GB201322602D0 - Pharmaceutical compounds - Google Patents

Pharmaceutical compounds

Info

Publication number
GB201322602D0
GB201322602D0 GBGB1322602.2A GB201322602A GB201322602D0 GB 201322602 D0 GB201322602 D0 GB 201322602D0 GB 201322602 A GB201322602 A GB 201322602A GB 201322602 D0 GB201322602 D0 GB 201322602D0
Authority
GB
United Kingdom
Prior art keywords
pharmaceutical compounds
pharmaceutical
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1322602.2A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almac Discovery Ltd
Original Assignee
Almac Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almac Discovery Ltd filed Critical Almac Discovery Ltd
Priority to GBGB1322602.2A priority Critical patent/GB201322602D0/en
Publication of GB201322602D0 publication Critical patent/GB201322602D0/en
Priority to JP2016541294A priority patent/JP6437559B2/ja
Priority to SI201430580T priority patent/SI3083625T1/en
Priority to LTEP14815843.9T priority patent/LT3083625T/lt
Priority to EP14815843.9A priority patent/EP3083625B1/en
Priority to HUE14815843A priority patent/HUE037908T2/hu
Priority to CA2933755A priority patent/CA2933755C/en
Priority to PL14815843T priority patent/PL3083625T3/pl
Priority to HRP20180080TT priority patent/HRP20180080T1/hr
Priority to NZ720178A priority patent/NZ720178A/en
Priority to RS20171338A priority patent/RS56731B1/sr
Priority to CN201480069437.9A priority patent/CN105829315B/zh
Priority to PCT/GB2014/053793 priority patent/WO2015092431A1/en
Priority to KR1020167019551A priority patent/KR102405462B1/ko
Priority to BR112016014151-2A priority patent/BR112016014151B1/pt
Priority to SM20180020T priority patent/SMT201800020T1/it
Priority to US15/105,869 priority patent/US9850247B2/en
Priority to ES14815843.9T priority patent/ES2650013T3/es
Priority to AU2014369457A priority patent/AU2014369457B2/en
Priority to MX2016007801A priority patent/MX371108B/es
Priority to PT148158439T priority patent/PT3083625T/pt
Priority to DK14815843.9T priority patent/DK3083625T3/en
Priority to RU2016123363A priority patent/RU2691105C1/ru
Priority to SG11201603814TA priority patent/SG11201603814TA/en
Priority to NO14815843A priority patent/NO3083625T3/no
Priority to IL245672A priority patent/IL245672B/en
Priority to ZA2016/03337A priority patent/ZA201603337B/en
Priority to CY20181100041T priority patent/CY1120035T1/el
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GBGB1322602.2A 2013-12-19 2013-12-19 Pharmaceutical compounds Ceased GB201322602D0 (en)

Priority Applications (28)

Application Number Priority Date Filing Date Title
GBGB1322602.2A GB201322602D0 (en) 2013-12-19 2013-12-19 Pharmaceutical compounds
NO14815843A NO3083625T3 (OSRAM) 2013-12-19 2014-12-19
PCT/GB2014/053793 WO2015092431A1 (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
BR112016014151-2A BR112016014151B1 (pt) 2013-12-19 2014-12-19 Pirirmidopirimidinonas úteis como inibidores de quinases wee-1
LTEP14815843.9T LT3083625T (lt) 2013-12-19 2014-12-19 Pirimidopirimidinonai, tinkami naudoti kaip wee-1 kinazės inhibitoriai
EP14815843.9A EP3083625B1 (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
HUE14815843A HUE037908T2 (hu) 2013-12-19 2014-12-19 Pirimodopirimidononok mint WEE-1 kináz inhibitorok
CA2933755A CA2933755C (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
PL14815843T PL3083625T3 (pl) 2013-12-19 2014-12-19 Pirymidopirymidynony użyteczne jako inhibitory kinazy wee-1
HRP20180080TT HRP20180080T1 (hr) 2013-12-19 2014-12-19 Pirimidopirimidinoni korisni kao inhibitori wee-1 kinaze
NZ720178A NZ720178A (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
RS20171338A RS56731B1 (sr) 2013-12-19 2014-12-19 Pirimidopirimidinoni korisni kao inhibitori wee-1 kinaze
CN201480069437.9A CN105829315B (zh) 2013-12-19 2014-12-19 可用作Wee-1激酶抑制剂的嘧啶并嘧啶酮类
JP2016541294A JP6437559B2 (ja) 2013-12-19 2014-12-19 Wee−1キナーゼ阻害剤として有用なピリミドピリミジノン
KR1020167019551A KR102405462B1 (ko) 2013-12-19 2014-12-19 Wee-1 카이네이즈 억제제로 유용한 피리미도피리미디논
SI201430580T SI3083625T1 (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones, useful as Wee-1 kinase inhibitors
SM20180020T SMT201800020T1 (it) 2013-12-19 2014-12-19 Pirimidopirimidinoni utili come inibitori della chinasi wee-1
US15/105,869 US9850247B2 (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors
ES14815843.9T ES2650013T3 (es) 2013-12-19 2014-12-19 Pirimidopirimidinonas útiles como inhibidores de la quinasa Wee-1
AU2014369457A AU2014369457B2 (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors
MX2016007801A MX371108B (es) 2013-12-19 2014-12-19 Pirimidopirimidinonas utiles como iniciadores de wee-1 cinasa.
PT148158439T PT3083625T (pt) 2013-12-19 2014-12-19 Pirimidopirimidinonas úteis como inibidores da cinase wee-1
DK14815843.9T DK3083625T3 (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
RU2016123363A RU2691105C1 (ru) 2013-12-19 2014-12-19 Лекарственные соединения
SG11201603814TA SG11201603814TA (en) 2013-12-19 2014-12-19 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
ZA2016/03337A ZA201603337B (en) 2013-12-19 2016-05-17 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
IL245672A IL245672B (en) 2013-12-19 2016-05-17 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors
CY20181100041T CY1120035T1 (el) 2013-12-19 2018-01-15 Πυριμιδοπυριμιδινονες χρησιμες ως αναστολεις της wee-1 κινασης

