GB2088382B - 16a-hydroxy-17a-amino pregnanes their synthesis and their conversion to pregnano(17a,16a-d) oxazolines - Google Patents

16a-hydroxy-17a-amino pregnanes their synthesis and their conversion to pregnano(17a,16a-d) oxazolines

Info

Publication number
GB2088382B
GB2088382B GB8134907A GB8134907A GB2088382B GB 2088382 B GB2088382 B GB 2088382B GB 8134907 A GB8134907 A GB 8134907A GB 8134907 A GB8134907 A GB 8134907A GB 2088382 B GB2088382 B GB 2088382B
Authority
GB
United Kingdom
Prior art keywords
pregnano
pregnanes
oxazolines
hydroxy
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8134907A
Other languages
English (en)
Other versions
GB2088382A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of GB2088382A publication Critical patent/GB2088382A/en
Application granted granted Critical
Publication of GB2088382B publication Critical patent/GB2088382B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB8134907A 1980-11-26 1981-11-19 16a-hydroxy-17a-amino pregnanes their synthesis and their conversion to pregnano(17a,16a-d) oxazolines Expired GB2088382B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26229/80A IT1134455B (it) 1980-11-26 1980-11-26 Procedimento per la preparazione di derivati 16alfa-idrossi-17alfa-aminopregnanici

Publications (2)

Publication Number Publication Date
GB2088382A GB2088382A (en) 1982-06-09
GB2088382B true GB2088382B (en) 1984-12-12

Family

ID=11218998

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8134907A Expired GB2088382B (en) 1980-11-26 1981-11-19 16a-hydroxy-17a-amino pregnanes their synthesis and their conversion to pregnano(17a,16a-d) oxazolines

Country Status (16)

Country Link
US (1) US4412953A (enExample)
JP (3) JPS57118600A (enExample)
KR (1) KR870001903B1 (enExample)
AU (1) AU548998B2 (enExample)
BE (1) BE891242A (enExample)
CA (1) CA1176239A (enExample)
CH (1) CH657860A5 (enExample)
DE (1) DE3146785C2 (enExample)
FR (1) FR2494699A1 (enExample)
GB (1) GB2088382B (enExample)
HK (1) HK91086A (enExample)
IT (1) IT1134455B (enExample)
MY (1) MY8700182A (enExample)
NL (1) NL194645C (enExample)
NZ (1) NZ199056A (enExample)
SG (1) SG65486G (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2683530B1 (fr) * 1991-11-08 1994-01-21 Roussel Uclaf Nouveau procede de preparation de derives 20-oxo 17 alpha, 21-dihydroxyles du pregnane et nouveaux intermediaires.
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US20050101581A1 (en) * 2002-08-28 2005-05-12 Reading Christopher L. Therapeutic treatment methods 2
WO2004019953A1 (en) * 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH444859A (de) * 1962-02-20 1967-10-15 Richter Gedeon Vegyeszet Verfahren zur Herstellung von neuen, im D-Ring basisch substituierten, 3-Keto-Steroiden
NL128816C (enExample) * 1965-04-22
IL31997A (en) * 1968-05-03 1974-03-14 Lepetit Spa Process for the preparation of pregnano(17alpha,16alpha-d)oxazolines and 16alpha,21-dihydroxy-17alpha-aminopregnanes
US4031075A (en) * 1973-07-11 1977-06-21 Akzona Incorporated Alkylated pregnanes and process for obtaining same
GB1478968A (en) * 1973-07-11 1977-07-06 Akzo Nv Alkylated pregnanes

Also Published As

Publication number Publication date
SG65486G (en) 1987-03-27
CH657860A5 (it) 1986-09-30
NL8105201A (nl) 1982-06-16
DE3146785C2 (de) 1997-06-12
KR870001903B1 (ko) 1987-10-21
IT1134455B (it) 1986-08-13
NL194645B (nl) 2002-06-03
NZ199056A (en) 1984-07-06
JPH01238598A (ja) 1989-09-22
HK91086A (en) 1986-12-05
US4412953A (en) 1983-11-01
JPH01131194A (ja) 1989-05-24
DE3146785A1 (de) 1982-07-01
AU548998B2 (en) 1986-01-09
MY8700182A (en) 1987-12-31
KR830007714A (ko) 1983-11-04
JPH0124159B2 (enExample) 1989-05-10
IT8026229A0 (it) 1980-11-26
FR2494699A1 (fr) 1982-05-28
JPH0160479B2 (enExample) 1989-12-22
BE891242A (fr) 1982-05-25
AU7786381A (en) 1982-06-03
NL194645C (nl) 2002-10-04
GB2088382A (en) 1982-06-09
CA1176239A (en) 1984-10-16
JPS57118600A (en) 1982-07-23
FR2494699B1 (enExample) 1983-12-09

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Effective date: 20011118