GB2156783A - Dosage device - Google Patents
Dosage device Download PDFInfo
- Publication number
- GB2156783A GB2156783A GB08506731A GB8506731A GB2156783A GB 2156783 A GB2156783 A GB 2156783A GB 08506731 A GB08506731 A GB 08506731A GB 8506731 A GB8506731 A GB 8506731A GB 2156783 A GB2156783 A GB 2156783A
- Authority
- GB
- United Kingdom
- Prior art keywords
- unit
- storage chamber
- dosing
- dosing unit
- recesses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
- G01F11/12—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements
- G01F11/20—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber rotates or oscillates
- G01F11/24—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber rotates or oscillates for fluent solid material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
- G01F11/26—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus
- G01F11/261—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus for fluent solid material
Landscapes
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- General Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Health & Medical Sciences (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
- Basic Packing Technique (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
- Filling Or Emptying Of Bunkers, Hoppers, And Tanks (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
Abstract
A dosage device for dosing with high accuracy a particulate material containing a pharmacalogically active substance, including a storage chamber (4), a rotatable dosing unit (2) adjacent the storage chamber, an operating unit (1) to cause relative rotation between the dosing unit and the storage chamber, the dosing unit (2) being provided with a plurality of upwardly opening recesses (7) opening into said storage chamber (4), to receive particulate material therefrom. Scrapers (8) are positioned immediately above these recesses to pack and level the particulate material into the recesses (7) and level the material off with the upper surfaces of the recesses as the dosing unit rotates relative to the storage chamber (4) The operating unit (1) causes an indexing of the dosing unit (2) between discrete rotational positions in one of which one of the recesses (7) is in direct communication with a generally 9 upwardly extending dispensing channel (5) so that when the unit is turned upside down that recess will discharge through the channel (5). <IMAGE>
Description
SPECIFICATION
Dosage device
The present invention relates to a new dosage device intended to be used for dosing of micronized or granulated substances or microcapsules (hereinafter referred to collectively as particulate material) and containing pharmacologically active substances.
Several preparations of drugs are nowadays administered in micronized or granulated form or in the form of microcapsules. These substances are filled into capsules of hard gelatine, which are intended for oral administration and are swallowed whole by the patient. Children and adults who have difficulties in swallowing a whole capsule are recommended to open the capsule and spread the contents on a suitable piece of food and to swallow. It is, however, difficult to open the capsule and pour out the contents without any loss of the substance. Capsules of hard gelatine are an expensive, but effective, way to administer pharmacologically active substances to patients, who are able to swallow the capsules unbroken.It is, however, not sensible to use this expensive way of dispensing into capsules of hard gelatine, when the latient later on, with some difficulty, opens the capsule and pours out the contents.
It has previously been proposed to provide dosage devices to enable the particulate material to be dispensed accurately. For example DE-A-2 052 051 describes a dosage device comprising a control unit and a storage chamber. The control unit is fitted relatively loosely to the casing of the device. Substances having small particles thus easily fall on the sliding surfaces between the two relatively movable units, so that substance being fed jams. With such a dosage device, it is difficult to dose small amounts of micronized or granulated substances with an accuracy which is sufficient for the dispensing of drugs.
According to the present invention there is provided a dosage device for dosing with high accuracy a particulate material containing a pharmacalogically active substance, said device comprising a storage chamber, a rotatable dosing unit adjacent said storage chamber, an operating unit to cause relative rotation between said dosing unit and said storage chamber, a plurality of upwardly opening recesses in said dosing unit, at least one of which opens into said storage chamber, to receive particulate material therefrom, scrapers positioned to pack and level the particulate material into the recesses and level it off with the upper surface of the dosing unit as the dosing unit rotates relative to the storage chamber, operating means on said operating unit for causing indexing of the dosing unit between discrete rotational positions, and a generally upwardly extending dispensing channel positioned at one of said discrete positions to communicate with one of said recesses, so that said one recess may be emptied by turning said device upside down.
With the construction according to the present invention, the substance is prevented from getting into contact with the sliding surfaces in the two relatively movable parts of the dosage device and in this way feeding of each dose can be achieved without any problems. In the dosage device according to the invention, the scrapers make it possible to fill the recesses in the dosing unit in a accurately reproducable way. A high dosage accuracy can thus be obtained by the rotation of the dosing unit.
In order that the invention may more readily be understood, the following description is given, merely by way of example, reference being made to the accompanying drawing, in which: Figure 1 is an axial cross-section of one embodiment of dosage device according to the invention; and
Figure 2 is a cross-section taken along the line ll-ll of Fig. 1.
The dosage unit of the present invention can be considered to comprise four separate units as follows: an operating unit 1 at the bottom of the dosage device;
a spring loaded dispensing unit 2;
a scraping unit 3; and
a storage chamber 4 provided with a dispensing channel 5 for the dose to be dispensed.
