GB201116559D0 - Novel viral replication inhibitors - Google Patents

Novel viral replication inhibitors

Info

Publication number
GB201116559D0
GB201116559D0 GBGB1116559.4A GB201116559A GB201116559D0 GB 201116559 D0 GB201116559 D0 GB 201116559D0 GB 201116559 A GB201116559 A GB 201116559A GB 201116559 D0 GB201116559 D0 GB 201116559D0
Authority
GB
United Kingdom
Prior art keywords
viral replication
replication inhibitors
novel viral
novel
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1116559.4A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Original Assignee
Katholieke Universiteit Leuven
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44993373&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB201116559(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Katholieke Universiteit Leuven filed Critical Katholieke Universiteit Leuven
Priority to GBGB1116559.4A priority Critical patent/GB201116559D0/en
Publication of GB201116559D0 publication Critical patent/GB201116559D0/en
Priority to MEP-2019-294A priority patent/ME03605B/me
Priority to EP12775463.8A priority patent/EP2760831B1/en
Priority to LT12775463T priority patent/LT2760831T/lt
Priority to PT127754638T priority patent/PT2760831T/pt
Priority to JP2014531279A priority patent/JP6266521B2/ja
Priority to MX2014003585A priority patent/MX355722B/es
Priority to SG10201705974PA priority patent/SG10201705974PA/en
Priority to AU2012314498A priority patent/AU2012314498B2/en
Priority to NZ755313A priority patent/NZ755313B2/en
Priority to CN201280057716.4A priority patent/CN104024223B/zh
Priority to BR112014007134-9A priority patent/BR112014007134B1/pt
Priority to CN201810458919.3A priority patent/CN108440370B/zh
Priority to AP2014007535A priority patent/AP2014070535A0/xx
Priority to RSP20191312 priority patent/RS59404B1/sr
Priority to SG11201400927WA priority patent/SG11201400927WA/en
Priority to EP19183201.3A priority patent/EP3617192A1/en
Priority to PL12775463T priority patent/PL2760831T3/pl
Priority to EA201490654A priority patent/EA032477B1/ru
Priority to US14/346,777 priority patent/US10550123B2/en
Priority to MYPI2019002388A priority patent/MY202109A/en
Priority to NZ622588A priority patent/NZ622588B2/en
Priority to PE2014000413A priority patent/PE20141280A1/es
Priority to NZ739958A priority patent/NZ739958B2/en
Priority to PCT/EP2012/069007 priority patent/WO2013045516A1/en
Priority to ES12775463T priority patent/ES2753966T3/es
Priority to UAA201404302A priority patent/UA115537C2/uk
Priority to KR1020147010538A priority patent/KR102081444B1/ko
Priority to HUE12775463A priority patent/HUE046540T2/hu
Priority to KR1020197020675A priority patent/KR102204695B1/ko
Priority to MYPI2014000873A priority patent/MY182771A/en
Priority to SI201231674T priority patent/SI2760831T1/sl
Priority to CA2848604A priority patent/CA2848604C/en
Priority to DK12775463.8T priority patent/DK2760831T3/da
Priority to UAA201708276A priority patent/UA125790C2/uk
Priority to ZA2014/01665A priority patent/ZA201401665B/en
Priority to IL231492A priority patent/IL231492B/en
Priority to NI201400025A priority patent/NI201400025A/es
Priority to CL2014000732A priority patent/CL2014000732A1/es
Priority to GT201400053A priority patent/GT201400053A/es
Priority to CR20140147A priority patent/CR20140147A/es
Priority to ECSP14013315 priority patent/ECSP14013315A/es
Priority to CO14089597A priority patent/CO7010824A2/es
Priority to CL2016001580A priority patent/CL2016001580A1/es
Priority to AU2017221865A priority patent/AU2017221865B2/en
Priority to JP2017243354A priority patent/JP6906437B2/ja
Priority to US16/515,272 priority patent/US11279704B2/en
Priority to IL268366A priority patent/IL268366B2/en
Priority to PH12019501907A priority patent/PH12019501907A1/en
Priority to AU2019219850A priority patent/AU2019219850B2/en
Priority to HRP20191857TT priority patent/HRP20191857T1/hr
Priority to CY20191101094T priority patent/CY1122291T1/el
Priority to US17/538,532 priority patent/US20220106321A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
GBGB1116559.4A 2011-09-26 2011-09-26 Novel viral replication inhibitors Ceased GB201116559D0 (en)

