GB2116180B - Cephalosporin derivatives - Google Patents

Cephalosporin derivatives

Info

Publication number
GB2116180B
GB2116180B GB08305940A GB8305940A GB2116180B GB 2116180 B GB2116180 B GB 2116180B GB 08305940 A GB08305940 A GB 08305940A GB 8305940 A GB8305940 A GB 8305940A GB 2116180 B GB2116180 B GB 2116180B
Authority
GB
United Kingdom
Prior art keywords
cephalosporin derivatives
cephalosporin
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08305940A
Other languages
English (en)
Other versions
GB8305940D0 (en
GB2116180A (en
Inventor
Shimpei Aburaki
Hajime Kamachi
Yukio Narita
Jun Okumura
Takayuki Naito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/354,851 external-priority patent/US4406899A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of GB8305940D0 publication Critical patent/GB8305940D0/en
Publication of GB2116180A publication Critical patent/GB2116180A/en
Application granted granted Critical
Publication of GB2116180B publication Critical patent/GB2116180B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB08305940A 1982-03-04 1983-03-03 Cephalosporin derivatives Expired GB2116180B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/354,851 US4406899A (en) 1982-03-04 1982-03-04 Cephalosporins
US35753482A 1982-03-12 1982-03-12

Publications (3)

Publication Number Publication Date
GB8305940D0 GB8305940D0 (en) 1983-04-07
GB2116180A GB2116180A (en) 1983-09-21
GB2116180B true GB2116180B (en) 1985-09-18

Family

ID=26998584

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08305940A Expired GB2116180B (en) 1982-03-04 1983-03-03 Cephalosporin derivatives

Country Status (29)

Country Link
KR (1) KR870001986B1 (hu)
AT (2) AT382155B (hu)
AU (1) AU562776B2 (hu)
BE (1) BE896086A (hu)
CA (1) CA1213882A (hu)
CH (1) CH654313A5 (hu)
CS (1) CS249512B2 (hu)
DD (1) DD210280A5 (hu)
DE (1) DE3307550A1 (hu)
DK (1) DK156900C (hu)
EG (1) EG15934A (hu)
ES (2) ES520224A0 (hu)
FI (1) FI74973C (hu)
FR (1) FR2522659B1 (hu)
GB (1) GB2116180B (hu)
GR (1) GR77916B (hu)
HU (1) HU193158B (hu)
IE (1) IE56647B1 (hu)
IL (1) IL68011A0 (hu)
IT (1) IT1170307B (hu)
LU (1) LU84674A1 (hu)
MY (1) MY8700943A (hu)
NL (2) NL193284C (hu)
NZ (1) NZ203312A (hu)
PH (1) PH18002A (hu)
PT (1) PT76330B (hu)
SE (1) SE453091B (hu)
SU (1) SU1250173A3 (hu)
YU (2) YU43822B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409431A1 (de) * 1983-10-08 1985-04-18 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3404906A1 (de) * 1984-02-11 1985-08-14 Bayer Ag, 5090 Leverkusen 1-oxadethiacephalosporinderivate sowie verfahren zu ihrer herstellung
DE3419013A1 (de) * 1984-05-22 1985-11-28 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
GB8424692D0 (en) * 1984-10-01 1984-11-07 Glaxo Group Ltd Chemical compounds
US4698336A (en) * 1985-01-30 1987-10-06 Eisai Co., Ltd. 3-(pyrrolidinio)methyl-3-cephem derivatives
US4910301A (en) * 1985-08-05 1990-03-20 Bristol-Myers Company Cefepime cephalosporin salts
CA1284994C (en) * 1985-08-05 1991-06-18 Murray Arthur Kaplan Cephalosporin salts and injectable compositions
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
EP0237735B1 (en) * 1986-03-17 1994-03-30 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-3-cephem compounds and process for production of the same
CA2011116C (en) * 1989-03-06 1999-11-16 Murray A. Kaplan Lyophilized bmy-28142 dihydrochloride for parenteral use
DE69231815T2 (de) 1991-03-08 2001-09-27 Biochemie Ges.M.B.H., Kundl Verfahren zur Herstellung von Cephalosporinen und Zwischenprodukte in diesem Verfahren
YU81692A (sh) * 1991-09-10 1995-03-27 Bristol-Myers Co. Postupak za proizvodnju cefalosporinskog antibiotika
IL103110A (en) * 1991-09-10 1997-04-15 Bristol Myers Squibb Co Anhydrous process for preparing cefepime dihydrochloride hydrate
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
CN100543027C (zh) * 2003-12-23 2009-09-23 桑多斯有限公司 制备用于合成头孢菌素的中间体的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
GB1591439A (en) * 1976-10-01 1981-06-24 Glaxo Operations Ltd 7-syn (oxyimino -acylamido) cephalosporins
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
CH644867A5 (de) * 1978-10-27 1984-08-31 Glaxo Group Ltd In der 3- und 7-stellung substituierte cephemcarbonsaeuren.
US4443444A (en) * 1980-08-11 1984-04-17 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds

Also Published As

Publication number Publication date
AT382155B (de) 1987-01-26
ATA228285A (de) 1987-05-15
FI830689A0 (fi) 1983-03-01
IT8347826A0 (it) 1983-03-01
NZ203312A (en) 1985-12-13
SE453091B (sv) 1988-01-11
GR77916B (hu) 1984-09-25
IE56647B1 (en) 1991-10-23
ATA76183A (de) 1986-06-15
PH18002A (en) 1985-02-28
DK86283A (da) 1983-09-05
EG15934A (en) 1987-10-30
FI74973C (fi) 1988-04-11
NL8300755A (nl) 1983-10-03
YU149685A (en) 1986-02-28
NL193284B (nl) 1999-01-04
PT76330A (en) 1983-04-01
IL68011A0 (en) 1983-06-15
IE830455L (en) 1983-09-04
DK86283D0 (da) 1983-02-24
MY8700943A (en) 1987-12-31
NL193284C (nl) 1999-05-06
YU52383A (en) 1986-02-28
IT1170307B (it) 1987-06-03
DE3307550C2 (hu) 1988-11-24
NL990039I2 (nl) 2000-04-03
ES526397A0 (es) 1985-09-16
ES8507557A1 (es) 1985-09-16
BE896086A (fr) 1983-09-05
DK156900B (da) 1989-10-16
LU84674A1 (fr) 1983-11-17
DD210280A5 (de) 1984-06-06
SE8301178D0 (sv) 1983-03-03
CS249512B2 (en) 1987-03-12
YU44777B (en) 1991-02-28
DE3307550A1 (de) 1983-09-15
HU193158B (en) 1987-08-28
DK156900C (da) 1990-03-12
NL990039I1 (nl) 2000-01-03
FR2522659B1 (fr) 1986-10-24
AU562776B2 (en) 1987-06-18
SU1250173A3 (ru) 1986-08-07
KR840004118A (ko) 1984-10-06
FI830689L (fi) 1983-09-05
CA1213882A (en) 1986-11-12
FI74973B (fi) 1987-12-31
CH654313A5 (de) 1986-02-14
AU1130483A (en) 1983-09-08
ES8403919A1 (es) 1984-04-01
FR2522659A1 (fr) 1983-09-09
YU43822B (en) 1989-12-31
SE8301178L (sv) 1983-09-05
KR870001986B1 (ko) 1987-10-24
GB8305940D0 (en) 1983-04-07
AT384612B (de) 1987-12-10
GB2116180A (en) 1983-09-21
PT76330B (en) 1986-02-04
ES520224A0 (es) 1984-04-01

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20030302