CA1304327C - Dosage device - Google Patents
Dosage deviceInfo
- Publication number
- CA1304327C CA1304327C CA000477460A CA477460A CA1304327C CA 1304327 C CA1304327 C CA 1304327C CA 000477460 A CA000477460 A CA 000477460A CA 477460 A CA477460 A CA 477460A CA 1304327 C CA1304327 C CA 1304327C
- Authority
- CA
- Canada
- Prior art keywords
- storage chamber
- dispensing unit
- recesses
- medication
- ratchet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
- G01F11/12—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements
- G01F11/20—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber rotates or oscillates
- G01F11/24—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation of the valve type, i.e. the separating being effected by fluid-tight or powder-tight movements wherein the measuring chamber rotates or oscillates for fluent solid material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
- G01F11/10—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation
- G01F11/26—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus
- G01F11/261—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers moved during operation wherein the measuring chamber is filled and emptied by tilting or inverting the supply vessel, e.g. bottle-emptying apparatus for fluent solid material
Abstract
Abstract A dosage device for dosing with high accuracy a particulate material containing a pharmacologically active substance, including a storage chamber (4), a rotatable dosing unit (2) adjacent the storage chamber, an operating unit (1) to cause relative rotation between the dosing unit and the storage chamber, the dosing unit (2) being provided with a plurality of upwardly opening recesses (7) opening into said storage chamber (4), to receive particulate material therefrom.
Scrapers (8) are positioned immediately above these recesses to pack and level the particulate material into the recesses (7) and level the material off with the upper surface of the dosing unit as the dosing unit rotates relative to the storage chamber (4).
The operating unit 51) causes an indexing of the dosing unit (2) between discrete rotational positions in one of which one of the recesses (7) is in direct communication with a generally upwardly extending dispensing channel (5) so that when the unit is turned upside down that recess will discharge through the channel (5).
Scrapers (8) are positioned immediately above these recesses to pack and level the particulate material into the recesses (7) and level the material off with the upper surface of the dosing unit as the dosing unit rotates relative to the storage chamber (4).
The operating unit 51) causes an indexing of the dosing unit (2) between discrete rotational positions in one of which one of the recesses (7) is in direct communication with a generally upwardly extending dispensing channel (5) so that when the unit is turned upside down that recess will discharge through the channel (5).
Description
The present invention relates to a new dosage device intended to be used for dosing of micronized or granulated substances or microcapsules ~hereinafter referred to collectively as particulate material) and containing pharmacologically active substances.
Several preparations of drugs are nowadays administered in micronized or granulated form or in the form of microcapsules.
These substances are filled into capsules of hard gelatine, which are intended for oral administration and are swallowed whole by the patient. Children and adults who have difficulties in swallowing a whole capsule are recommended to open the capsule and spread the contents on a suitable piece of food and to swallow.
It is, however, difficult to open the capsule and pour out the contents without any loss of the substance. Capsules of hard gelatine are an expensive, but effective, way to administer pharmacologically active substances to patients, who are able to swallow the capsules unbroken. It is, however, not sensible to use this expensive way of dispensing into capsules of hard gelatine, when the patient later on, with some difficulty, opens the capsule and pours out the contents.
It has previously been proposed to provide dosage devices to enable the particulate material to be dispensed accurately. For example DE-A-2 052 051 describes a dosage device comprising an operating unit and a storage chamber. The operating unit is fitted relatively loosely to the casing of the device.
Substances having small particles thus easily fall on the sliding C
13~4327 surfaces between the two relatively movable units, so that substance being fed jams. With such a dosage device, which does not have a feediny under force it is difficult to dose small amounts of micronized or granulated substances with an accuracy which is sufficient for the dispensing of drugs.