Priority Applications (53)

Application Number Priority Date Filing Date Title
GBGB1116559.4A GB201116559D0 (en) 2011-09-26 2011-09-26 Novel viral replication inhibitors
MEP-2019-294A ME03605B (me) 2011-09-26 2012-09-26 Inhibitori virusne replikacije
EP12775463.8A EP2760831B1 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
LT12775463T LT2760831T (lt) 2011-09-26 2012-09-26 Viruso replikacijos slopikliai
PT127754638T PT2760831T (pt) 2011-09-26 2012-09-26 Inibidores da replicação viral
JP2014531279A JP6266521B2 (ja) 2011-09-26 2012-09-26 ウイルス複製阻害剤
MX2014003585A MX355722B (es) 2011-09-26 2012-09-26 Nuevos inhibidores de aplicacion viral.
SG10201705974PA SG10201705974PA (en) 2011-09-26 2012-09-26 Viral replication inhibitors
AU2012314498A AU2012314498B2 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
NZ755313A NZ755313B2 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
CN201280057716.4A CN104024223B (zh) 2011-09-26 2012-09-26 病毒复制抑制剂
BR112014007134-9A BR112014007134B1 (pt) 2011-09-26 2012-09-26 Usos de um composto da fórmula (b), compostos, composição farmacêutica, método de preparação do composto e uso do composto para fabricação de um medicamento para tratar ou prevenir infecções flavivirais
CN201810458919.3A CN108440370B (zh) 2011-09-26 2012-09-26 病毒复制抑制剂
AP2014007535A AP2014070535A0 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
RSP20191312 RS59404B1 (sr) 2011-09-26 2012-09-26 Inhibitori virusne replikacije
SG11201400927WA SG11201400927WA (en) 2011-09-26 2012-09-26 Viral replication inhibitors
EP19183201.3A EP3617192A1 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
PL12775463T PL2760831T3 (pl) 2011-09-26 2012-09-26 Inhibitory replikacji wirusa
EA201490654A EA032477B1 (ru) 2011-09-26 2012-09-26 Ингибиторы вирусной репликации
US14/346,777 US10550123B2 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
MYPI2019002388A MY202109A (en) 2011-09-26 2012-09-26 Viral replication inhibitors
NZ622588A NZ622588B2 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
PE2014000413A PE20141280A1 (es) 2011-09-26 2012-09-26 Inhibidores de aplicacion viral
NZ739958A NZ739958B2 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
PCT/EP2012/069007 WO2013045516A1 (en) 2011-09-26 2012-09-26 Viral replication inhibitors
ES12775463T ES2753966T3 (es) 2011-09-26 2012-09-26 Inhibidores de replicación viral
UAA201404302A UA115537C2 (uk) 2011-09-26 2012-09-26 Інгібітори вірусної реплікації
KR1020147010538A KR102081444B1 (ko) 2011-09-26 2012-09-26 신규의 바이러스 복제 저해제
HUE12775463A HUE046540T2 (hu) 2011-09-26 2012-09-26 Vírusreplikáció-gátló szerek
KR1020197020675A KR102204695B1 (ko) 2011-09-26 2012-09-26 신규의 바이러스 복제 저해제
MYPI2014000873A MY182771A (en) 2011-09-26 2012-09-26 Viral replication inhibitors
SI201231674T SI2760831T1 (sl) 2011-09-26 2012-09-26 Inhibitorji replikacije virusov
CA2848604A CA2848604C (en) 2011-09-26 2012-09-26 Viral replication inhibitors
DK12775463.8T DK2760831T3 (da) 2011-09-26 2012-09-26 Inhibitorer af virusreplikation
UAA201708276A UA125790C2 (uk) 2011-09-26 2012-09-26 Інгібітори вірусної реплікації
ZA2014/01665A ZA201401665B (en) 2011-09-26 2014-03-06 Viral replication inhibitors
IL231492A IL231492B (en) 2011-09-26 2014-03-12 Inhibitors of viral replication
NI201400025A NI201400025A (es) 2011-09-26 2014-03-25 Inhibidores de aplicación viral
CL2014000732A CL2014000732A1 (es) 2011-09-26 2014-03-25 Compuestos derivados heterociclicos para su uso en la prevencion o tratamiento de una infeccion por flavivirus; metodo para su preparacion; y composicion farmaceutica que los comprende.
GT201400053A GT201400053A (es) 2011-09-26 2014-03-26 Inhibidores de aplicación viral
CR20140147A CR20140147A (es) 2011-09-26 2014-04-01 Inhibidores de aplicación viral
ECSP14013315 ECSP14013315A (es) 2011-09-26 2014-04-16 Inhibidores de aplicación viral
CO14089597A CO7010824A2 (es) 2011-09-26 2014-04-28 Inhibidores de aplicación viral
CL2016001580A CL2016001580A1 (es) 2011-09-26 2016-06-17 Uso de compuestos derivados de indol para tratar una infección por flavivirus; compuestos derivados de indol; composiciones farmacéuticas; y uso de una combinación.
AU2017221865A AU2017221865B2 (en) 2011-09-26 2017-09-01 Viral replication inhibitors
JP2017243354A JP6906437B2 (ja) 2011-09-26 2017-12-20 ウイルス複製阻害剤
US16/515,272 US11279704B2 (en) 2011-09-26 2019-07-18 Viral replication inhibitors
IL268366A IL268366B2 (en) 2011-09-26 2019-07-30 Inhibitors of viral replication
PH12019501907A PH12019501907A1 (en) 2011-09-26 2019-08-16 Novel viral replication inhibitors
AU2019219850A AU2019219850B2 (en) 2011-09-26 2019-08-23 Viral replication inhibitors
HRP20191857TT HRP20191857T1 (hr) 2011-09-26 2019-10-15 Inhibitori replikacije virusa
CY20191101094T CY1122291T1 (el) 2011-09-26 2019-10-21 Αναστολeις ιικου αναδιπλασιασμου
US17/538,532 US20220106321A1 (en) 2011-09-26 2021-11-30 Viral replication inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1116559.4A GB201116559D0 (en) 2011-09-26 2011-09-26 Novel viral replication inhibitors

