GB1515540A - 4-amino-trans-decahydroquinoline derivatives - Google Patents
4-amino-trans-decahydroquinoline derivativesInfo
- Publication number
- GB1515540A GB1515540A GB51507/75A GB5150775A GB1515540A GB 1515540 A GB1515540 A GB 1515540A GB 51507/75 A GB51507/75 A GB 51507/75A GB 5150775 A GB5150775 A GB 5150775A GB 1515540 A GB1515540 A GB 1515540A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- carbonyl
- alkyl
- reacting
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 3
- -1 hydroxyiminomethylene Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VZTBFFGJFFYFRT-HTQZYQBOSA-N (4ar,8ar)-2,3,4a,5,6,7,8,8a-octahydro-1h-quinolin-4-one Chemical compound C1CCC[C@H]2C(=O)CCN[C@@H]21 VZTBFFGJFFYFRT-HTQZYQBOSA-N 0.000 abstract 1
- POTIYWUALSJREP-DTWKUNHWSA-N (4as,8ar)-1,2,3,4,4a,5,6,7,8,8a-decahydroquinoline Chemical class N1CCC[C@@H]2CCCC[C@H]21 POTIYWUALSJREP-DTWKUNHWSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Priority Applications (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51507/75A GB1515540A (en) | 1975-12-16 | 1975-12-16 | 4-amino-trans-decahydroquinoline derivatives |
| IE2613/76A IE44355B1 (en) | 1975-12-16 | 1976-11-26 | 4-amino-trans-decahydroquinoline derivatives |
| ZA00767112A ZA767112B (en) | 1975-12-16 | 1976-11-29 | Heterocyclic compounds and processes for preparing the same |
| NZ182758A NZ182758A (en) | 1975-12-16 | 1976-11-29 | 1-substituled-4(n-acyl-n-substituted amino) -trans-decahyclroiso-quinolines (forms a or b) |
| AU20328/76A AU509897B2 (en) | 1975-12-16 | 1976-12-07 | 4-amino-trans-decahydroquinoline derivatives |
| NL7613629A NL7613629A (nl) | 1975-12-16 | 1976-12-08 | Werkwijze voor de bereiding van 4-amino-trans- -decahydrochinolinederivaten. |
| AR265813A AR214988A1 (es) | 1975-12-16 | 1976-12-13 | Un procedimiento para preparar derivados 1-sustituido-4-amino sustituidos de decahidroquinolina |
| CA267,706A CA1077040A (en) | 1975-12-16 | 1976-12-13 | Pharmaceutically active decahydroquinoline derivatives |
| CH1565976A CH618970A5 (en) | 1975-12-16 | 1976-12-13 | Process for the preparation of 4-amido-trans-decahydroquinoline derivatives |
| FR7637621A FR2335224A1 (fr) | 1975-12-16 | 1976-12-14 | Nouveaux derives de decahydroquinoleine, leurs procedes de preparation ainsi que les compositions therapeutiques les contenant |
| MX765223A MX5798E (es) | 1975-12-16 | 1976-12-14 | Procedimiento para la preparacion de derivados de 4-amino-trans-decahidroquinolina |
| OA56017A OA05515A (fr) | 1975-12-16 | 1976-12-15 | Procédé de préparation de nouveaux dérivés de décahydroquinoléine. |
| SU762428755A SU633476A3 (ru) | 1975-12-16 | 1976-12-15 | Способ получени производных 4-амино-транс-декагидрохинолина или их солей |
| BE173281A BE849431A (fr) | 1975-12-16 | 1976-12-15 | Nouveaux derives de decahydroquinoleine, leurs preparations de preparation ainsi que les compositions therapeutiques les contenant |
| DK564876A DK564876A (da) | 1975-12-16 | 1976-12-15 | Heterocycliske forbindelser og fremgangsmade til fremstilling deraf |
| FI763603A FI63023C (fi) | 1975-12-16 | 1976-12-15 | Foerfarande foer framstaellning av smaertlindrande 4-amino-trans-dekahydrokinolinderivat |
| SE7614105A SE434396B (sv) | 1975-12-16 | 1976-12-15 | Analogiforfarande for framstellning av 4-amino-transdekahydrokinolinderivat |
| IT30441/76A IT1065969B (it) | 1975-12-16 | 1976-12-15 | Composti eterociclici e procedimenti per preparare gli stessi |
| HU76LA900A HU175391B (hu) | 1975-12-16 | 1976-12-15 | Sposob poluchenija proizvodnykh 4-amino-trans-dekagidrokinolina i farmacevticheskikh kompozicijj soderzhahhikh ikh aktivnymi agentami |
| DD7600196381A DD128709A5 (de) | 1975-12-16 | 1976-12-15 | Verfahren zur herstellung von dekahydrochinolinderivaten |
| JP51151456A JPS6022711B2 (ja) | 1975-12-16 | 1976-12-15 | トランス−デカハイドロキノリン誘導体，その製造法，及びそれを含む医薬 |