According to the present invention there is provided in a device for releasing a dosage of a particulate medication that includes:
a dosage dispensing unit having a face ~ith a plurality of recesses therein adapted to receive and meter a reproducible amount of said medication, a storage chamber adapted to contain the medication and having a face thereon and an outlet opening on said face which is mounted in slidable, abutting relation to the face of said dispensing unit, and a dispensing tube having a first open end through which medication can be discharged and a second open end mounted in slidable abutting relation to the face of said dispensing unit, the improvement wherein (1) said dispensing unit is mounted for rotation around an axis, and said recesses, the outlet opening of said storage chamber and the second end of said dispensing tube are all disposed in relation to said axis, such that, upon rotation of said dispensing unit, said recesses are rotated successively between operative engagement with the outlet opening of said storage chamber fox reception of medication and operative engagement with the second end of said dispensing tube for discharge of medication, (2) there is a resilient scraper located in the outlet opening of the storage chamber in sliding, resilient contact with the face of said dispensing unlt and 130~32~
configured and disposed relative to the axis of rotatlon such that it first pushes medication into the recess and then removes excess medication from above said recesses during rotation of said dispensing unit and insure that each recess contains a reproducible amount of medication, (3) said dispensing unit has ratchet means thereon arranged around the axis on which said unit rotates, (4) said device has ratchet engaging means mounted for rotation around the axis on whlch said dispensing unit rotates, said ratchet engaging means being in slidable spring-loaded contact with said ratchet means, (5) said ratchet means and ratchet engaging means are adapted to cooperate with each other such that rotation of said engaging means in one rotational direction will cause said dispensing unit to rotate in the same direction to a plurality of stations wherein at each station at least one of the recesses in said dispensing unit is in mating relation to the outlet opening in said storage chamber and another of said recesses is in mating relation to the second end of said dispensing tube and such that said engaging means will release from said ratchet means as the ratchet engaging means is rotated in the opposite rotational direction, and (6) the device has stop means coacting between the ratchet engaging means and the storage chamber for stoping the dispensing unit at each station and preventing it from advancing to the next station until the ratchet means has been released, the ratchet engaging means has been rotated in said opposite rotational direction, and the ratchet means corresponding to the next station has been engaged.
2a C
13~4327 With the construction according to the present invention, the substance is prevented from getting into contact with the sliding surfaces in the two relatively movable parts of the dosage device and in this way feeding of each dose can be achieved wlthout any problems. In the dosage device according to the invention, the scrapers make it possible to fill the recesses in the dosing unit in an accurately reproducible way. A high dosage accuracy can thus be obtained by the rotation of the dosing unit.
In order that the invention may more readily be understood, the following description is given, merely by way of example, reference being made to the accompanying drawing, in which:
Figure 1 is an axial cross-section of one embodiment of dosage device according to the invention, and Figure 2 is a cross-section taken along the line II-II of Figure 1.
The dosage device of the present invention, is preferably produced in plastic and can be considered to comprise four separate units as follows:
2b C
~3~4327 an operating unit 1 at the bottom of the dosage device;
a spring loaded dosing unit 2;
a scraping unit 3; and a storage chamber 4 provided with a dispensing channel 5 for the dose to be dispensed.
A further separate part is shown in the drawings and is preferred.
but is not essential, this being in the form of a plastic or metal hood 6 which can be retained by a peripheral rib (not shown) at the upper part of the operating unit 1. This rib enables the hood to be removably retained. An alternative way of sealing the device is to provide a plug in the top of the dispensing channel 5.
At the lower mid part of the storage chamber 4, the scraping unit 3 is fixed to the inner wall of the storage chamber so that it cannot rotate relative thereto. The scraping unit in fact includes the lower part of the dispensing channel 5 which is formed integrally with the storage chamber 4. From Figure 2 it will be seen more clearly that the scraping unit 3 includes 5 radially extending arms each of which carries a resilient scraper 8 in sliding contact with the upper surface of the dosing unit 2 which, in turn, is provided with six circumferentially spaced slightly frustoconical recesses 7 positioned immediately under the scrapers 8. In order to guide for rotation of the dosing unit 2, the scraping unit has an outer peripheral skirt engaging the cylindrical outer surface of the dosing unit 2 and a short inner annulus engaging the upper surface of the dosing unit inwardly of the recesses 7 in order to prevent jamming at feeding.
