GB2060604B - E15-(2-halogenovinyl)-2'-deoxycytidines - Google Patents

E15-(2-halogenovinyl)-2'-deoxycytidines

Info

Publication number
GB2060604B
GB2060604B GB7934248A GB7934248A GB2060604B GB 2060604 B GB2060604 B GB 2060604B GB 7934248 A GB7934248 A GB 7934248A GB 7934248 A GB7934248 A GB 7934248A GB 2060604 B GB2060604 B GB 2060604B
Authority
GB
United Kingdom
Prior art keywords
halogenovinyl
deoxycytidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7934248A
Other languages
English (en)
Other versions
GB2060604A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIRMINGHAM AND STICHTING, University of
Original Assignee
BIRMINGHAM AND STICHTING, University of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIRMINGHAM AND STICHTING, University of filed Critical BIRMINGHAM AND STICHTING, University of
Priority to GB7934248A priority Critical patent/GB2060604B/en
Priority to SE8006669A priority patent/SE445740B/sv
Priority to NL8005336A priority patent/NL8005336A/nl
Priority to DE19803036131 priority patent/DE3036131A1/de
Priority to CH7181/80A priority patent/CH647245A5/de
Priority to BE1/9967A priority patent/BE885415A/nl
Priority to JP13861580A priority patent/JPS5695198A/ja
Priority to IT8009551A priority patent/IT1209758B/it
Priority to FR8021170A priority patent/FR2466472A1/fr
Priority to US06/193,251 priority patent/US4382925A/en
Priority to CA000361953A priority patent/CA1173438A/en
Publication of GB2060604A publication Critical patent/GB2060604A/en
Application granted granted Critical
Publication of GB2060604B publication Critical patent/GB2060604B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
GB7934248A 1979-10-03 1979-10-03 E15-(2-halogenovinyl)-2'-deoxycytidines Expired GB2060604B (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
GB7934248A GB2060604B (en) 1979-10-03 1979-10-03 E15-(2-halogenovinyl)-2'-deoxycytidines
SE8006669A SE445740B (sv) 1979-10-03 1980-09-24 E-5-(2-halogenvinyl)-2'-deoxicytidin, sett for framstellning derav samt farmaceutisk komposition innehallande e-5-(2-halogenvinyl)-2'-deoxicytidin
NL8005336A NL8005336A (nl) 1979-10-03 1980-09-24 E-5-(2-halogeenvinyl)-2'-deoxycytidinen.
DE19803036131 DE3036131A1 (de) 1979-10-03 1980-09-25 Neue desoxycytidin-verbindungen, deren herstellung und diese enthaltende pharmazeutische zubereitungen
CH7181/80A CH647245A5 (de) 1979-10-03 1980-09-25 Desoxycytidin-verbindungen, deren herstellung und diese enthaltende pharmazeutische zubereitung.
BE1/9967A BE885415A (nl) 1979-10-03 1980-09-26 E-5-(2-halogeenvinyl)-2'-deoxycytidinen
JP13861580A JPS5695198A (en) 1979-10-03 1980-10-02 Ee55*22halogenovinyl**2**deoxycytidines
IT8009551A IT1209758B (it) 1979-10-03 1980-10-02 E-5-(2-alogenovinil-)-2'deossicitidine, loro metodo di preparazione e loro impiego per il trattamentodi malattie da virus
FR8021170A FR2466472A1 (fr) 1979-10-03 1980-10-02 E-5-(2-halogenovinyl)-2'-desoxycytydines; leur procede de preparation et leur utilisation dans des compositions pharmaceutiques pour le traitement de maladies a virus
US06/193,251 US4382925A (en) 1979-10-03 1980-10-02 E-5-(2-Halogenovinyl)-2'-deoxycytidines
CA000361953A CA1173438A (en) 1979-10-03 1980-10-03 E - 5 - (2-halogenovinyl) - 2' - deoxycytidines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7934248A GB2060604B (en) 1979-10-03 1979-10-03 E15-(2-halogenovinyl)-2'-deoxycytidines