A further separate part is shown in the drawings and is preferred, but is not essential, this being in the form of a plastic or metal hood 6 which can be retained by a peripheral rib (not shown) at the upper part of the operating unit 1. This rib enables the hood to be removably retained. An alternative way of sealing the device is to provide a plug in the top of the dispensing channel 5.
At the lower mid part of the storage chamber 4, the scraping unit 3 is fixed to the inner wall of the storage chamber so that it cannot rotate relative thereto. The scraping unit in fact includes the lower part of the dispensing channel 5 which is formed integrally with the storage chamber 4. From Fig. 2 it will be seen more clearly that the scraping unit 3 includes 5 radially extending arms each of which carries a resilient scraper 8 in sliding contact with the upper surface of the dosing unit 2 which, in turn, is provided with six circumferentilly spaced slightly frustoconical recesses 7 positioned immediately under the scrapers 8.In order to guide for rotation the dosing unit 2, the scraping unit has an outer peripheral skirt engaging the cylindrical outer surface of the dosing unit 2 and a short inner annulus engaging the upper surface of the dosing unit inwardly of the recesses 7 in order to prevent jamming at feeding. The dosing unit 2 is loaded by a spring 9 in order to press the dosing unit against the scraping unit.Between the dispensing unit and the spring there is situated a disc 14 which is keyed to the dosing unit and has a toothed ring 1 3. The operating unit 1, against which the other end of the spring 9 abuts, caries a resilient arm 1 2 which is engageable with the toothed ring 1 3. Thus the disc 14, in effect, controls the angular movement of the dosing unit 2 so that one of the recesses 7 will always stop in the correct position that is immediately below the dispensing channel 5 as shown in Fig. 1. Furthermore, the disc 14 reduces the friction between the spring and the dosing unit.
In the operating unit 1 there is provided a space 10, as illustrated closed by a porous pad and into the space 10 can be inserted a drying agent such as silica gel in order to protect the contents of the device from the humidity of the air. The ingress of humidity will also be reduced by the provision of the hood 6.
The particulate pharmaceutically active substance is stored inside the storage chamber 4 and the actual dosing operation is carried out with the dosing device in the upright position shown in Fig. 1, by rotating the operating unit at first counterclockwise and then clockwise. The ratchet mechanism formed by the roothed ring 1 3 and the resilient arm 1 2 will thus index the dosing unit so that first one and then another recess appear immediately under the dispensing channel.
All of the recesses, however open into the storage chamber and can be filled with the particulate material therein. Thus, a predetermined amount of particulate pharmaceutically active substance can be dosed by the correct choice of the size of the recess 7. The effect of the scrapers 8 on the scrapng unit 3, past which the dosing unit recesses move, is firstly to force and pack the particulate material into the recess and secondly accurately to level off the particulate material at the top of the recess. This means that when a recess 7 arrives immediately below the dispensing channel 5 it will be completely and acurately full.
All that is then necessary is to turn the dosage device upside down and the particulate material will flow down the dispensing channel 5. By choosing the size of the recess for which ever substance is to be dispensed, one can thus choose the size of a dose which may, for example be caried within wide limits, say from 1 to 5 mg or 5 to 200 mg. The number of recesses in the dosing unit may vary depending on different factors, such as the amount of active substance which should be administered in each dose, the physical properties of the active substances so on. In a preferred embodiment, the dosing unit has six recesses and these recesses are preferably cylindrical or preferably frustoconical as shown and should preferably hold 1 dose of ative substance.
The size of the storage chamber may be chosen to suit the requirements expected for a particular active substance. In a dosage device where the storage chamber cannot be refilled with active substance, the chamber may, for example, contains sufficient active substance for about 100 doses.
In an alternative embodiment the dosage device has a resilient key whch makes it possible to feed the device with one hand. Each push on the key causes indexing of the dosing device so that a recess filled with the active substance is placed in communication with the dispensing channel.
The dosage device may be used as container and aid in dispensing of a great number of active substances such as enprophylline, theophylline and terbutaline.
Example
In order to demostrate the dosage accuracy of the dosage device according to the present invention the following tests have been carried out with different sizes of the recesses 7. The container was filled with Theo-Dur sprinkle substance (which is a slow release preparation of theophylline) mixed with 1 and 2% of talcum respectively. When the dosage accuracy of 500 doses was established a maximum deviation of 3.5% was obtained. Cf. the table below.
Test with seven different dosage devices containing Theo-Dur sprinkle substance mixed with talcum.
The figures below are the average values of 500 doses from each dosage device.