The dosing unit 2 is loaded by a spring 9 in order to press the dosing unit against the scraping unit. Between the dosing unit, which has a toothed ring 13, and the spring there is situated a disc 14 which is keyed to the storage chamber. The operating unit 1, against which the other end of the spring 9 abuts, carries a resilient arm 12 which is engageable with the toothed ring 13. Thus the disc 14, in effect, controls the angular movement of the operating unit 1 and the dosing unit 2 so that one of the recesses 7 will always stop in the correct position that is immediately below the dispensing channel 5 as shown in Figure 1. Furthermore, the disc 14 reduces the friction between the spring and the dosing unit.
13~327 In the operating unit 1 there is provided a space 10, as illustrated closed by a porous pad and into the space 10 can be inserted a drying agent such as silica gel in order to protect the contents of the device from the humidity of the air. The ingress of humidity will S also be reduced by the provision of the hood 6.
The particulate pharmaceutically active substance is stored inside the storage chamber 4 and the actual dosing operation is carried out with the dosing device in the upright position shown in Figure 1, by rotating the operating unit at first clockwise and then counter-clockwise. The ratchet mechanism formed by the toothed ring 13 and the resilient arm 12 will thus index the dosing unit so that first one and then another recess appear immediately under the dispensing channel. All of the recesses passes successively the storage chamber and can be filled with the particulate material therein. Thus, a predetermined amount of particulate pharmaceutically active substance can be dosed by the correct choice of the size of the recess 7.
The effect of the scrapers 8 on the scraping unit 3 is firstly to force and pack the particulate material into the recesses and secondly accurately to level off the particulate material at the top of the recesses. This means that when a recess 7 arrives immediately below the dispensing channel 5 it will be completely and accurately filled.
All that is then necessary is to turn the dosage device upside down and the particulate material will flow down the dispensing channel 5. By choosing the size of the recess for which ever substance is to be dispensed, one can thus choose the size of a dose which may for example be varied within wide limits, say from 1 to 5 mg or 5 to 200 mg. The number of recesses in the dosing unit may vary depending on different factors, such as the amount of active substance which should be administered in each dose, the physical properties of the active substances and so on. In a preferred embodiment, the dosing unit has six recesses and these recesses are preferably cylindrical or preferably frustoconical as shown and should preferably hold 1 dose of active substance.
13~4327 s The size of the storage chamber may be chosen to suit the requirements expected for a particu1ar active substance. In the dosage device the chamber may, for example, contain sufficient active substance for about 100 doses. The dosage device has an opening for filling or refilling of active substance in the upper part of the storage chamber. The opening is preferably sealed by a plastic plug 11.
In an alternative embodiment the dosage device has a resilient key which makes it possible to feed the device with one hand. Each push on the key causes indexing of the dosing device so that a recess filled with the active substance is placed in communication with the dispensing channel.
The dosage device may be used as container and aid in dispensing 1~ of a great number of active substances such as enprophylline, theophylline and terbutaline.
The best mode of carrying out the invention known at present is illustrated in Figure 1.
Example In order to demonstrate the dosage accuracy of the dosage device according to the present invention the following tests have been carried out with different dosing units with different sizes of the recesses A-G. The container was filled with Theo-Dur~ Sprinkle A~ substance (which is a slow release microencapsulated preparation of theophylline) mixed with 1 and 2% of talcum respectively. When the dosage accuracy of 500 doses was established a maximum deviation of 3.5% was obtained. Cf. the table below.
~ ~4 6~ h ar~
i3~4327 Test with seven different dosage units containing Theo-Dur Sprinkle substance mixed with talcum .
The figures below are the average values of 500 doses from each dosage device.
_ __ Dosage ¦ Talcum unit ' ~ 1% 2%
I mg/dose Srel %mg/dose Srel %
, , A ,104.1 2.15 2.1104.2 2.45 2.4 B 94.0 2.36 2.594.0 2.66 2.8 C ,85.4 2.29 2.784.8 2.30 2.7 D ,73.2 2.45 3.375.1 1.73 2.3 E 64.7 1.68 2.664.5 2.02 3.1 F ~54.3 1.33 2.553.4 1.87 3.5 G 145.8 1.34 2.945.9 1.30 2.8 As a comparison reference is made to Pharm. Nord, which specifies that 90% of the capsules shall have a weight which does not deviate more than 10% from the stipulated weight. The rest shall not deviate more than 20%. With the new dosage device according to the invention these requirements are thus met with an ample margin.
Several preparations of drugs are nowadays administered in micronized or granulated form or in the form of microcapsules.
These substances are filled into capsules of hard gelatine, which are intended for oral administration and are swallowed whole by the patient. Children and adults who have difficulties in swallowing a whole capsule are recommended to open the capsule and spread the contents on a suitable piece of food and to swallow.
It is, however, difficult to open the capsule and pour out the contents without any loss of the substance. Capsules of hard gelatine are an expensive, but effective, way to administer pharmacologically active substances to patients, who are able to swallow the capsules unbroken. It is, however, not sensible to use this expensive way of dispensing into capsules of hard gelatine, when the patient later on, with some difficulty, opens the capsule and pours out the contents.
It has previously been proposed to provide dosage devices to enable the particulate material to be dispensed accurately. For example DE-A-2 052 051 describes a dosage device comprising an operating unit and a storage chamber. The operating unit is fitted relatively loosely to the casing of the device.
Substances having small particles thus easily fall on the sliding C
13~4327 surfaces between the two relatively movable units, so that substance being fed jams. With such a dosage device, which does not have a feediny under force it is difficult to dose small amounts of micronized or granulated substances with an accuracy which is sufficient for the dispensing of drugs.
According to the present invention there is provided in a device for releasing a dosage of a particulate medication that includes:
a dosage dispensing unit having a face ~ith a plurality of recesses therein adapted to receive and meter a reproducible amount of said medication, a storage chamber adapted to contain the medication and having a face thereon and an outlet opening on said face which is mounted in slidable, abutting relation to the face of said dispensing unit, and a dispensing tube having a first open end through which medication can be discharged and a second open end mounted in slidable abutting relation to the face of said dispensing unit, the improvement wherein (1) said dispensing unit is mounted for rotation around an axis, and said recesses, the outlet opening of said storage chamber and the second end of said dispensing tube are all disposed in relation to said axis, such that, upon rotation of said dispensing unit, said recesses are rotated successively between operative engagement with the outlet opening of said storage chamber fox reception of medication and operative engagement with the second end of said dispensing tube for discharge of medication, (2) there is a resilient scraper located in the outlet opening of the storage chamber in sliding, resilient contact with the face of said dispensing unlt and 130~32~
configured and disposed relative to the axis of rotatlon such that it first pushes medication into the recess and then removes excess medication from above said recesses during rotation of said dispensing unit and insure that each recess contains a reproducible amount of medication, (3) said dispensing unit has ratchet means thereon arranged around the axis on which said unit rotates, (4) said device has ratchet engaging means mounted for rotation around the axis on whlch said dispensing unit rotates, said ratchet engaging means being in slidable spring-loaded contact with said ratchet means, (5) said ratchet means and ratchet engaging means are adapted to cooperate with each other such that rotation of said engaging means in one rotational direction will cause said dispensing unit to rotate in the same direction to a plurality of stations wherein at each station at least one of the recesses in said dispensing unit is in mating relation to the outlet opening in said storage chamber and another of said recesses is in mating relation to the second end of said dispensing tube and such that said engaging means will release from said ratchet means as the ratchet engaging means is rotated in the opposite rotational direction, and (6) the device has stop means coacting between the ratchet engaging means and the storage chamber for stoping the dispensing unit at each station and preventing it from advancing to the next station until the ratchet means has been released, the ratchet engaging means has been rotated in said opposite rotational direction, and the ratchet means corresponding to the next station has been engaged.
2a C
13~4327 With the construction according to the present invention, the substance is prevented from getting into contact with the sliding surfaces in the two relatively movable parts of the dosage device and in this way feeding of each dose can be achieved wlthout any problems. In the dosage device according to the invention, the scrapers make it possible to fill the recesses in the dosing unit in an accurately reproducible way. A high dosage accuracy can thus be obtained by the rotation of the dosing unit.
In order that the invention may more readily be understood, the following description is given, merely by way of example, reference being made to the accompanying drawing, in which:
Figure 1 is an axial cross-section of one embodiment of dosage device according to the invention, and Figure 2 is a cross-section taken along the line II-II of Figure 1.
