GB2164624A - Process for preparing liposome compositions - Google Patents

Process for preparing liposome compositions Download PDF

Info

Publication number
GB2164624A
GB2164624A GB08523309A GB8523309A GB2164624A GB 2164624 A GB2164624 A GB 2164624A GB 08523309 A GB08523309 A GB 08523309A GB 8523309 A GB8523309 A GB 8523309A GB 2164624 A GB2164624 A GB 2164624A
Authority
GB
United Kingdom
Prior art keywords
vesicles
aqueous medium
freeze
cation
divalent cation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB08523309A
Other languages
English (en)
Other versions
GB8523309D0 (en
Inventor
Hiroaki Jizomoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of GB8523309D0 publication Critical patent/GB8523309D0/en
Publication of GB2164624A publication Critical patent/GB2164624A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB08523309A 1984-09-21 1985-09-20 Process for preparing liposome compositions Withdrawn GB2164624A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59199011A JPS6176414A (ja) 1984-09-21 1984-09-21 リポソーム製剤の製法

Publications (2)

Publication Number Publication Date
GB8523309D0 GB8523309D0 (en) 1985-10-23
GB2164624A true GB2164624A (en) 1986-03-26

Family

ID=16400622

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08523309A Withdrawn GB2164624A (en) 1984-09-21 1985-09-20 Process for preparing liposome compositions

Country Status (4)

Country Link
US (1) US4762720A (enExample)
EP (1) EP0179237A1 (enExample)
JP (1) JPS6176414A (enExample)
GB (1) GB2164624A (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007852A1 (en) * 1987-04-06 1988-10-20 Innovative Therapeutics Corporation Liposome entrapped magnesium
WO1995009610A1 (en) * 1993-10-07 1995-04-13 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Liposomes containing particulate materials
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
WO2003000232A3 (en) * 2001-06-25 2004-02-26 Yissum Res Dev Co Method for preparation of vesicles loaded with immunostimulator y oligodeoxynucleotides
US7381421B2 (en) * 1999-12-13 2008-06-03 Lipoxen Technologies Limited Liposomes