Dosage Talcum device 1% 2% 1 104,1 2.15 2.1 104.2 2.45 2.4 2 94.0 2.36 2.5 94.0 2.66 2.8 3 85.4 2.29 2.7 84.8 2.30 2.7 4 73,2 2.45 3.3 75.1 1.73 2.3 5 64.7 1.68 2.6 64.5 2.02 3.1 6 54.3 1.33 2.5 53.4 1.87 3.5 7 45.8 1.34 2.9 45.9 1.30 2.8
As a comparison reference is made to Pharm. Nord, which specifies that 90% of the capsules shall have a weight which does not deviate more than 10% from the stipulated weight. The rest shall not deviate more than 20%. With the new dosage device according to the invention these requirements are thus met with an ample margin.
Claims (11)
1. A dosage device for dosing with high accuracy a particulate material containing a pharmacalogically active substance, said device comprising a storage chamber, a rotatable dosing unit adjacent said storage chamber, an operating unit to cause relative rotation between said dosing unit and said storage chamber, a plurality of upwardly opening recesses in said dosing unit, at least one of which opens into said storage chamber, to receive particulate material therefrom, scrapers positioned to pack and level the particulate material into the recesses and level it off with the upper surfaces of the recesses as the dosing unit rotates relative to the storage chamber, operating means on said operating unit for causing indexing of the dosing unit between discrete rotational positions, and a generally upwardly extending dispensing channel positioned at one of said discrete positions to communicate with one of said recesses, so that said one recess may be emptied by turning said device upside down.
2. A device according to claim 1 wherein the operating unit is itself rotatable relative to the storage chamber to effect indexing of the dosing unit.
3. A device according to claim 2, wherein the operating unit can be rotated alternately clockwise and counterclockwise about the axis of rotation of the dosing unit and wherein said operating means comprise a ratchet mechanism between the operating unit and the dosing unit, whereby the alternate clockwise and counterclockwise rotation of the operating unit will cause indexing of the dosing unit in only one rotational sense.
4. A device according to claim 3, wherein said ratchet mechanism whereby the dosing is effected, comprises a resilient arm on the operating arm on the operating unit which engages to annularly spaced teeth on the dosing unit.
5. A device according to any preceding claim, wherein said operating unit is mounted below said dosing unit.
6. A device according to claim 5, when appendent to claim 4, wherein a disc which is keyed to the storage chamber is urged against said dosing unit by a spring engaged between said disc and said operating unit.
7. A device according to any preceding claim, wherein the dispensing channel passes through the storage chamber.
8. A device according to any preceding claim, wherein the storage channel has a closable inlet by means of which the storage chamber can be refilled.
9. A device according to any preceding claim, wherein the dosing unit is provided with six circumferentially spaced recesses.
10. A device according to any preceding claim wherein said recesses are frustoconically shaped, being wider at the open end communicating with the storage chamber.
11. A dosage unit for dosing with high accuracy a particulate material containing a pharmacalogically active substance, said device being substantially as hereinbefore described with reference to and as illustrated in, the accompanying drawings.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8401796A SE8401796D0 (en) | 1984-04-02 | 1984-04-02 | dosing device |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8506731D0 GB8506731D0 (en) | 1985-04-17 |
| GB2156783A true GB2156783A (en) | 1985-10-16 |
| GB2156783B GB2156783B (en) | 1987-08-19 |
Family
ID=20355391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08506731A Expired GB2156783B (en) | 1984-04-02 | 1985-03-15 | Dosage device |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS60225564A (en) |
| KR (1) | KR920003127B1 (en) |
| AT (1) | AT392413B (en) |
| AU (1) | AU566240B2 (en) |
| BE (1) | BE902081A (en) |
| CA (1) | CA1304327C (en) |
| CH (1) | CH668639A5 (en) |
| DE (1) | DE3511817C2 (en) |
| DK (1) | DK162208C (en) |
| ES (1) | ES541813A0 (en) |
| FI (1) | FI83032C (en) |
| FR (1) | FR2561912B1 (en) |
| GB (1) | GB2156783B (en) |
| GR (1) | GR850817B (en) |
| IE (1) | IE56449B1 (en) |
| IS (1) | IS1371B6 (en) |
| IT (1) | IT1181953B (en) |
| LU (1) | LU85828A1 (en) |