Publications (1)

Publication Number Publication Date
GB201116559D0 true GB201116559D0 (en) 2011-11-09

Family

ID=44993373

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1116559.4A Ceased GB201116559D0 (en) 2011-09-26 2011-09-26 Novel viral replication inhibitors

Country Status (34)

Country Link
US (3) US10550123B2 (xx)
EP (2) EP3617192A1 (xx)
JP (2) JP6266521B2 (xx)
KR (2) KR102204695B1 (xx)
CN (2) CN104024223B (xx)
AP (1) AP2014070535A0 (xx)
AU (3) AU2012314498B2 (xx)
BR (1) BR112014007134B1 (xx)
CA (1) CA2848604C (xx)
CL (2) CL2014000732A1 (xx)
CO (1) CO7010824A2 (xx)
CR (1) CR20140147A (xx)
CY (1) CY1122291T1 (xx)
DK (1) DK2760831T3 (xx)
EA (1) EA032477B1 (xx)
EC (1) ECSP14013315A (xx)
ES (1) ES2753966T3 (xx)
GB (1) GB201116559D0 (xx)
GT (1) GT201400053A (xx)
HR (1) HRP20191857T1 (xx)
HU (1) HUE046540T2 (xx)
IL (2) IL231492B (xx)
LT (1) LT2760831T (xx)
ME (1) ME03605B (xx)
MX (1) MX355722B (xx)
MY (2) MY182771A (xx)
PE (1) PE20141280A1 (xx)
PL (1) PL2760831T3 (xx)
PT (1) PT2760831T (xx)
RS (1) RS59404B1 (xx)
SG (2) SG11201400927WA (xx)
SI (1) SI2760831T1 (xx)
UA (2) UA115537C2 (xx)
WO (1) WO2013045516A1 (xx)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
CN105130948A (zh) 2010-04-22 2015-12-09 弗特克斯药品有限公司 制备环烷基甲酰胺基-吲哚化合物的方法
GB201116559D0 (en) * 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
RS57476B9 (sr) 2014-04-15 2021-10-29 Vertex Pharma Farmaceutske kompozicije za lečenje bolesti posredovanih transmembranskim regulatorom provodljivosti cistične fibroze
PT3201176T (pt) * 2014-10-01 2019-03-04 Janssen Pharmaceuticals Inc Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue
KR102478309B1 (ko) * 2014-10-01 2022-12-15 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 １치환 또는 ２치환 인돌
CN105503763B (zh) * 2014-10-17 2020-11-03 上海中科康润新材料科技有限公司 聚烯烃油催化剂及其应用
JOP20150335B1 (ar) * 2015-01-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
WO2016172496A1 (en) 2015-04-23 2016-10-27 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and uses thereof
JOP20160086B1 (ar) * 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) * 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CR20180495A (es) * 2016-03-31 2018-12-06 Univ Leuven Kath Deribados de indol sustituidos como inhibidores de replicación viral del dengue
BR112018069601A2 (pt) 2016-03-31 2019-01-29 Janssen Pharmaceuticals Inc derivados de indolina substituídos como inibidores da replicação viral da dengue
MA44502A (fr) 2016-04-01 2019-02-06 Janssen Pharmaceuticals Inc Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue
JOP20170069B1 (ar) * 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JP6983813B2 (ja) * 2016-04-28 2021-12-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft ２−ピラゾロ［１，５−ａ］ピラジン−２−イルピリド［１，２−ａ］ピリミジン−４−オンの調製のためのプロセス
EP3532459B1 (en) 2016-10-26 2023-08-02 Constellation Pharmaceuticals, Inc. Lsd1 inhibitors and medical uses thereof
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) * 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR102625988B1 (ko) 2017-05-22 2024-01-16 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체
IL270727B2 (en) * 2017-05-22 2023-03-01 Janssen Pharmaceuticals Inc Transduced indulin derivatives as inhibitors of dengue virus replication
WO2019161157A1 (en) 2018-02-16 2019-08-22 Constellation Pharmceuticals, Inc. P300/cbp hat inhibitors
CN112218857B (zh) 2018-02-16 2023-11-21 星座制药公司 P300/cbp hat抑制剂及其使用方法