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1322602.2A GB201322602D0 (en) 2013-12-19 2013-12-19 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
GB201322602D0 true GB201322602D0 (en) 2014-02-05

Family

ID=50071157

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1322602.2A Ceased GB201322602D0 (en) 2013-12-19 2013-12-19 Pharmaceutical compounds

Country Status (28)

Country Link
US (1) US9850247B2 (OSRAM)
EP (1) EP3083625B1 (OSRAM)
JP (1) JP6437559B2 (OSRAM)
KR (1) KR102405462B1 (OSRAM)
CN (1) CN105829315B (OSRAM)
AU (1) AU2014369457B2 (OSRAM)
BR (1) BR112016014151B1 (OSRAM)
CA (1) CA2933755C (OSRAM)
CY (1) CY1120035T1 (OSRAM)
DK (1) DK3083625T3 (OSRAM)
ES (1) ES2650013T3 (OSRAM)
GB (1) GB201322602D0 (OSRAM)
HR (1) HRP20180080T1 (OSRAM)
HU (1) HUE037908T2 (OSRAM)
IL (1) IL245672B (OSRAM)
LT (1) LT3083625T (OSRAM)
MX (1) MX371108B (OSRAM)
NO (1) NO3083625T3 (OSRAM)
NZ (1) NZ720178A (OSRAM)
PL (1) PL3083625T3 (OSRAM)
PT (1) PT3083625T (OSRAM)
RS (1) RS56731B1 (OSRAM)
RU (1) RU2691105C1 (OSRAM)
SG (1) SG11201603814TA (OSRAM)
SI (1) SI3083625T1 (OSRAM)
SM (1) SMT201800020T1 (OSRAM)
WO (1) WO2015092431A1 (OSRAM)
ZA (1) ZA201603337B (OSRAM)

