sheet. The process is applicable where the theobromine in the cocoa waste extract is in the form of a metal salt, e.g. where the extraction has been carried out in presence of lime or other alkali, the theobromine being adsorbed as free alkaloid.
GB7708/44A 1943-05-07 1944-04-25 Process of recovering alkaloids Expired GB577396A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US577396XA 1943-05-07 1943-05-07

Publications (1)

Publication Number Publication Date
GB577396A true GB577396A (en) 1946-05-16

Family

ID=22012459

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7708/44A Expired GB577396A (en) 1943-05-07 1944-04-25 Process of recovering alkaloids

Country Status (1)

Country Link
GB (1) GB577396A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0066700A1 (en) * 1981-05-21 1982-12-15 Societe Des Produits Nestle S.A. Recovery of xanthine stimulants from aqueous media
EP0070437A1 (en) * 1981-07-22 1983-01-26 Societe Des Produits Nestle S.A. Process for the elimination of stimulant compounds from cocoa

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0066700A1 (en) * 1981-05-21 1982-12-15 Societe Des Produits Nestle S.A. Recovery of xanthine stimulants from aqueous media
EP0070437A1 (en) * 1981-07-22 1983-01-26 Societe Des Produits Nestle S.A. Process for the elimination of stimulant compounds from cocoa

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