GB2374595A - Fused bicyclic or tricyclic amino acids - Google Patents

Fused bicyclic or tricyclic amino acids Download PDF

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Publication number
GB2374595A
GB2374595A GB0109635A GB0109635A GB2374595A GB 2374595 A GB2374595 A GB 2374595A GB 0109635 A GB0109635 A GB 0109635A GB 0109635 A GB0109635 A GB 0109635A GB 2374595 A GB2374595 A GB 2374595A
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GB
United Kingdom
Prior art keywords
bicyclo
acetic acid
ho2c
aminomethyl
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB0109635A
Other languages
English (en)
Other versions
GB0109635D0 (en
Inventor
Justin Stephen Bryans
David Clive Blakemore
Sophie Caroline Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority to GB0109635A priority Critical patent/GB2374595A/en
Publication of GB0109635D0 publication Critical patent/GB0109635D0/en
Priority to DO2002000372A priority patent/DOP2002000372A/es
Priority to UA2003109397A priority patent/UA74879C2/uk
Priority to CZ20032764A priority patent/CZ20032764A3/cs
Priority to MXPA03009532A priority patent/MXPA03009532A/es
Priority to EA200300952A priority patent/EA006396B1/ru
Priority to KR1020037013691A priority patent/KR100618743B1/ko
Priority to CNB028084454A priority patent/CN100354251C/zh
Priority to YU78803A priority patent/YU78803A/sh
Priority to HU0303808A priority patent/HUP0303808A2/hu
Priority to OA1200300270A priority patent/OA12504A/en
Priority to DE60235619T priority patent/DE60235619D1/de
Priority to EP02716996A priority patent/EP1379494B1/en
Priority to IL15793202A priority patent/IL157932A0/xx
Priority to EEP200300517A priority patent/EE200300517A/xx
Priority to APAP/P/2002/002521A priority patent/AP2002002521A0/en
Priority to PCT/IB2002/001146 priority patent/WO2002085839A1/en
Priority to PL02366406A priority patent/PL366406A1/xx
Priority to AT02716996T priority patent/ATE460392T1/de
Priority to CA002444053A priority patent/CA2444053C/en
Priority to BR0208922-0A priority patent/BR0208922A/pt
Priority to GE5323A priority patent/GEP20053545B/en
Priority to TNPCT/IB2002/001146A priority patent/TNSN03094A1/fr
Priority to JP2002583367A priority patent/JP4121858B2/ja
Priority to SK1282-2003A priority patent/SK12822003A3/sk
Priority to NZ528151A priority patent/NZ528151A/en
Priority to PA20028543501A priority patent/PA8543501A1/es
Priority to US10/124,210 priority patent/US6596900B2/en
Priority to PE2002000311A priority patent/PE20021031A1/es
Priority to MYPI20021397A priority patent/MY134865A/en
Priority to GT200200074A priority patent/GT200200074A/es
Priority to ARP020101425A priority patent/AR035861A1/es
Priority to TW091107950A priority patent/TWI262909B/zh
Publication of GB2374595A publication Critical patent/GB2374595A/en
Priority to ZA200307097A priority patent/ZA200307097B/en
Priority to IS6955A priority patent/IS6955A/is
Priority to BG108182A priority patent/BG108182A/bg
Priority to HR20030832A priority patent/HRP20030832A2/hr
Priority to EC2003004804A priority patent/ECSP034804A/es
Priority to MA27363A priority patent/MA27015A1/fr
Priority to NO20034642A priority patent/NO20034642L/no
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C07C45/676—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton by elimination of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/417—Saturated compounds containing a keto group being part of a ring polycyclic
    • C07C49/423—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system
    • C07C49/427—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/417—Saturated compounds containing a keto group being part of a ring polycyclic
    • C07C49/423—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system
    • C07C49/427—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system having two rings
    • C07C49/433—Saturated compounds containing a keto group being part of a ring polycyclic a keto group being part of a condensed ring system having two rings the condensed ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
    • C—CHEMISTRY; METALLURGY
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    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/22—All rings being cycloaliphatic the ring system containing eight carbon atoms, e.g. pentalene
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB0109635A 2001-04-19 2001-04-19 Fused bicyclic or tricyclic amino acids Withdrawn GB2374595A (en)

Priority Applications (40)