The dosage device of the present invention, is preferably produced in plastic and can be considered to comprise four separate units as follows:
2b C
~3~4327 an operating unit 1 at the bottom of the dosage device;
a spring loaded dosing unit 2;
a scraping unit 3; and a storage chamber 4 provided with a dispensing channel 5 for the dose to be dispensed.
A further separate part is shown in the drawings and is preferred.
but is not essential, this being in the form of a plastic or metal hood 6 which can be retained by a peripheral rib (not shown) at the upper part of the operating unit 1. This rib enables the hood to be removably retained. An alternative way of sealing the device is to provide a plug in the top of the dispensing channel 5.
At the lower mid part of the storage chamber 4, the scraping unit 3 is fixed to the inner wall of the storage chamber so that it cannot rotate relative thereto. The scraping unit in fact includes the lower part of the dispensing channel 5 which is formed integrally with the storage chamber 4. From Figure 2 it will be seen more clearly that the scraping unit 3 includes 5 radially extending arms each of which carries a resilient scraper 8 in sliding contact with the upper surface of the dosing unit 2 which, in turn, is provided with six circumferentially spaced slightly frustoconical recesses 7 positioned immediately under the scrapers 8. In order to guide for rotation of the dosing unit 2, the scraping unit has an outer peripheral skirt engaging the cylindrical outer surface of the dosing unit 2 and a short inner annulus engaging the upper surface of the dosing unit inwardly of the recesses 7 in order to prevent jamming at feeding.
The dosing unit 2 is loaded by a spring 9 in order to press the dosing unit against the scraping unit. Between the dosing unit, which has a toothed ring 13, and the spring there is situated a disc 14 which is keyed to the storage chamber. The operating unit 1, against which the other end of the spring 9 abuts, carries a resilient arm 12 which is engageable with the toothed ring 13. Thus the disc 14, in effect, controls the angular movement of the operating unit 1 and the dosing unit 2 so that one of the recesses 7 will always stop in the correct position that is immediately below the dispensing channel 5 as shown in Figure 1. Furthermore, the disc 14 reduces the friction between the spring and the dosing unit.
13~327 In the operating unit 1 there is provided a space 10, as illustrated closed by a porous pad and into the space 10 can be inserted a drying agent such as silica gel in order to protect the contents of the device from the humidity of the air. The ingress of humidity will S also be reduced by the provision of the hood 6.
The particulate pharmaceutically active substance is stored inside the storage chamber 4 and the actual dosing operation is carried out with the dosing device in the upright position shown in Figure 1, by rotating the operating unit at first clockwise and then counter-clockwise. The ratchet mechanism formed by the toothed ring 13 and the resilient arm 12 will thus index the dosing unit so that first one and then another recess appear immediately under the dispensing channel. All of the recesses passes successively the storage chamber and can be filled with the particulate material therein. Thus, a predetermined amount of particulate pharmaceutically active substance can be dosed by the correct choice of the size of the recess 7.
The effect of the scrapers 8 on the scraping unit 3 is firstly to force and pack the particulate material into the recesses and secondly accurately to level off the particulate material at the top of the recesses. This means that when a recess 7 arrives immediately below the dispensing channel 5 it will be completely and accurately filled.
All that is then necessary is to turn the dosage device upside down and the particulate material will flow down the dispensing channel 5. By choosing the size of the recess for which ever substance is to be dispensed, one can thus choose the size of a dose which may for example be varied within wide limits, say from 1 to 5 mg or 5 to 200 mg. The number of recesses in the dosing unit may vary depending on different factors, such as the amount of active substance which should be administered in each dose, the physical properties of the active substances and so on. In a preferred embodiment, the dosing unit has six recesses and these recesses are preferably cylindrical or preferably frustoconical as shown and should preferably hold 1 dose of active substance.
13~4327 s The size of the storage chamber may be chosen to suit the requirements expected for a particu1ar active substance. In the dosage device the chamber may, for example, contain sufficient active substance for about 100 doses. The dosage device has an opening for filling or refilling of active substance in the upper part of the storage chamber. The opening is preferably sealed by a plastic plug 11.