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5543523A (en) 1994-11-15 1996-08-06 Regents Of The University Of Minnesota Method and intermediates for the synthesis of korupensamines
AU2001239791A1 (en) 2000-02-17 2001-08-27 Du Pont Pharmaceuticals Company Succinoylamino carbocycles and heterocycles as inhibitors of abeta protein production
GB0110832D0 (en) 2001-05-03 2001-06-27 Virogen Ltd Antiviral compounds
CA2468202A1 (en) 2001-12-12 2003-06-19 Conforma Therapeutics Corporation Assays and implements for determining and modulating hsp90 binding activity
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
AU2005228894B9 (en) 2004-03-30 2011-10-13 Intermune, Inc. Macrocyclic compounds as inhibitors of viral replication
CN1938311A (zh) * 2004-03-30 2007-03-28 因特蒙公司 作为病毒复制抑制剂的大环化合物
BRPI0519355A2 (pt) 2004-12-23 2009-01-20 Novartis Ag compostos para tratamento contra flaviviridae
AU2006204917A1 (en) 2005-01-14 2006-07-20 Smithkline Beecham Corporation Indole derivatives for treating viral infections
EP1853317A2 (en) 2005-02-09 2007-11-14 Migenix Inc. Compositions and methods for treating or preventing flaviviridae infections
DE102005028845A1 (de) * 2005-06-22 2006-12-28 Sanofi-Aventis Deutschland Gmbh Substituierte Heterocyclen, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
WO2007017093A1 (en) 2005-08-04 2007-02-15 Bayer Healthcare Ag Substituted 2-benzyloxy-benzoic acid amide derivatives
KR20080040027A (ko) * 2005-09-02 2008-05-07 아스테라스 세이야쿠 가부시키가이샤 Ｒｏｃｋ 억제제로서 아미드 유도체
US8329159B2 (en) * 2006-08-11 2012-12-11 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2183217A2 (en) 2007-07-25 2010-05-12 Boehringer Ingelheim International GmbH Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US9029376B2 (en) 2008-06-03 2015-05-12 Siga Technologies, Inc. Small molecule inhibitors for the treatment or prevention of dengue virus infection
US8543331B2 (en) * 2008-07-03 2013-09-24 Hewlett-Packard Development Company, L.P. Apparatus, and associated method, for planning and displaying a route path
WO2010021878A1 (en) * 2008-08-19 2010-02-25 Janssen Pharmaceutica Nv Cold menthol receptor antagonists
TWI453207B (zh) 2008-09-08 2014-09-21 Signal Pharm Llc 胺基三唑并吡啶，其組合物及使用其之治療方法
EP2393359A4 (en) * 2009-02-09 2012-10-03 Enanta Pharm Inc COMPOUND DIBENZIMIDAZOLE DERIVATIVES
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
US8993604B2 (en) 2009-06-30 2015-03-31 Siga Technologies, Inc. Treatment and prevention of dengue virus infections
JP2012533569A (ja) * 2009-07-16 2012-12-27 ヴァーテックス ファーマシューティカルズ、 インコーポレイテッド フラビウイルス感染症を治療又は予防するためのベンゾイミダゾール類似体
ES2559437T3 (es) 2009-09-09 2016-02-12 Gilead Sciences, Inc. Inhibidores de virus de la familia Flaviviridae
US8524764B2 (en) 2010-01-15 2013-09-03 Gilead Sciences, Inc. Inhibitors of Flaviviridae viruses
GB201116559D0 (en) 2011-09-26 2011-11-09 Univ Leuven Kath Novel viral replication inhibitors
