GB851777A - Process for obtaining active material from ovaries and placental tissue - Google Patents

Process for obtaining active material from ovaries and placental tissue

Info

Publication number
GB851777A
GB851777A GB33624/58A GB3362458A GB851777A GB 851777 A GB851777 A GB 851777A GB 33624/58 A GB33624/58 A GB 33624/58A GB 3362458 A GB3362458 A GB 3362458A GB 851777 A GB851777 A GB 851777A
Authority
GB
United Kingdom
Prior art keywords
active substance
ovaries
solvent
placental tissue
organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33624/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB851777A publication Critical patent/GB851777A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2221—Relaxins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

An active substance stated to comprise both the "Uterine Relaxing" (UR-) factor and Relaxin is obtained from ovaries (especially of pigs) or placental tissue by extraction with 0,01 to 1,0 N (preferably 0,05 to 0,5 N) aqueous acid containing 0 to 80% of an organic, water-miscible solvent and precipitating the active substance from the extract by the addition of from 4 to 10 volumes of a water-miscible organic solvent which may be the same as used in the extracting mixture or different. The process may be carried out as a batch process or as a continuous process in which commesuited material may be intimately mixed with barium sulphate in the ratio of 5:1 and the mixture extracted in a series of columns, that having been extracted the longest being replaced periodically. Specified organic solvents are acetone, methanol, ethanol, dioxain, tetrahydrofuran, acetonitrile. Specified acids are hydrochloric, sulphuric acetic and phosphoric acids. The preferred solvent is acetone containing from 20 to 90% by volume of 0,05 to 0,4 N aqueous hydrochloric acid. If the content of organic solvent is zero the aqueous acid is preferably 0,05 to 0,5 N. Characteristics of the I/R absorption spectrum of the active substance are given.
GB33624/58A 1957-10-21 1958-10-21 Process for obtaining active material from ovaries and placental tissue Expired GB851777A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE851777X 1957-10-21

Publications (1)

Publication Number Publication Date
GB851777A true GB851777A (en) 1960-10-19

Family

ID=6782262

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33624/58A Expired GB851777A (en) 1957-10-21 1958-10-21 Process for obtaining active material from ovaries and placental tissue

Country Status (1)

Country Link
GB (1) GB851777A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124900A (en) * 1982-12-10 1984-02-29 Cubana Importadora Y Exportado Product for stimulating the synthesis of melanotic pigment in the skin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124900A (en) * 1982-12-10 1984-02-29 Cubana Importadora Y Exportado Product for stimulating the synthesis of melanotic pigment in the skin

Similar Documents

Publication Publication Date Title
GB851777A (en) Process for obtaining active material from ovaries and placental tissue
JPS56120621A (en) Preparation of substance having wound remedying action
US3008878A (en) Process for the recovery of ur-factor and relaxin
US1969608A (en) Process for the manufacture of oestrus hormone
GB900572A (en) Funtumia alkaloids
Farmer et al. Isolation of a saponin from the heart-wood of the Mora tree and of a related species, Morabukea
GB925812A (en) Novel ester of hydroxymethylfurfural and process for its preparation
GB951663A (en) Process for the preparation of 6-deoxy-6-demethyl-6-methylene-5-oxytetracycline
Debska Separation and determination of the dissociation constants of chelidonine and protopine by paper chromatography
SU135186A2 (en) Method of extpactioh of antifungi nistatine antnbiotic from actinomycet micelline
US3136757A (en) Method for preparation of (3, 2-c)-isoxazoles
ES239181A1 (en) Procedure to facilitate the introduction of organic acids in tissues or organic cells and organic acids appropriate to this end (Machine-translation by Google Translate, not legally binding)
GB255689A (en) Process for the manufacture of the pure glucoside of bulbus scillae
GB645055A (en) Method for recovering bitumen contained in peat
GB948485A (en) New alkaloids and other new compounds from holarrhena species and processes for obtaining the same
ES255768A2 (en) Procedure for the obtaining of alcaloids and basic principles that may constitute steroids (Machine-translation by Google Translate, not legally binding)
GB753564A (en) Process for extracting impurities from waste acetic acid in the manufacture of acetyl-celluloses
ES200680A1 (en) Procedure and apparatus for the extraction of acetic acid from its aqueous solutions by means of solvents (Machine-translation by Google Translate, not legally binding)
GB619065A (en) Improvements in or relating to a method of stabilising an aqueous solution of ascorbic acid (vitamin c)
CS208911B1 (en) Isolation method of alcaloids from ergot
DE1122062B (en) Process for the production of stable vitamin A esters
ES252508A1 (en) Procedure for the separation of a lactama from a mixture of acid reaction (Machine-translation by Google Translate, not legally binding)
GB769565A (en) Process for recovering concentrated formic acid from its dilute aqueous solutions
GB824518A (en) A process of preparing colourless maleic acid anhydride of high purity
Hosoi et al. Researches on the Production of Furfural and High α-Pulp from Hard Wood (I) On the Qualities of Pulp Obtained