In an alternative embodiment the dosage device has a resilient key which makes it possible to feed the device with one hand. Each push on the key causes indexing of the dosing device so that a recess filled with the active substance is placed in communication with the dispensing channel.
The dosage device may be used as container and aid in dispensing 1~ of a great number of active substances such as enprophylline, theophylline and terbutaline.
The best mode of carrying out the invention known at present is illustrated in Figure 1.
Example In order to demonstrate the dosage accuracy of the dosage device according to the present invention the following tests have been carried out with different dosing units with different sizes of the recesses A-G. The container was filled with Theo-Dur~ Sprinkle A~ substance (which is a slow release microencapsulated preparation of theophylline) mixed with 1 and 2% of talcum respectively. When the dosage accuracy of 500 doses was established a maximum deviation of 3.5% was obtained. Cf. the table below.
~ ~4 6~ h ar~
i3~4327 Test with seven different dosage units containing Theo-Dur Sprinkle substance mixed with talcum .
The figures below are the average values of 500 doses from each dosage device.
_ __ Dosage ¦ Talcum unit ' ~ 1% 2%
I mg/dose Srel %mg/dose Srel %
, , A ,104.1 2.15 2.1104.2 2.45 2.4 B 94.0 2.36 2.594.0 2.66 2.8 C ,85.4 2.29 2.784.8 2.30 2.7 D ,73.2 2.45 3.375.1 1.73 2.3 E 64.7 1.68 2.664.5 2.02 3.1 F ~54.3 1.33 2.553.4 1.87 3.5 G 145.8 1.34 2.945.9 1.30 2.8 As a comparison reference is made to Pharm. Nord, which specifies that 90% of the capsules shall have a weight which does not deviate more than 10% from the stipulated weight. The rest shall not deviate more than 20%. With the new dosage device according to the invention these requirements are thus met with an ample margin.
Claims (3)
1. In a device for releasing a dosage of a particulate medication that includes:
a dosage dispensing unit having a face with a plurality of recesses therein adapted to receive and meter a reproducible amount of said medication, a storage chamber adapted to contain the medication and having a face thereon and an outlet opening on said face which is mounted in slidable, abutting relation to the face of said dispensing unit, and a dispensing tube having a first open end through which medication can be discharged and a second open end mounted in slidable abutting relation to the face of said dispensing unit, the improvement wherein (1) said dispensing unit is mounted for rotation around an axis, and said recesses, the outlet opening of said storage chamber and the second end of said dispensing tube are all disposed in relation to said axis, such that, upon rotation of said dispensing unit, said recesses are rotated successively between operative engagement with the outlet opening of said storage chamber for reception of medication and operative engagement with the second end of said dispensing tube for discharge of medication, (2) there is a resilient scraper located in the outlet opening of the storage chamber in sliding, resilient contact with the face of said dispensing unit and configured and disposed relative to the axis of rotation such that it first pushes medication into the recess and then removes excess medication from above said recesses during rotation of said dispensing unit and insure that each recess contains a reproducible amount of medication, (3) said dispensing unit has ratchet means thereon arranged around the axis on which said unit rotates, (4) said device has ratchet engaging means mounted for rotation around the axis on which said dispensing unit rotates, said ratchet engaging means being in slidable spring-loaded contact with said ratchet means, (5) said ratchet means and ratchet engaging means are adapted to cooperate with each other such that rotation of said engaging means in one rotational direction will cause said dispensing unit to rotate in the same direction to a plurality of stations wherein at each station at least one of the recesses in said dispensing unit is in mating relation to the outlet opening in said storage chamber and another of said recesses is in mating relation to the second end of said dispensing tube and such that said engaging means will release from said ratchet means as the ratchet engaging means is rotated in the opposite rotational direction, and (6) the device has stop means coacting between the ratchet engaging means and the storage chamber for stoping the dispensing unit at each station and preventing it from advancing to the next station until the ratchet means has been released, the ratchet engaging means has been rotated in said opposite rotational direction, and the ratchet means corresponding to the next station has been engaged.
