GB460137A - Improvements relating to substances adapted to decrease blood pressure - Google Patents

Improvements relating to substances adapted to decrease blood pressure

Info

Publication number
GB460137A
GB460137A GB11620/35A GB1162035A GB460137A GB 460137 A GB460137 A GB 460137A GB 11620/35 A GB11620/35 A GB 11620/35A GB 1162035 A GB1162035 A GB 1162035A GB 460137 A GB460137 A GB 460137A
Authority
GB
United Kingdom
Prior art keywords
urine
alcohol
precipitate
treated
ether
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11620/35A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CARL LUDVIG HOLTMAN
Original Assignee
CARL LUDVIG HOLTMAN
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARL LUDVIG HOLTMAN filed Critical CARL LUDVIG HOLTMAN
Priority to GB11620/35A priority Critical patent/GB460137A/en
Publication of GB460137A publication Critical patent/GB460137A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland

Abstract

A substance producing a decrease in blood pressure and which is resistant to boiling is obtained from urine by a process involving boiling the urine, or a fraction thereof containing the active substance, before, during or after the employment of the methods normally employed for separating from urine hormones which are insoluble in lipoid solvents. These methods are precipitation, adsorption, or diffusion and may be used separately or in combination. Ovarial hormone, if present, may be separated, for instance, by extraction with ether or by precipitation with alcohol. According to examples: (1) urine is boiled, treated successively with barium chloride and sodium sulphate to precipitate impurities and then with a large quantity of methyl alcohol to precipitate the active substance which is then centrifuged, washed with alcohol and ether, and dried; (2) urine is boiled, evaporated to dryness, the dry residue washed with alcohol and ether, taken up in water and treated with methyl alcohol to precipitate the active substance; (3) urine is treated with methyl alcohol and the precipitate washed with alcohol and ether, dissolved in water, and the solution subjected to dialysis or electro-dialysis and finally boiled; (4) urine is treated with charcoal to adsorb impurities, filtered, boiled, and treated with methyl alcohol to give a precipitate containing the active substance which is washed and dried.
GB11620/35A 1935-04-15 1935-04-15 Improvements relating to substances adapted to decrease blood pressure Expired GB460137A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB11620/35A GB460137A (en) 1935-04-15 1935-04-15 Improvements relating to substances adapted to decrease blood pressure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB11620/35A GB460137A (en) 1935-04-15 1935-04-15 Improvements relating to substances adapted to decrease blood pressure

Publications (1)

Publication Number Publication Date
GB460137A true GB460137A (en) 1937-01-15

Family

ID=9989602

Family Applications (1)

Application Number Title Priority Date Filing Date
GB11620/35A Expired GB460137A (en) 1935-04-15 1935-04-15 Improvements relating to substances adapted to decrease blood pressure

Country Status (1)

Country Link
GB (1) GB460137A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2447363A (en) * 1945-06-15 1948-08-17 Harold M Rabinowitz Compound of urobilinogen and hippuric acid as antipressor
US2551205A (en) * 1943-08-20 1951-05-01 Ayerst Mckenna & Harrison Process for preparing oestrogenic hormones from urine

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2551205A (en) * 1943-08-20 1951-05-01 Ayerst Mckenna & Harrison Process for preparing oestrogenic hormones from urine
US2447363A (en) * 1945-06-15 1948-08-17 Harold M Rabinowitz Compound of urobilinogen and hippuric acid as antipressor

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