GB2220206B - Carboxamide compounds,processes for preparing the same and a pharmaceutical composition containing the same - Google Patents
Carboxamide compounds,processes for preparing the same and a pharmaceutical composition containing the sameInfo
- Publication number
- GB2220206B GB2220206B GB8914891A GB8914891A GB2220206B GB 2220206 B GB2220206 B GB 2220206B GB 8914891 A GB8914891 A GB 8914891A GB 8914891 A GB8914891 A GB 8914891A GB 2220206 B GB2220206 B GB 2220206B
- Authority
- GB
- United Kingdom
- Prior art keywords
- same
- preparing
- processes
- pharmaceutical composition
- composition containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/62—Isoquinoline or hydrogenated isoquinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/650947—Six-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
- C07F9/65335—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6544—Six-membered rings
- C07F9/6547—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16308288 | 1988-06-29 | ||
| JP15278489 | 1989-06-15 | ||
| JP1160171A JPH0745508B2 (ja) | 1988-06-29 | 1989-06-21 | カルボン酸アミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8914891D0 GB8914891D0 (en) | 1989-08-23 |
| GB2220206A GB2220206A (en) | 1990-01-04 |
| GB2220206B true GB2220206B (en) | 1992-05-20 |
Family
ID=27320347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8914891A Expired - Lifetime GB2220206B (en) | 1988-06-29 | 1989-06-29 | Carboxamide compounds,processes for preparing the same and a pharmaceutical composition containing the same |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4971957A (https=) |
| AU (1) | AU606808B2 (https=) |
| CA (1) | CA1339370C (https=) |
| CH (1) | CH678530A5 (https=) |
| DE (1) | DE3921188C2 (https=) |
| ES (1) | ES2017820A6 (https=) |
| FR (1) | FR2633624B1 (https=) |
| GB (1) | GB2220206B (https=) |
| IT (1) | IT1235532B (https=) |
| NL (1) | NL194239C (https=) |
| SE (1) | SE469895B (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945109A (en) * | 1988-08-24 | 1990-07-31 | Buckman Laboratories International, Inc. | Ester of carbamic acid useful as a microbicide and a preservative |
| EP0524146A1 (de) * | 1991-07-19 | 1993-01-20 | Ciba-Geigy Ag | Aminosubstituierte Piperazinderivate |
| US5384319A (en) * | 1993-01-06 | 1995-01-24 | Ciba-Geigy Corporation | Aminoalkylphenyl compounds |
| US5380726A (en) * | 1993-01-15 | 1995-01-10 | Ciba-Geigy Corporation | Substituted dialkylthio ethers |
| TW260664B (https=) * | 1993-02-15 | 1995-10-21 | Otsuka Pharma Factory Inc | |
| WO1995000524A1 (fr) * | 1993-06-17 | 1995-01-05 | Otsuka Pharmaceutical Factory, Inc. | Derive de diester phosphonique |
| JP3074332B2 (ja) * | 1993-08-20 | 2000-08-07 | 株式会社大塚製薬工場 | ホスホン酸ジエステル誘導体 |
| WO1997012903A1 (en) * | 1995-10-04 | 1997-04-10 | Warner-Lambert Company | Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins |
| DE69624143T2 (de) * | 1995-12-27 | 2003-06-12 | Otsuka Pharmaceutical Factory, Inc. | Phosphonsaurediester-derivate |
| US6495032B2 (en) | 1999-05-19 | 2002-12-17 | Dynetek Industries Ltd. | Filter arrangement |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| CN1486302A (zh) * | 2000-12-07 | 2004-03-31 | CV���ƹ�˾ | 作为抗冠状动脉疾病或动脉硬化的abca-1加强化合物的取代1,3,5-三嗪和嘧啶 |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7569725B2 (en) | 2004-10-21 | 2009-08-04 | Britsol-Myers Squibb Company | Anthranilic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
| CA2592118C (en) | 2004-12-23 | 2015-11-17 | Deciphera Pharmaceuticals, Llc | Urea derivatives as enzyme modulators |
| EP2049124A4 (en) * | 2006-07-20 | 2010-02-10 | Merck & Co Inc | PHOSPHOR DERIVATIVES AS HISTONDEACETYLASE HEMMER |
| US8188113B2 (en) | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| CN101595092B (zh) | 2006-11-02 | 2012-02-01 | 米伦纽姆医药公司 | 合成因子xa抑制剂的医药盐的方法 |
| WO2008131276A1 (en) | 2007-04-20 | 2008-10-30 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| JP5444365B2 (ja) | 2008-10-29 | 2014-03-19 | デシフェラ ファーマシューティカルズ，エルエルシー | 抗癌活性および抗増殖活性を示すシクロプロパンアミドおよび類似物質 |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| IL276398B2 (en) | 2018-01-31 | 2026-03-01 | Deciphera Pharmaceuticals Llc | Combination therapy for mastocytosis |
| CN118416236A (zh) | 2018-01-31 | 2024-08-02 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| WO2020185812A1 (en) | 2019-03-11 | 2020-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| EP4013412B1 (en) | 2019-08-12 | 2026-01-28 | Deciphera Pharmaceuticals, LLC | Ripretinib for treating gastrointestinal stromal tumors |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| MX2022008103A (es) | 2019-12-30 | 2022-09-19 | Deciphera Pharmaceuticals Llc | Formulaciones de inhibidores de la cinasa amorfa y metodos de estas. |
| EP4084779B1 (en) | 2019-12-30 | 2024-10-09 | Deciphera Pharmaceuticals, LLC | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0273444A2 (en) * | 1986-12-29 | 1988-07-06 | Otsuka Pharmaceutical Factory, Inc. | Use of carboxamide compounds for the preparation of a medicament for treating hyperlipidemia |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61151199A (ja) * | 1984-12-26 | 1986-07-09 | Otsuka Pharmaceut Factory Inc | カルボン酸アミド誘導体 |