GB201305376D0 (en) 2013-03-25 2013-05-08 Univ Leuven Kath Novel viral replication inhibitors
KR102290189B1 (ko) 2013-10-23 2021-08-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 카르복스아미드 유도체 및 ｂ형 간염 치료용 의약으로서의 이의 용도
MX2016009230A (es) 2014-01-31 2016-10-03 Bristol Myers Squibb Co Macrociclicos con grupos p2'heterociclicos como inhibidores del factor xia.
KR102478309B1 (ko) 2014-10-01 2022-12-15 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 １치환 또는 ２치환 인돌
PT3201176T (pt) 2014-10-01 2019-03-04 Janssen Pharmaceuticals Inc Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue
NO2721243T3 (xx) 2014-10-01 2018-10-20
JOP20150335B1 (ar) 2015-01-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
AR103680A1 (es) 2015-02-23 2017-05-24 Lilly Co Eli Inhibidores selectivos de bace1
JOP20160086B1 (ar) 2015-05-08 2021-08-17 2 Katholieke Univ Leuven Ku Leuven Research And Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar) 2015-09-16 2020-08-27 Katholieke Univ Leuven Ku Leuven Research & Development مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar) 2015-09-16 2022-03-14 Janssen Pharmaceuticals Inc مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
AU2016350868B2 (en) 2015-11-03 2022-03-31 Zoetis Services Llc Sol-gel polymer composites and uses thereof
CR20180495A (es) 2016-03-31 2018-12-06 Univ Leuven Kath Deribados de indol sustituidos como inhibidores de replicación viral del dengue
AU2017245125B2 (en) 2016-03-31 2020-10-22 Takeda Pharmaceutical Company Limited Heterocyclic compound
BR112018069601A2 (pt) 2016-03-31 2019-01-29 Janssen Pharmaceuticals Inc derivados de indolina substituídos como inibidores da replicação viral da dengue
KR102120815B1 (ko) 2016-04-01 2020-06-12 카이트 파마 인코포레이티드 키메라 수용체 및 그의 사용 방법
MA44502A (fr) 2016-04-01 2019-02-06 Janssen Pharmaceuticals Inc Dérivés d'indole substitués utilisés en tant qu'inhibiteurs de réplication du virus de la dengue
EA039392B1 (ru) 2016-04-01 2022-01-21 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Способ лечения рака с применением замещенного аминопуринового соединения
PL3436079T3 (pl) 2016-04-01 2021-12-20 Kite Pharma, Inc. Antygen chimeryczny i receptory komórek t oraz sposoby ich stosowania
WO2017173410A1 (en) 2016-04-01 2017-10-05 Amgen Inc. Chimeric receptors to flt3 and methods of use thereof
JOP20170069B1 (ar) 2016-04-01 2021-08-17 1 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CN108779121A (zh) 2016-04-01 2018-11-09 巴斯夫欧洲公司 双环化合物
JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar) 2017-03-31 2021-08-17 Janssen Pharmaceuticals Inc مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
IL270727B2 (en) 2017-05-22 2023-03-01 Janssen Pharmaceuticals Inc Transduced indulin derivatives as inhibitors of dengue virus replication
KR102625988B1 (ko) 2017-05-22 2024-01-16 얀센 파마슈티칼즈, 인코포레이티드 뎅기 바이러스 복제 억제제로서의 치환 인돌린 유도체

Also Published As

Publication number Publication date
GT201400053A (es) 2018-12-19
ES2753966T3 (es) 2020-04-15
NZ755313A (en) 2021-04-30
PE20141280A1 (es) 2014-10-03
KR20190087659A (ko) 2019-07-24
MY182771A (en) 2021-02-05
NZ622588A (en) 2017-01-27
AP2014070535A0 (en) 2014-03-31
PL2760831T3 (pl) 2020-01-31
HUE046540T2 (hu) 2020-03-30
KR102081444B1 (ko) 2020-04-17
EP2760831A1 (en) 2014-08-06
MY202109A (en) 2024-04-04
KR102204695B1 (ko) 2021-01-20
US11279704B2 (en) 2022-03-22
AU2019219850A1 (en) 2019-09-12
UA125790C2 (uk) 2022-06-08
US20140213586A1 (en) 2014-07-31
BR112014007134A2 (pt) 2017-12-19
BR112014007134B1 (pt) 2022-01-04
JP2018095646A (ja) 2018-06-21
AU2012314498B2 (en) 2017-09-21
JP2014527978A (ja) 2014-10-23
JP6266521B2 (ja) 2018-01-24
MX2014003585A (es) 2014-04-10
CN104024223A (zh) 2014-09-03
EP3617192A1 (en) 2020-03-04
CR20140147A (es) 2014-08-04
CN104024223B (zh) 2018-07-24
ME03605B (me) 2020-07-20
CN108440370B (zh) 2021-07-30
US20190337954A1 (en) 2019-11-07
CA2848604A1 (en) 2013-04-04
IL231492B (en) 2019-08-29
SI2760831T1 (sl) 2019-11-29
JP6906437B2 (ja) 2021-07-21
RS59404B1 (sr) 2019-11-29
CL2016001580A1 (es) 2017-01-13
EP2760831B1 (en) 2019-08-07
LT2760831T (lt) 2019-10-25
EA201490654A1 (ru) 2014-11-28
HRP20191857T1 (hr) 2019-12-27
SG10201705974PA (en) 2017-08-30
AU2012314498A1 (en) 2014-04-03
CO7010824A2 (es) 2014-07-31
AU2017221865B2 (en) 2019-09-12
CN108440370A (zh) 2018-08-24
CY1122291T1 (el) 2021-01-27
AU2019219850B2 (en) 2021-03-04
DK2760831T3 (da) 2019-10-21
CL2014000732A1 (es) 2014-09-26
CA2848604C (en) 2022-09-13
IL268366A (en) 2019-09-26
US20220106321A1 (en) 2022-04-07
IL268366B1 (en) 2023-01-01
US10550123B2 (en) 2020-02-04
SG11201400927WA (en) 2014-04-28
PT2760831T (pt) 2019-10-29
IL268366B2 (en) 2023-05-01
AU2017221865A1 (en) 2017-09-21
IL231492A0 (en) 2014-04-30
UA115537C2 (uk) 2017-11-27
ECSP14013315A (es) 2014-06-30
MX355722B (es) 2018-04-27
KR20140069209A (ko) 2014-06-09
EA032477B1 (ru) 2019-06-28
WO2013045516A1 (en) 2013-04-04

Similar Documents

Publication Publication Date Title
IL268366A (en) Inhibitors of viral replication
HK1200828A1 (en) Kinase inhibitors
EP2683693A4 (en) ROR-GAMMA-T INHIBITORS
EP2734529A4 (en) BTK INHIBITORS
EP2772480A4 (en) HIV REPLICATION INHIBITORS
PL2710007T3 (pl) Inhibitory kinazy
GB0908394D0 (en) Novel viral replication inhibitors
GB0913636D0 (en) Novel viral replication inhibitors
IL229028A0 (en) Kinase inhibitors
HK1199873A1 (en) Kinase inhibitors
IL231132A0 (en) Viral cleaning methods
IL231269B (en) Preparations for the treatment of HIV
EP2776393A4 (en) NAMPT INHIBITORS
ZA201401330B (en) Hiv replication inhibitors
EP2663574A4 (en) RETRO VIRUS REPLICATION INHIBITORS
EP2755663A4 (en) INHIBITORS OF MICRO-ARNMICRORNA INHIBITORS
ZA201401665B (en) Viral replication inhibitors
GB201114891D0 (en) Novel viral replication inhibitors
GB201104399D0 (en) Novel inhibitors
GB201120474D0 (en) Inhibitors
GB201115259D0 (en) Half-barrel side-planter

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)