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090406A (en) * 1984-04-12 2000-07-18 The Liposome Company, Inc. Potentiation of immune responses with liposomal adjuvants
US5916588A (en) * 1984-04-12 1999-06-29 The Liposome Company, Inc. Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
US5171578A (en) * 1985-06-26 1992-12-15 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US4885172A (en) * 1985-06-26 1989-12-05 The Liposome Company, Inc. Composition for targeting, storing and loading of liposomes
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
US5252263A (en) * 1986-06-16 1993-10-12 The Liposome Company, Inc. Induction of asymmetry in vesicles
JP2660341B2 (ja) * 1986-12-04 1997-10-08 武田薬品工業株式会社 リポソーム製剤およびその製造法
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
ATE84221T1 (de) * 1987-12-03 1993-01-15 Liposome Co Inc Arzneimittel mit methylcellulose.
EP0389570B2 (en) * 1987-12-04 2000-07-19 The Liposome Company, Inc. High integrity liposomes and method of preration and use
CA1330199C (en) * 1987-12-22 1994-06-14 Thomas D. Madden Spontaneous vesiculation of multilamellar liposomes
US4921644A (en) * 1988-02-29 1990-05-01 Technology Unlimited, Inc. Mucin directed lipsome
FR2638639A1 (fr) * 1988-11-08 1990-05-11 Parincos Parfumerie Cosmet Int Composition et procede d'obtention de liposomes oligolamellaires en vue d'une application en cosmetologie et dermatologie topique
DE69025934T2 (de) * 1989-05-17 1996-09-19 Res Corp Technologies Inc Verfahren und zusammensetzung zur thrombosebehandlung beim säugetier
US5227170A (en) * 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
CA2059129C (en) * 1989-06-22 1996-07-02 Sean M. Sullivan Encapsulation process
US5290563A (en) * 1989-07-27 1994-03-01 Laboratoire Des Stallergenes Method for combining a mixture of heterogeneous substances with liposomes
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
FR2677248B1 (fr) * 1991-06-04 1995-06-16 Lvmh Rech Gie Composition cosmetique ou pharmaceutique, notamment dermatologique, contenant un extrait de brunelle.
US5665381A (en) * 1992-02-25 1997-09-09 Nexstar Pharmaceuticals, Inc. Inhibition of aggregation of drug containing particles
WO1994012155A1 (en) * 1992-12-02 1994-06-09 Vestar, Inc. Antibiotic formulation and process
US5958449A (en) * 1992-12-02 1999-09-28 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for bacterial infections
US5759571A (en) * 1993-05-11 1998-06-02 Nexstar Pharmaceuticals, Inc. Antibiotic formulation and use for drug resistant infections
US5501859A (en) * 1994-03-22 1996-03-26 Walter T. Woods, Jr. Absorbable magnesium composition and method of using same
US5756122A (en) * 1995-06-07 1998-05-26 Georgetown University Liposomally encapsulated nucleic acids having high entrapment efficiencies, method of manufacturer and use thereof for transfection of targeted cells
JP5038552B2 (ja) * 1995-10-17 2012-10-03 オバン・エナジー・リミテッド 不溶性薬物の送達
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
JP2001519823A (ja) * 1997-04-11 2001-10-23 ヴィレックス バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング ウロキナーゼレセプターの抑制剤
DE69908304T2 (de) * 1998-02-11 2004-02-19 Rtp Pharma Corp. Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
AU764001B2 (en) 1998-05-29 2003-08-07 Skyepharma Canada Inc. Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
AU759641B2 (en) 1998-08-19 2003-04-17 Skyepharma Canada Inc. Injectable aqueous dispersions of propofol
HUP0105089A3 (en) 1998-11-20 2002-09-30 Skyepharma Canada Inc Compositions containing the active ingredient in form dispersible phospholipid stabilized microparticles
ATE296091T1 (de) * 1999-09-21 2005-06-15 Skyepharma Canada Inc Oberflächenmodifizierte teilchenförmige zusammensetzungen biologisch aktiver stoffe
ES2469642T3 (es) 2000-04-20 2014-06-18 Jagotec Ag Procedimiento mejorado para partículas de fármaco insoluble en agua
US20030124180A1 (en) * 2000-05-02 2003-07-03 Jurgen Ebert Liposomes containing active substances
WO2002017883A2 (en) 2000-08-31 2002-03-07 Rtp Pharma Inc. Milled particles
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
NZ527408A (en) * 2001-02-22 2005-04-29 Skyepharma Canada Inc Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia
DE60237162D1 (de) * 2001-10-03 2010-09-09 Celator Pharmaceuticals Inc Liposomenladung mit metallionen
US20040018237A1 (en) * 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
FI120642B (fi) 2007-10-19 2010-01-15 Biomed Oy Mikrokapseloidut liposomikoostumukset
US20100260830A1 (en) * 2009-04-08 2010-10-14 Brian A Salvatore Liposomal Formulations of Tocopheryl Amides
EP3043781A1 (en) 2013-09-13 2016-07-20 Arbor Therapeutics, LLC Nanoparticulate compositions for targeted delivery of lipophilic drugs and acid labile, lipophilic prodrugs of cancer chemotherapeutics and their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078052A (en) * 1976-06-30 1978-03-07 The United States Of America As Represented By The Secretary Of Health, Education And Welfare Large unilamellar vesicles (LUV) and method of preparing same
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988007852A1 (en) * 1987-04-06 1988-10-20 Innovative Therapeutics Corporation Liposome entrapped magnesium
WO1995009610A1 (en) * 1993-10-07 1995-04-13 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Liposomes containing particulate materials
GB2297907A (en) * 1993-10-07 1996-08-21 Secr Defence Liposomes containing particulate materials
GB2297907B (en) * 1993-10-07 1997-12-10 Secr Defence Liposomes containing particulate materials
RU2145212C1 (ru) * 1993-10-07 2000-02-10 Министр обороны Объединенного королевства Великобритании и Северной Ирландии Липосомы, содержащие материалы, состоящие из частиц
US6322809B1 (en) 1993-10-07 2001-11-27 The Secretary Of State For Defence In Her Brittanic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Liposomes containing particulate materials
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US7381421B2 (en) * 1999-12-13 2008-06-03 Lipoxen Technologies Limited Liposomes
WO2003000232A3 (en) * 2001-06-25 2004-02-26 Yissum Res Dev Co Method for preparation of vesicles loaded with immunostimulator y oligodeoxynucleotides

Also Published As

Publication number Publication date
EP0179237A1 (en) 1986-04-30
GB8523309D0 (en) 1985-10-23
JPH0468284B2 (enExample) 1992-11-02
US4762720A (en) 1988-08-09
JPS6176414A (ja) 1986-04-18

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)