| CA1274919A (en) * | 1985-07-27 | 1990-10-02 | Akio Ohba | Method of forming curved surfaces and the apparatus |
| US4822780A (en) * | 1987-07-08 | 1989-04-18 | Otsuka Pharmaceutical Factory, Inc. | Carboxamide compounds |
-
1989
- 1989-06-27 AU AU37078/89A patent/AU606808B2/en not_active Ceased
- 1989-06-28 IT IT8967528A patent/IT1235532B/it active
- 1989-06-28 DE DE3921188A patent/DE3921188C2/de not_active Expired - Fee Related
- 1989-06-28 CA CA000604124A patent/CA1339370C/en not_active Expired - Fee Related
- 1989-06-28 SE SE8902326A patent/SE469895B/sv not_active IP Right Cessation
- 1989-06-29 FR FR8908722A patent/FR2633624B1/fr not_active Expired - Fee Related
- 1989-06-29 GB GB8914891A patent/GB2220206B/en not_active Expired - Lifetime
- 1989-06-29 US US07/373,837 patent/US4971957A/en not_active Expired - Lifetime
- 1989-06-29 ES ES8902301A patent/ES2017820A6/es not_active Expired - Lifetime
- 1989-06-29 CH CH2429/89A patent/CH678530A5/de not_active IP Right Cessation
- 1989-06-29 NL NL8901652A patent/NL194239C/nl not_active IP Right Cessation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0273444A2 (en) * | 1986-12-29 | 1988-07-06 | Otsuka Pharmaceutical Factory, Inc. | Use of carboxamide compounds for the preparation of a medicament for treating hyperlipidemia |
Non-Patent Citations (1)
| Title |
|---|
| JP 61/15119 (Otsuka) (see CA 106: 67489s) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1339370C (en) | 1997-08-26 |
| DE3921188A1 (de) | 1990-01-18 |
| NL8901652A (nl) | 1990-01-16 |
| AU3707889A (en) | 1990-01-04 |
| CH678530A5 (https=) | 1991-09-30 |
| NL194239C (nl) | 2001-10-02 |
| SE469895B (sv) | 1993-10-04 |
| SE8902326L (sv) | 1989-12-30 |
| GB8914891D0 (en) | 1989-08-23 |
| FR2633624B1 (fr) | 1996-07-05 |
| US4971957A (en) | 1990-11-20 |
| DE3921188C2 (de) | 1997-08-14 |
| ES2017820A6 (es) | 1991-03-01 |
| IT8967528A0 (it) | 1989-06-28 |
| FR2633624A1 (fr) | 1990-01-05 |
| AU606808B2 (en) | 1991-02-14 |
| IT1235532B (it) | 1992-09-09 |
| SE8902326D0 (sv) | 1989-06-28 |
| GB2220206A (en) | 1990-01-04 |
| NL194239B (nl) | 2001-06-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2220206B (en) | Carboxamide compounds,processes for preparing the same and a pharmaceutical composition containing the same | |
| ZA904997B (en) | Heteroarylamino-and heteroaryloxypridinamines and related compounds,a process for their preparation and their use as medicaments | |
| ZA89958B (en) | Pharmaceutical compositions containing lactams,new substituted lactams and processes for the preparation thereof | |
| IL92425A0 (en) | Alpha-d-glucofuranose derivatives,pharmaceutical compositions containing the same and processes for the preparation thereof | |
| ZA895838B (en) | Pharmaceutical compounds | |
| GB8924286D0 (en) | Pharmaceutical composition and process for preparing the same | |
| IL88903A (en) | Indolylpiperidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same | |
| IL95548A0 (en) | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same | |
| IL86027A (en) | 2-acylpyrrolidine derivatives,a process for the preparation thereof,compositions containing them,and their use | |
| ZA897541B (en) | Benzoxazolinone derivatives,process for the preparation thereof and pharmaceutical compositions containing them | |
| IL87563A (en) | Isoxazole-b-carboline derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same | |
| PH25102A (en) | Pharmaceutical compounds | |
| IL91675A0 (en) | Cyclic compounds,pharmaceutical compositions containing the same and processes for the preparation thereof | |
| IL86173A (en) | Pyrrolidine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same | |
| EP0430025A3 (en) | Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same | |
| ZA897228B (en) | Pharmaceuticals containing 2,7-diamino-1,2,3,4-tetrahydronaphthalines,new compounds and manufacture | |
| ZA893037B (en) | Medicaments containing 1,2-dithiol-3-thion-s-oxide compounds | |
| IL96782A0 (en) | Aminopyridinylmethanols and aminomethylpyridinamines and related compounds,a process for their preparation and their use as medicaments | |
| IL106433A0 (en) | Furylthiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same | |
| IL90219A0 (en) | Hydrazinocarbonyloxylabdanes,a process for their preparation and pharmaceutical compositions containing them | |
| IL94894A0 (en) | Phenoxypyridinamines and related compounds,a process for their preparation and their use as medicaments | |
| ZA8999B (en) | New indolylpieridine compounds,processes for the preparation thereof and pharmaceutical composition comprising the same | |
| IL85162A0 (en) | 3-methylenespiro(benzofuranpiperidines),a process for the preparation thereof,and pharmaceutical compositions containing them | |
| ZA897050B (en) | 2,3,4,5-tetrahydro-1-benzoxepins,a process for the preparation thereof,the use thereof and pharmaceutical products based on these compounds | |
| ZA903603B (en) | New arylsulphonamides,pharmaceutical compositions containing these compounds and processes for preparing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 20080629 |