Application Number Priority Date Filing Date Title
GB0109635A GB2374595A (en) 2001-04-19 2001-04-19 Fused bicyclic or tricyclic amino acids
DO2002000372A DOP2002000372A (es) 2001-04-19 2002-03-04 Aminoacidos biciclicos o triciclicos condensados
UA2003109397A UA74879C2 (en) 2001-04-19 2002-03-04 Condesated bicyclic or tricyclic amino acids
NZ528151A NZ528151A (en) 2001-04-19 2002-04-03 Fused bicyclic or tricyclic amino acids
BR0208922-0A BR0208922A (pt) 2001-04-19 2002-04-03 Aminoácidos bicìclicos ou tricìclicos fundidos
TNPCT/IB2002/001146A TNSN03094A1 (fr) 2001-04-19 2002-04-03 Amino-acides condenses bicycliques ou tricycliques
EA200300952A EA006396B1 (ru) 2001-04-19 2002-04-03 Конденсированные бициклические аминокислоты
KR1020037013691A KR100618743B1 (ko) 2001-04-19 2002-04-03 융합된 비사이클릭 또는 트리사이클릭 아미노산
CNB028084454A CN100354251C (zh) 2001-04-19 2002-04-03 稠合二环或三环氨基酸
YU78803A YU78803A (sh) 2001-04-19 2002-04-03 Fuzija bicikličnih ili tricikličnih amino kiselina
HU0303808A HUP0303808A2 (hu) 2001-04-19 2002-04-03 Kondenzált biciklusos vagy triciklusos aminosavak, aljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
OA1200300270A OA12504A (en) 2001-04-19 2002-04-03 Fused bicyclic or tricyclic amino acids.
DE60235619T DE60235619D1 (de) 2001-04-19 2002-04-03 Kondensierte bizyklische oder trizyklische aminosäuren
EP02716996A EP1379494B1 (en) 2001-04-19 2002-04-03 Fused bicyclic or tricyclic amino acids
IL15793202A IL157932A0 (en) 2001-04-19 2002-04-03 Fused bicyclic or tricyclic amino acids
EEP200300517A EE200300517A (et) 2001-04-19 2002-04-03 Bitsüklilised või tritsüklilised kondenseerunud tuumadega aminohapped
APAP/P/2002/002521A AP2002002521A0 (en) 2001-04-19 2002-04-03 Fused bicyclic or tricyclic amino acids.
PCT/IB2002/001146 WO2002085839A1 (en) 2001-04-19 2002-04-03 Fused bicyclic or tricyclic amino acids
PL02366406A PL366406A1 (en) 2001-04-19 2002-04-03 Fused bicyclic or tricyclic amino acids
AT02716996T ATE460392T1 (de) 2001-04-19 2002-04-03 Kondensierte bizyklische oder trizyklische aminosäuren
CA002444053A CA2444053C (en) 2001-04-19 2002-04-03 Fused bicyclic or tricyclic amino acids
CZ20032764A CZ20032764A3 (cs) 2001-04-19 2002-04-03 Fúzní bicyklické nebo tricyklické aminokyseliny
GE5323A GEP20053545B (en) 2001-04-19 2002-04-03 Fused Bicyclic or Tricyclic Amino Acids
MXPA03009532A MXPA03009532A (es) 2001-04-19 2002-04-03 Aminoacidos biciclicos o triciclicos condensados.
JP2002583367A JP4121858B2 (ja) 2001-04-19 2002-04-03 縮合した二環式又は三環式アミノ酸
SK1282-2003A SK12822003A3 (sk) 2001-04-19 2002-04-03 Fúzne bicyklické alebo tricyklické aminokyseliny
PA20028543501A PA8543501A1 (es) 2001-04-19 2002-04-10 Aminoácidos bicíclicos o tricíclicos condensados
PE2002000311A PE20021031A1 (es) 2001-04-19 2002-04-16 Aminoacidos biciclicos o triciclicos condensados
US10/124,210 US6596900B2 (en) 2001-04-19 2002-04-16 Fused bicyclic or tricyclic amino acids
MYPI20021397A MY134865A (en) 2001-04-19 2002-04-17 Fused bicyclic or tricyclic amino acids
GT200200074A GT200200074A (es) 2001-04-19 2002-04-18 Aminoacidos biciclicos o triciclicos condensados
ARP020101425A AR035861A1 (es) 2001-04-19 2002-04-18 Compuestos aminoacidos biciclicos o triciclicos condensados, procedimiento de preparacion, composiciones farmaceuticas y su uso en la preparacion de medicamentos
TW091107950A TWI262909B (en) 2001-04-19 2002-04-18 Fused bicyclic or tricyclic amino acids
ZA200307097A ZA200307097B (en) 2001-04-19 2003-09-11 Fused bicyclic or tricyclic amino acids.
IS6955A IS6955A (is) 2001-04-19 2003-09-15 Samtengdar bísýklískar eða trísýklískar amínósýrur
BG108182A BG108182A (bg) 2001-04-19 2003-09-17 Кондензирани бициклени или трициклени аминокиселини
HR20030832A HRP20030832A2 (en) 2001-04-19 2003-10-14 Fused bicyclic or tricyclic amino acids
EC2003004804A ECSP034804A (es) 2001-04-19 2003-10-15 Aminoácidos bicíclicos o tricíclicos condensados
MA27363A MA27015A1 (fr) 2001-04-19 2003-10-16 Amino-acides condenses bicycliques ou tricycliques
NO20034642A NO20034642L (no) 2001-04-19 2003-10-17 Kondenserte bicykliske eller tricykliske aminosyrer

