GB362023A - Process for the production of extracts serving for therapeutic purposes and for increasing the vitamin content of foodstuffs - Google Patents

Process for the production of extracts serving for therapeutic purposes and for increasing the vitamin content of foodstuffs

Info

Publication number
GB362023A
GB362023A GB27193/30A GB2719330A GB362023A GB 362023 A GB362023 A GB 362023A GB 27193/30 A GB27193/30 A GB 27193/30A GB 2719330 A GB2719330 A GB 2719330A GB 362023 A GB362023 A GB 362023A
Authority
GB
United Kingdom
Prior art keywords
acetone
petroleum spirit
nitrogen
alcohol
washed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27193/30A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MATRO GmbH
Original Assignee
MATRO GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MATRO GmbH filed Critical MATRO GmbH
Publication of GB362023A publication Critical patent/GB362023A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Vitamin concentrates suitable for therapeutic purposes or for addition to foodstuffs are obtained by extracting rootlets of grain or maize, germinated in malting, with ethyl alcohol or fat solvents, wholly freeing the extracts from the solvents, treating the residues with saponifying agents, precipitating the soaps, concentrating the filtrates and treating the residues with fat solvents, separating substances rich in vitamins from the solutions, for example, by freezing, and if desired dividing the product into fractions by means of petroleum spirit, or other fat solvent. The manipulations following the precipitation of the soaps should be performed in an atmosphere free from oxygen, for example in a current or atmosphere of an inert gas such as nitrogen. Fat solvents mentioned are acetone, ether, petroleum spirit, carbon disulphide, benzene, chloroform, carbon tetrachloride, trichlorethylene, liquid carbon dioxide, amyl alcohol, or mixtures thereof. According to an example, air-dried rootlets are extracted with a mixture of acetone and petroleum spirit. The extract is concentrated under reduced pressure to the consistency of a syrup, mixed with hot alcohol, and, if desired after filtration from the undissolved portion, treated with alcoholic soda or potash, or sodium alcoholate. The soaps formed are precipitated with alcoholic calcium chloride solution and removed by filtration. The solution is freed from alcohol by evaporation under reduced pressure, the residue extracted with warm acetone, the acetone evaporated, the residue redissolved in acetone, and the solution cooled to 20 DEG C. in an atmosphere of dry nitrogen saturated with acetone vapour. The precipitated mass is washed with acetone and then extracted with warm petroleum spirit. The extract thus obtained is frozen at 20 DEG C., and the crystals obtained aspirated in nitrogen and washed in acetone at 20 DEG C. These crystals and finally the residue left on evaporating the petroleum spirit mother liquor are dried in vacuo, dissolved in ethyl alcohol freed from air by means of nitrogen, and the solutions kept in hermetically sealed bottles. Specification 328,942, [Class 2 (iii), Dyes &c.], is referred to. The Specification as open to inspection under Sect. 91 (3) (a) comprises also another example, in which the insoluble soap is washed with ether, and the washings added to the alcoholic solution separated from the soap. This subject-matter does not appear in the Specification as accepted.ALSO:Vitamin concentrates suitable for therapeutic purposes or for addition to foodstuffs are obtained by extracting rootlets of grain or maize, germinated in malting, with ethyl alcohol or fat solvents, wholly freeing the extracts from the solvents, treating the residues with saponifying agents, precipitating the soaps, concentrating the filtrates and treating the residues with fat solvents, separating substances rich in vitamins from the solutions, for example by freezing, and if desired dividing the product into fractions by means of petroleum spirit, or other fat solvent. The manipulations following the precipitation of the soaps should be performed in an atmosphere free from oxygen, for example in a current or atmosphere of an inert gas such as nitrogen. Fat solvents mentioned are acetone, ether, petroleum spirit, carbon disulphide, benzene, chloroform, carbon tetrachloride, trichlorethylene, liquid carbon dioxide, amyl alcohol, or mixtures thereof. According to an example, air-dried rootlets are extracted with a mixture of acetone and petroleum spirit. The extract is concentrated under reduced pressure to the consistency of a syrup, mixed with hot alcohol, and, if desired after filtration from the undissolved portion, treated with alcoholic soda or potash, or sodium alcoholate. The soaps formed are precipitated with alcoholic calcium chloride solution and removed by filtration. The solution is freed from alcohol by evaporation under reduced pressure, the residue extracted with warm acetone, the acetone evaporated, the residue redissolved in acetone, and the solution cooled to 20 DEG C. in an atmosphere of dry nitrogen saturated with acetone vapour. The precipitated mass is washed with acetone and then extracted with warm petroleum spirit. The extract thus obtained is frozen out at -20 DEG C., and the crystals obtained aspirated in nitrogen and washed in acetone at -20 DEG C. These crystals and finally the residue left on evaporating the petroleum spirit mother liquor are dried in vacuo, dissolved in ethyl alcohol freed from air by means of nitrogen, and the solutions kept in hermetically sealed bottles. Specification 328,942, [Class 14 (ii), Beverages &c.], is referred to. The Specification as open to inspection under Sect. 91 (3) (a) comprises also another example, in which the insoluble soap is washed with ether, and the washings added to the alcoholic solution separated from the soap. This subject-matter does not appear in the Specification as accepted.
GB27193/30A 1929-09-12 1930-09-11 Process for the production of extracts serving for therapeutic purposes and for increasing the vitamin content of foodstuffs Expired GB362023A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE362023X 1929-09-12

Publications (1)

Publication Number Publication Date
GB362023A true GB362023A (en) 1931-12-03

Family

ID=6303113

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27193/30A Expired GB362023A (en) 1929-09-12 1930-09-11 Process for the production of extracts serving for therapeutic purposes and for increasing the vitamin content of foodstuffs

Country Status (1)

Country Link
GB (1) GB362023A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113403348A (en) * 2021-06-18 2021-09-17 山东润德生物科技有限公司 Preparation method of vitamin K2

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113403348A (en) * 2021-06-18 2021-09-17 山东润德生物科技有限公司 Preparation method of vitamin K2
CN113403348B (en) * 2021-06-18 2022-03-22 山东润德生物科技有限公司 Preparation method of vitamin K2

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