a dosage dispensing unit having a face with a plurality of recesses therein adapted to receive and meter a reproducible amount of said medication, a storage chamber adapted to contain the medication and having a face thereon and an outlet opening on said face which is mounted in slidable, abutting relation to the face of said dispensing unit, and a dispensing tube having a first open end through which medication can be discharged and a second open end mounted in slidable abutting relation to the face of said dispensing unit, the improvement wherein (1) said dispensing unit is mounted for rotation around an axis, and said recesses, the outlet opening of said storage chamber and the second end of said dispensing tube are all disposed in relation to said axis, such that, upon rotation of said dispensing unit, said recesses are rotated successively between operative engagement with the outlet opening of said storage chamber for reception of medication and operative engagement with the second end of said dispensing tube for discharge of medication, (2) there is a resilient scraper located in the outlet opening of the storage chamber in sliding, resilient contact with the face of said dispensing unit and configured and disposed relative to the axis of rotation such that it first pushes medication into the recess and then removes excess medication from above said recesses during rotation of said dispensing unit and insure that each recess contains a reproducible amount of medication, (3) said dispensing unit has ratchet means thereon arranged around the axis on which said unit rotates, (4) said device has ratchet engaging means mounted for rotation around the axis on which said dispensing unit rotates, said ratchet engaging means being in slidable spring-loaded contact with said ratchet means, (5) said ratchet means and ratchet engaging means are adapted to cooperate with each other such that rotation of said engaging means in one rotational direction will cause said dispensing unit to rotate in the same direction to a plurality of stations wherein at each station at least one of the recesses in said dispensing unit is in mating relation to the outlet opening in said storage chamber and another of said recesses is in mating relation to the second end of said dispensing tube and such that said engaging means will release from said ratchet means as the ratchet engaging means is rotated in the opposite rotational direction, and (6) the device has stop means coacting between the ratchet engaging means and the storage chamber for stoping the dispensing unit at each station and preventing it from advancing to the next station until the ratchet means has been released, the ratchet engaging means has been rotated in said opposite rotational direction, and the ratchet means corresponding to the next station has been engaged.
2. A device according to claim 1 wherein spring means are included to maintain said dosage dispensing unit in slidable abutting relationship to the outlet opening of said storage chamber and the second end of said dispensing tube.
3. A device according to claim 1 or claim 2 wherein said storage chamber is disposed relative to said dosage dispensing unit such that medication contained in the storage chamber will fall under the influence of gravity into the recesses of the dosage dispensing unit and the scrapers are arranged to scrape downwardly against the first face of said dosage dispensing unit.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8401796A SE8401796D0 (en) | 1984-04-02 | 1984-04-02 | dosing device |
| SE8401796-1 | 1984-04-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1304327C true CA1304327C (en) | 1992-06-30 |
Family
ID=20355391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000477460A Expired - Lifetime CA1304327C (en) | 1984-04-02 | 1985-03-26 | Dosage device |
Country Status (24)
| Country | Link |
|---|---|
| JP (1) | JPS60225564A (en) |
| KR (1) | KR920003127B1 (en) |
| AT (1) | AT392413B (en) |
| AU (1) | AU566240B2 (en) |