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CN108137593B (zh) * 2015-04-21 2021-01-05 上海交通大学医学院附属瑞金医院 蛋白激酶抑制剂的制备和用途
CA3003737C (en) 2015-11-01 2021-09-14 The Regents Of The University Of Colorado, A Body Corporate Wee1 kinase inhibitors and methods of making and using the same
JP7240784B2 (ja) * 2016-11-16 2023-03-16 上海瑛派▲薬▼▲業▼有限公司 8,9-ジヒドロイミダゾール[1,2-a]ピリミド[5,4-e]ピリミジン-5(6H)-ケトン類化合物
WO2018124001A1 (ja) 2016-12-27 2018-07-05 国立研究開発法人理化学研究所 Bmpシグナル阻害化合物
ES2902050T3 (es) 2017-01-23 2022-03-24 Shijiazhuang Sagacity New Drug Dev Co Ltd Derivado 1,2-dihidro-3H-pirazolo[3,4-D]pirimidin-3-ona como inhibidor de Wee1
GB201703881D0 (en) 2017-03-10 2017-04-26 Almac Discovery Ltd Pharmaceutical compounds
US20200108074A1 (en) 2017-03-31 2020-04-09 Seattle Genetics, Inc. Combinations of chk1- and wee1- inhibitors
WO2019011228A1 (zh) * 2017-07-10 2019-01-17 上海瑛派药业有限公司 咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用
WO2019037678A1 (zh) * 2017-08-24 2019-02-28 上海迪诺医药科技有限公司 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用
WO2019074981A1 (en) 2017-10-09 2019-04-18 GiraFpharma LLC HETEROCYCLIC COMPOUNDS AND USES THEREOF
WO2019074979A1 (en) 2017-10-09 2019-04-18 Girafpharma, Llc HETEROCYCLIC COMPOUNDS AND USES THEREOF
PT3712150T (pt) 2017-11-01 2024-08-22 Wuxi Biocity Biopharmaceutics Co Ltd Composto macrocíclico que serve como inibidor wee1 e aplicações do mesmo
CA3088997A1 (en) 2018-02-28 2019-09-06 The Regents Of The University Of Colorado, A Body Corporate Wee1 kinase inhibitors and methods of treating cancer using the same
WO2020063788A1 (zh) * 2018-09-27 2020-04-02 贝达药业股份有限公司 Fgfr4抑制剂及其应用
JP7481336B2 (ja) 2018-10-26 2024-05-10 ウーシー・バイオシティ・バイオファーマシューティクス・カンパニー・リミテッド Wee1阻害剤としてのピリミドピラゾロン類誘導体及びその使用
US20230065740A1 (en) 2018-12-28 2023-03-02 Spv Therapeutics Inc. Cyclin-dependent kinase inhibitors
JP2022528047A (ja) 2019-03-22 2022-06-08 ショウヤオ ホールディングス(ベイジン) カンパニー, リミテッド Wee1阻害剤、その製造および用途
EP3952878A4 (en) * 2019-04-09 2023-01-04 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND THEIR USES
US20220162229A1 (en) * 2019-04-09 2022-05-26 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
WO2020210375A1 (en) 2019-04-09 2020-10-15 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
US12291536B2 (en) 2019-04-30 2025-05-06 Wuxi Biocity Biopharmaceutics Co., Ltd. Crystal form of Wee1 inhibitor compound and use thereof
CN112142763B (zh) * 2019-06-28 2024-01-26 上海医药集团股份有限公司 一种吡唑酮并嘧啶类化合物、其制备方法及应用
US12522607B2 (en) 2020-06-17 2026-01-13 Wigen Biomedicine Technology (shanghai) Co., Ltd. Substituted pyrazolo[3,4-d]pyrimidines as wee-1 inhibitors
US20230416247A1 (en) * 2020-10-01 2023-12-28 University Of Washington Drug-like molecules and methods for the therapeutic targeting of microrna-21
US12551584B1 (en) 2020-12-07 2026-02-17 Actinium Pharmaceuticals, Inc. Lewis Y radioimmunotherapy for the treatment of cancer
CA3202328A1 (en) * 2020-12-18 2022-06-23 Jie GUANG Chemical compounds useful for inhibiting nav1.8 voltage-gated sodium channels and treating nav1.8 mediated diseases
TW202239409A (zh) * 2020-12-18 2022-10-16 英商葛蘭素史密斯克藍智慧財產發展有限公司 化合物
EP4332104A4 (en) 2021-04-30 2025-04-16 Wigen Biomedicine Technology (Shanghai) Co., Ltd. Fused ring compound as a WEE-1 inhibitor, as well as production process and use thereof
WO2022270994A1 (ko) 2021-06-25 2022-12-29 한국화학연구원 유비퀴틴 프로테오좀 경로를 통해 비티케이 분해작용을 가지는 신규한 이작용성 헤테로사이클릭 화합물과 이의 용도
CN116462687B (zh) 2022-01-18 2025-01-07 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
CN116836184B (zh) * 2022-03-25 2025-07-25 药雅科技(上海)有限公司 Wee1激酶抑制剂的制备及其应用
WO2023217201A2 (zh) * 2022-05-10 2023-11-16 杭州德睿智药科技有限公司 作为Wee1抑制剂的新型嘧啶并杂环类新化合物及其应用
CN117402162A (zh) 2022-07-13 2024-01-16 江苏天士力帝益药业有限公司 Wee1抑制剂及其制备和用途
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Also Published As

Publication number Publication date
CY1120035T1 (el) 2018-12-12
PL3083625T3 (pl) 2018-03-30
SMT201800020T1 (it) 2018-05-02
BR112016014151A2 (OSRAM) 2017-08-08
US9850247B2 (en) 2017-12-26
HUE037908T2 (hu) 2018-09-28
CA2933755A1 (en) 2015-06-25
IL245672A0 (en) 2016-06-30
MX371108B (es) 2020-01-17
CN105829315A (zh) 2016-08-03
LT3083625T (lt) 2017-12-27
ZA201603337B (en) 2018-07-25
KR20160098499A (ko) 2016-08-18
EP3083625B1 (en) 2017-11-01
AU2014369457B2 (en) 2018-08-09
RU2691105C1 (ru) 2019-06-11
NZ720178A (en) 2022-05-27
JP2017500335A (ja) 2017-01-05
NO3083625T3 (OSRAM) 2018-03-31
HRP20180080T1 (hr) 2018-03-09
CN105829315B (zh) 2019-03-08
BR112016014151B1 (pt) 2023-01-17
RU2016123363A (ru) 2018-01-25
KR102405462B1 (ko) 2022-06-03
EP3083625A1 (en) 2016-10-26
IL245672B (en) 2021-10-31
PT3083625T (pt) 2018-02-06
SG11201603814TA (en) 2016-07-28
DK3083625T3 (en) 2017-12-18
AU2014369457A1 (en) 2016-06-09
US20160318936A1 (en) 2016-11-03
CA2933755C (en) 2023-01-31
JP6437559B2 (ja) 2018-12-12
WO2015092431A1 (en) 2015-06-25
MX2016007801A (es) 2016-09-07
SI3083625T1 (en) 2018-03-30
RS56731B1 (sr) 2018-03-30
ES2650013T3 (es) 2018-01-16

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