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GB0109635A GB2374595A (en) 2001-04-19 2001-04-19 Fused bicyclic or tricyclic amino acids

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GB0109635D0 GB0109635D0 (en) 2001-06-13
GB2374595A true GB2374595A (en) 2002-10-23

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DO (1) DOP2002000372A (zh)
EC (1) ECSP034804A (zh)
GB (1) GB2374595A (zh)
GT (1) GT200200074A (zh)
UA (1) UA74879C2 (zh)
ZA (1) ZA200307097B (zh)

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US7868043B2 (en) 2008-01-25 2011-01-11 Xenoport, Inc. Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US7872046B2 (en) 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
US8062870B2 (en) 2008-01-25 2011-11-22 Xenoport, Inc. Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
WO2014113299A1 (en) 2013-01-15 2014-07-24 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
US10654794B2 (en) 2016-09-14 2020-05-19 Sichuan Haiso Pharmaceutical Co., Ltd. Fused tricyclic Γ-amino acid derivative, preparation method therefor, and medical use thereof

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EP2657219B1 (en) * 2007-09-28 2014-12-10 Daiichi Sankyo Company, Limited Intermediate for producing bicyclic y-amino acid derivative
WO2017107907A1 (zh) * 2015-12-25 2017-06-29 四川海思科制药有限公司 稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用
WO2017114225A1 (zh) * 2015-12-31 2017-07-06 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用
CN106928080B (zh) * 2015-12-31 2020-12-25 四川海思科制药有限公司 稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用
TW202019871A (zh) * 2018-07-12 2020-06-01 大陸商四川海思科製藥有限公司 稠合三環γ-胺基酸衍生物鹽類之晶型、製備方法及其用途
WO2020029762A1 (zh) * 2018-08-09 2020-02-13 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物的制备方法及中间体
CN113316564B (zh) * 2019-01-30 2023-06-09 四川海思科制药有限公司 一种稠合三环氘代衍生物及其组合物和应用
WO2021043117A1 (zh) * 2019-09-03 2021-03-11 四川海思科制药有限公司 2-((1s,2s,3r,6s,8s)-2-(氨甲基)三环[4.2.1.03,8]壬烷-2-基)乙酸苯磺酸盐或其组合物杂质检测方法
CN110590529A (zh) * 2019-09-25 2019-12-20 浙江医药高等专科学校 一种1-芳基-2-丙酮类化合物的制备方法

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DE69709070T2 (de) * 1996-03-14 2002-06-20 Warner Lambert Co Verbrückte zyklische aminosäuren als pharmazeutische mittel
GEP20094817B (en) * 1997-10-27 2009-11-10 Warner Lambert Co Cyclic amino acids and derivatives thereof useful as pharmaceutical agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7868043B2 (en) 2008-01-25 2011-01-11 Xenoport, Inc. Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use
US7872046B2 (en) 2008-01-25 2011-01-18 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
US8062870B2 (en) 2008-01-25 2011-11-22 Xenoport, Inc. Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs
US8258179B2 (en) 2008-01-25 2012-09-04 Xenoport, Inc. Crystalline form of a (3S)-aminomethyl-5-methyl-hexanoic acid prodrug and methods of use
WO2014113299A1 (en) 2013-01-15 2014-07-24 Warsaw Orthopedic, Inc. Clonidine compounds in a biodegradable fiber
US10654794B2 (en) 2016-09-14 2020-05-19 Sichuan Haiso Pharmaceutical Co., Ltd. Fused tricyclic Γ-amino acid derivative, preparation method therefor, and medical use thereof

Also Published As

Publication number Publication date
DOP2002000372A (es) 2002-10-30
CN100354251C (zh) 2007-12-12
ZA200307097B (en) 2004-09-13
GB0109635D0 (en) 2001-06-13
ECSP034804A (es) 2003-12-01
CN1720219A (zh) 2006-01-11
UA74879C2 (en) 2006-02-15
GT200200074A (es) 2002-12-24

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