| NL (1) | NL192633C (en) |
| NO (1) | NO160129C (en) |
| NZ (1) | NZ211576A (en) |
| PT (1) | PT80205B (en) |
| SE (2) | SE8401796D0 (en) |
| ZA (1) | ZA851899B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5280846A (en) * | 1992-09-23 | 1994-01-25 | Lonnecker Bruce R | Liquid and granular fluid dispenser |
| US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| WO2018065616A1 (en) * | 2016-10-07 | 2018-04-12 | Research Center Pharmaceutical Engineering Gmbh | A system and a method for constant micro dosing and feeding of powder material |
| EP3376180B1 (en) * | 2017-03-14 | 2020-01-08 | Daneme Holding B.V. | Dispensing device for powders |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021263C2 (en) * | 1990-07-04 | 1996-04-11 | Pfeiffer Erich Gmbh & Co Kg | Discharge device for media |
| KR960704770A (en) * | 1993-09-22 | 1996-10-09 | 게이지 엘. 가아비 | Axial force indicator |
| TW533865U (en) | 1997-06-10 | 2003-05-21 | Glaxo Group Ltd | Dispenser for dispensing medicament and actuation indicating device |
| KR101020774B1 (en) | 2008-11-27 | 2011-03-09 | 주식회사 삼화플라스틱 | A Medicine Case Drawing Out Dose |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2088836A (en) * | 1936-09-24 | 1937-08-03 | Walter O Brown | Measuring container for granular material |
| US2901150A (en) * | 1954-04-26 | 1959-08-25 | Gustave O Matter | Measuring dispenser |
| DE1948180U (en) * | 1966-08-10 | 1966-10-20 | Kuma Rudolf Osterhold Kunststo | CAN WITH DOSING DEVICE FOR BREWABLE GOODS. |
| DE1956458U (en) * | 1966-12-13 | 1967-03-02 | Krups Fa Robert | HOUSEHOLD DOSING DEVICE FOR FOOD. |
| US3458091A (en) * | 1967-01-16 | 1969-07-29 | Carrol O Clement | Dispenser for powdered and granular material |
| DE2052051A1 (en) * | 1970-10-23 | 1972-04-27 | Steffens, Willi, 5208 Eitorf | Container with dosing device for free-flowing powdery to granular solids |
-
1984
- 1984-04-02 SE SE8401796A patent/SE8401796D0/en unknown
-
1985
- 1985-03-08 SE SE8501129A patent/SE459781B/en not_active IP Right Cessation
- 1985-03-13 ZA ZA851899A patent/ZA851899B/en unknown
- 1985-03-15 GB GB08506731A patent/GB2156783B/en not_active Expired
- 1985-03-19 NL NL8500799A patent/NL192633C/en not_active IP Right Cessation
- 1985-03-20 IE IE714/85A patent/IE56449B1/en not_active IP Right Cessation
- 1985-03-21 NO NO851146A patent/NO160129C/en not_active IP Right Cessation
- 1985-03-25 CH CH1323/85A patent/CH668639A5/en not_active IP Right Cessation
- 1985-03-26 AU AU40373/85A patent/AU566240B2/en not_active Expired
- 1985-03-26 NZ NZ211576A patent/NZ211576A/en unknown
- 1985-03-26 DK DK135585A patent/DK162208C/en not_active IP Right Cessation
- 1985-03-26 CA CA000477460A patent/CA1304327C/en not_active Expired - Lifetime
- 1985-03-26 IT IT47873/85A patent/IT1181953B/en active
- 1985-03-29 FR FR8504808A patent/FR2561912B1/en not_active Expired - Lifetime
- 1985-03-29 KR KR1019850002097A patent/KR920003127B1/en not_active IP Right Cessation
- 1985-03-30 DE DE3511817A patent/DE3511817C2/en not_active Expired - Lifetime
- 1985-04-01 IS IS2996A patent/IS1371B6/en unknown
- 1985-04-01 BE BE0/214757A patent/BE902081A/en not_active IP Right Cessation
- 1985-04-01 GR GR850817A patent/GR850817B/el unknown
- 1985-04-01 PT PT80205A patent/PT80205B/en unknown
- 1985-04-01 AT AT968/85A patent/AT392413B/en not_active IP Right Cessation
- 1985-04-01 ES ES541813A patent/ES541813A0/en active Granted
- 1985-04-01 JP JP60066732A patent/JPS60225564A/en active Granted
- 1985-04-01 LU LU85828A patent/LU85828A1/en unknown
- 1985-04-01 FI FI851302A patent/FI83032C/en not_active IP Right Cessation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5280846A (en) * | 1992-09-23 | 1994-01-25 | Lonnecker Bruce R | Liquid and granular fluid dispenser |
| US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| US5922354A (en) * | 1995-06-07 | 1999-07-13 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| WO2018065616A1 (en) * | 2016-10-07 | 2018-04-12 | Research Center Pharmaceutical Engineering Gmbh | A system and a method for constant micro dosing and feeding of powder material |
| US11118954B2 (en) | 2016-10-07 | 2021-09-14 | Research Center Pharmaceutical Engineering Gmbh | System and a method for constant micro-dosing and feeding of powder material |
| EP3376180B1 (en) * | 2017-03-14 | 2020-01-08 | Daneme Holding B.V. | Dispensing device for powders |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PE20 | Patent expired after termination of 20 years |
Effective date: 20050314 |