| BE (1) | BE902081A (en) |
| CA (1) | CA1304327C (en) |
| CH (1) | CH668639A5 (en) |
| DE (1) | DE3511817C2 (en) |
| DK (1) | DK162208C (en) |
| ES (1) | ES8603333A1 (en) |
| FI (1) | FI83032C (en) |
| FR (1) | FR2561912B1 (en) |
| GB (1) | GB2156783B (en) |
| GR (1) | GR850817B (en) |
| IE (1) | IE56449B1 (en) |
| IS (1) | IS1371B6 (en) |
| IT (1) | IT1181953B (en) |
| LU (1) | LU85828A1 (en) |
| NL (1) | NL192633C (en) |
| NO (1) | NO160129C (en) |
| NZ (1) | NZ211576A (en) |
| PT (1) | PT80205B (en) |
| SE (2) | SE8401796D0 (en) |
| ZA (1) | ZA851899B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4021263C2 (en) * | 1990-07-04 | 1996-04-11 | Pfeiffer Erich Gmbh & Co Kg | Discharge device for media |
| US5280846A (en) * | 1992-09-23 | 1994-01-25 | Lonnecker Bruce R | Liquid and granular fluid dispenser |
| BR9407608A (en) * | 1993-09-22 | 1997-01-14 | Senetics Inc | Indicating device and device for indicating aerosol drug release |
| US5654007A (en) * | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| TW533865U (en) | 1997-06-10 | 2003-05-21 | Glaxo Group Ltd | Dispenser for dispensing medicament and actuation indicating device |
| KR101020774B1 (en) | 2008-11-27 | 2011-03-09 | 주식회사 삼화플라스틱 | A Medicine Case Drawing Out Dose |
| GB2554738A (en) * | 2016-10-07 | 2018-04-11 | Res Center Pharmaceutical Engineering Gmbh | A system and a method for constant micro dosing and feeding of powder material |
| EP3376180B1 (en) * | 2017-03-14 | 2020-01-08 | Daneme Holding B.V. | Dispensing device for powders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2088836A (en) * | 1936-09-24 | 1937-08-03 | Walter O Brown | Measuring container for granular material |
| US2901150A (en) * | 1954-04-26 | 1959-08-25 | Gustave O Matter | Measuring dispenser |
| DE1948180U (en) * | 1966-08-10 | 1966-10-20 | Kuma Rudolf Osterhold Kunststo | CAN WITH DOSING DEVICE FOR BREWABLE GOODS. |
| DE1956458U (en) * | 1966-12-13 | 1967-03-02 | Krups Fa Robert | HOUSEHOLD DOSING DEVICE FOR FOOD. |
| US3458091A (en) * | 1967-01-16 | 1969-07-29 | Carrol O Clement | Dispenser for powdered and granular material |
| DE2052051A1 (en) * | 1970-10-23 | 1972-04-27 | Steffens, Willi, 5208 Eitorf | Container with dosing device for free-flowing powdery to granular solids |
-
1984
- 1984-04-02 SE SE8401796A patent/SE8401796D0/en unknown
-
1985
- 1985-03-08 SE SE8501129A patent/SE459781B/en not_active IP Right Cessation
- 1985-03-13 ZA ZA851899A patent/ZA851899B/en unknown
- 1985-03-15 GB GB08506731A patent/GB2156783B/en not_active Expired
- 1985-03-19 NL NL8500799A patent/NL192633C/en not_active IP Right Cessation
- 1985-03-20 IE IE714/85A patent/IE56449B1/en not_active IP Right Cessation
- 1985-03-21 NO NO851146A patent/NO160129C/en not_active IP Right Cessation
- 1985-03-25 CH CH1323/85A patent/CH668639A5/en not_active IP Right Cessation
- 1985-03-26 CA CA000477460A patent/CA1304327C/en not_active Expired - Lifetime
- 1985-03-26 DK DK135585A patent/DK162208C/en not_active IP Right Cessation
- 1985-03-26 NZ NZ211576A patent/NZ211576A/en unknown
- 1985-03-26 IT IT47873/85A patent/IT1181953B/en active
- 1985-03-26 AU AU40373/85A patent/AU566240B2/en not_active Expired
- 1985-03-29 KR KR1019850002097A patent/KR920003127B1/en not_active IP Right Cessation
- 1985-03-29 FR FR8504808A patent/FR2561912B1/en not_active Expired - Lifetime
- 1985-03-30 DE DE3511817A patent/DE3511817C2/en not_active Expired - Lifetime
- 1985-04-01 PT PT80205A patent/PT80205B/en unknown
- 1985-04-01 LU LU85828A patent/LU85828A1/en unknown
- 1985-04-01 GR GR850817A patent/GR850817B/el unknown
- 1985-04-01 IS IS2996A patent/IS1371B6/en unknown
- 1985-04-01 AT AT968/85A patent/AT392413B/en not_active IP Right Cessation
- 1985-04-01 ES ES541813A patent/ES8603333A1/en not_active Expired
- 1985-04-01 BE BE0/214757A patent/BE902081A/en not_active IP Right Cessation
- 1985-04-01 JP JP60066732A patent/JPS60225564A/en active Granted
- 1985-04-01 FI FI851302A patent/FI83032C/en not_active IP Right Cessation
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