Publications (2)

Publication Number Publication Date
GB2060604A GB2060604A (en) 1981-05-07
GB2060604B true GB2060604B (en) 1983-11-23

Family

ID=10508255

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7934248A Expired GB2060604B (en) 1979-10-03 1979-10-03 E15-(2-halogenovinyl)-2'-deoxycytidines

Country Status (11)

Country Link
US (1) US4382925A (enExample)
JP (1) JPS5695198A (enExample)
BE (1) BE885415A (enExample)
CA (1) CA1173438A (enExample)
CH (1) CH647245A5 (enExample)
DE (1) DE3036131A1 (enExample)
FR (1) FR2466472A1 (enExample)
GB (1) GB2060604B (enExample)
IT (1) IT1209758B (enExample)
NL (1) NL8005336A (enExample)
SE (1) SE445740B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
JPS5843993A (ja) * 1981-09-09 1983-03-14 Yamasa Shoyu Co Ltd １−β−Ｄ−アラビノフラノシル−（Ｅ）−５−（２−ハロゲノビニル）ウラシル−５′−りん酸およびその製造法
EP0080305A1 (en) * 1981-11-19 1983-06-01 Beecham Group Plc Antiviral 2'-deoxyuridines, their preparation and use
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
FI832884A7 (fi) * 1982-08-17 1984-02-18 Sandoz Ag Desoksiuridiini-johdannaiset, niiden valmistusmenetelmät ja käyttö farmaseuttisina aineina.
US4564618A (en) * 1982-09-17 1986-01-14 Glaxo Group Limited 5-Halovinyl-2'-deoxyuridine derivatives
US4666892A (en) * 1984-03-06 1987-05-19 Sloan-Kettering Memorial Cancer Center Method and composition for hepatitis treatment with pyrimidine nucleoside compounds
HU198393B (en) * 1984-03-06 1989-10-30 Sloan Kettering Inst Cancer Process for production of medical composition suitable for treatment of hepatitis containing as active substance derivatives of piramidin-nucleoside
US4762823A (en) * 1985-10-16 1988-08-09 Sloan-Kettering Institute For Cancer Research Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
EP0428623A4 (en) * 1988-08-10 1993-12-08 Stephen Leslie Sacks Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac
EP1284720B1 (en) * 2000-03-29 2006-09-13 Georgetown University L-fmau for the treatment of hepatitis delta viral infection
JP4651942B2 (ja) 2001-12-20 2011-03-16 フアーマセツト・インコーポレイテッド Ｅｂｖ及びｋｈｓｖ感染並びにそれに伴う異常細胞増殖の治療
JP2008174524A (ja) * 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US4000260A (en) * 1974-08-29 1976-12-28 Research Corporation Anti herpes simplex viral compounds and their synthesis
US4024143A (en) * 1976-03-11 1977-05-17 Pcr, Inc. Silylation of 5-fluoro-6-hydroxy or alkoxy pyrimidine
US4267171A (en) * 1979-07-02 1981-05-12 The Regents Of The University Of California C-5 Substituted cytosine nucleosides

Also Published As

Publication number Publication date
US4382925A (en) 1983-05-10
IT1209758B (it) 1989-08-30
JPS637199B2 (enExample) 1988-02-15
IT8009551A0 (it) 1980-10-02
CH647245A5 (de) 1985-01-15
DE3036131C2 (enExample) 1989-07-06
NL8005336A (nl) 1981-04-07
FR2466472A1 (fr) 1981-04-10
GB2060604A (en) 1981-05-07
JPS5695198A (en) 1981-08-01
SE8006669L (sv) 1981-04-04
BE885415A (nl) 1981-03-26
DE3036131A1 (de) 1981-04-16
CA1173438A (en) 1984-08-28
FR2466472B1 (enExample) 1983-12-23
SE445740B (sv) 1986-07-14

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee