GB2165249A - Preparation of mitomycin derivatives - Google Patents

Preparation of mitomycin derivatives Download PDF

Info

Publication number
GB2165249A
GB2165249A GB08524725A GB8524725A GB2165249A GB 2165249 A GB2165249 A GB 2165249A GB 08524725 A GB08524725 A GB 08524725A GB 8524725 A GB8524725 A GB 8524725A GB 2165249 A GB2165249 A GB 2165249A
Authority
GB
United Kingdom
Prior art keywords
mitomycin
electrophile
amino
methoxymitosane
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB08524725A
Other languages
English (en)
Other versions
GB8524725D0 (en
Inventor
Henry She Lai Wong
Takushi Kaneko
Terrence William Doyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB8524725D0 publication Critical patent/GB8524725D0/en
Publication of GB2165249A publication Critical patent/GB2165249A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB08524725A 1984-10-09 1985-10-08 Preparation of mitomycin derivatives Withdrawn GB2165249A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65912884A 1984-10-09 1984-10-09

Publications (2)

Publication Number Publication Date
GB8524725D0 GB8524725D0 (en) 1985-11-13
GB2165249A true GB2165249A (en) 1986-04-09

Family

ID=24644154

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08524725A Withdrawn GB2165249A (en) 1984-10-09 1985-10-08 Preparation of mitomycin derivatives

Country Status (7)

Country Link
JP (1) JPS6191189A (it)
DK (1) DK460285A (it)
FR (1) FR2571373A1 (it)
GB (1) GB2165249A (it)
HU (1) HUT38943A (it)
IT (1) IT1187749B (it)
SE (1) SE8504659L (it)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0265050A1 (en) * 1986-08-26 1988-04-27 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
EP0294828A2 (en) * 1987-06-12 1988-12-14 Bristol-Myers Squibb Company Mitomycin analogs, a process for preparing them and pharmaceutical compositions

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3871836T2 (de) * 1987-03-25 1993-01-14 Kyowa Hakko Kogyo Kk Mitomycin-derivate.

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2106096A (en) * 1981-05-15 1983-04-07 University Patents Inc Mitomycin derivatives their preparation and use
GB2151627A (en) * 1983-12-23 1985-07-24 Bristol Myers Co 7-acylamino mitosanes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2106096A (en) * 1981-05-15 1983-04-07 University Patents Inc Mitomycin derivatives their preparation and use
GB2151627A (en) * 1983-12-23 1985-07-24 Bristol Myers Co 7-acylamino mitosanes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY 26 (1) 16-20 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0265050A1 (en) * 1986-08-26 1988-04-27 Kyowa Hakko Kogyo Kabushiki Kaisha Mitomycin derivatives
EP0294828A2 (en) * 1987-06-12 1988-12-14 Bristol-Myers Squibb Company Mitomycin analogs, a process for preparing them and pharmaceutical compositions
EP0294828A3 (en) * 1987-06-12 1990-05-09 Bristol-Myers Squibb Company Mitomycin analogs, a process for preparing them and pharmaceutical compositions
US5374739A (en) * 1987-06-12 1994-12-20 Bristol-Myers Squibb Company Mitomycin analogs

Also Published As

Publication number Publication date
SE8504659D0 (sv) 1985-10-08
GB8524725D0 (en) 1985-11-13
DK460285D0 (da) 1985-10-08
DK460285A (da) 1986-04-10
JPS6191189A (ja) 1986-05-09
IT8522385A0 (it) 1985-10-08
SE8504659L (sv) 1986-04-10
HUT38943A (en) 1986-07-28
IT1187749B (it) 1987-12-23
FR2571373A1 (fr) 1986-04-11

Similar Documents

Publication Publication Date Title
PT2989106T (pt) Compostos heterocíclicos fundidos como inibidores da proteína quinase
HUE035116T2 (hu) PI3K inhibitor pirimidinszármazékok és alkalmazásuk
US4866180A (en) Amino disulfide thiol exchange products
WO2020156437A1 (zh) Akt抑制剂
US5663339A (en) Process for preparing 5-substituted pyrrolo-[2,3-D] pyrimidines
CN115427044A (zh) 作为补体抑制剂的吡咯并嘧啶胺
NO314404B1 (no) Pyrrolopyrazolopyrimidin-forbindelser og medisin omfattende denne og fremgangsmåte for fremstilling derav
Peterson et al. Synthesis and biological evaluation of carbocyclic analogs of lyxofuranosides of 2-amino-6-substituted purines and 2-amino-6-substituted-8-azapurines
Komkov et al. Synthesis of new pyrido [2, 3-d] pyrimidin-5-one, pyrido [2, 3-d] pyrimidin-7-one, and pyrimidino [4, 5-d][1, 3] oxazine derivatives from 5-acetyl-4-aminopyrimidines
CN116528871A (zh) 一种吡唑并喹唑啉类化合物、其制备方法及应用
CA1285567C (en) Disulfide derivatives of pyrroloindole
DK169477B1 (da) Acylaminomitosaner og fremgangsmåde til fremstilling deraf
GB2165249A (en) Preparation of mitomycin derivatives
US4814445A (en) Process for preparing mitomycin analogs
CA1291293C (en) Substituted 7-oxomitosanes
WO2021228223A1 (zh) 氘代akt激酶抑制剂
Schroeder et al. Synthesis and biological evaluation of 6-ethynyluracil, a thiol-specific alkylating pyrimidine
US4652644A (en) Process for preparation of N7 -amidino substituted mitomycin C derivatives
Sirakanyan et al. Synthesis and antimicrobial evaluation of novel polyheterocyclic systems derived from cyclopenta [4', 5'] pyrido [3', 2': 4, 5] furo [3, 2-d] pyrimidine
US4623725A (en) [1,2,4]Triazolo[4,3-a]quinoxaline-4-amine derivatives
US4691023A (en) Amino disulfides
US4927943A (en) Substituted 7-oxomitosanes
US4547501A (en) Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents
US5374739A (en) Mitomycin analogs
AU595183B2 (en) Crystalline form of 7-(dimethylaminomethylene) amino-9a- methoxymitosane

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)