| NO764251A NO145916C (no) | 1975-12-16 | 1976-12-15 | Analogifremgangsmaate for fremstilling av farmakologisk aktive 4-amino-trans-dekahydrokinolin-derivater |
| DE2656678A DE2656678C2 (de) | 1975-12-16 | 1976-12-15 | 4-Amino-trans-decahydrochinolin-Derivate und Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
| PT65970A PT65970B (fr) | 1975-12-16 | 1976-12-15 | Procede pour la preparation d'une composition pharmaceutique |
| YU3071/76A YU39980B (en) | 1975-12-16 | 1976-12-16 | Process for obtaining 4-amino-trans-decahydroquinoline derivatives |
| ES454285A ES454285A1 (es) | 1975-12-16 | 1976-12-16 | Procedimiento para preparar derivados de 4-amina trans-deca-hidroquinolina. |
| AT932076A AT357535B (de) | 1975-12-16 | 1976-12-16 | Verfahren zur herstellung von neuen 4-amino- transdecahydrochinolinderivaten und ihren saeureadditionssalzen |
| PL1976194452A PL101143B1 (pl) | 1975-12-16 | 1976-12-16 | Sposob wytwarzania pochodnych 4-amino-trans-dekahydrochinoliny |
| US05/884,705 US4173636A (en) | 1975-12-16 | 1978-03-08 | Decahydroquinolines, pharmaceutical compositions and methods of use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB51507/75A GB1515540A (en) | 1975-12-16 | 1975-12-16 | 4-amino-trans-decahydroquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1515540A true GB1515540A (en) | 1978-06-28 |
Family
ID=10460296
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB51507/75A Expired GB1515540A (en) | 1975-12-16 | 1975-12-16 | 4-amino-trans-decahydroquinoline derivatives |
Country Status (28)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005097806A1 (en) * | 2004-03-26 | 2005-10-20 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2592879B1 (fr) * | 1986-01-13 | 1988-04-29 | Roussel Uclaf | Nouveaux derives de la decahydroquinoleine, leur procede de preparation, les intermediaires de preparation, leur application a titre de medicaments et les compositions les renfermant |
-
1975
- 1975-12-16 GB GB51507/75A patent/GB1515540A/en not_active Expired
-
1976
- 1976-11-26 IE IE2613/76A patent/IE44355B1/en unknown
- 1976-11-29 ZA ZA00767112A patent/ZA767112B/xx unknown
- 1976-11-29 NZ NZ182758A patent/NZ182758A/xx unknown
- 1976-12-07 AU AU20328/76A patent/AU509897B2/en not_active Expired
- 1976-12-08 NL NL7613629A patent/NL7613629A/xx not_active Application Discontinuation
- 1976-12-13 AR AR265813A patent/AR214988A1/es active
- 1976-12-13 CH CH1565976A patent/CH618970A5/fr not_active IP Right Cessation
- 1976-12-13 CA CA267,706A patent/CA1077040A/en not_active Expired
- 1976-12-14 MX MX765223A patent/MX5798E/es unknown
- 1976-12-14 FR FR7637621A patent/FR2335224A1/fr active Granted
- 1976-12-15 HU HU76LA900A patent/HU175391B/hu unknown
- 1976-12-15 DE DE2656678A patent/DE2656678C2/de not_active Expired
- 1976-12-15 PT PT65970A patent/PT65970B/pt unknown
- 1976-12-15 JP JP51151456A patent/JPS6022711B2/ja not_active Expired
- 1976-12-15 FI FI763603A patent/FI63023C/fi not_active IP Right Cessation
- 1976-12-15 OA OA56017A patent/OA05515A/xx unknown
- 1976-12-15 SE SE7614105A patent/SE434396B/xx not_active IP Right Cessation
- 1976-12-15 NO NO764251A patent/NO145916C/no unknown
- 1976-12-15 DD DD7600196381A patent/DD128709A5/xx unknown
- 1976-12-15 IT IT30441/76A patent/IT1065969B/it active
- 1976-12-15 SU SU762428755A patent/SU633476A3/ru active
- 1976-12-15 BE BE173281A patent/BE849431A/xx not_active IP Right Cessation
- 1976-12-15 DK DK564876A patent/DK564876A/da not_active Application Discontinuation
- 1976-12-16 AT AT932076A patent/AT357535B/de not_active IP Right Cessation
- 1976-12-16 YU YU3071/76A patent/YU39980B/xx unknown
- 1976-12-16 PL PL1976194452A patent/PL101143B1/pl unknown
- 1976-12-16 ES ES454285A patent/ES454285A1/es not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005097806A1 (en) * | 2004-03-26 | 2005-10-20 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
| US7470705B2 (en) | 2004-03-26 | 2008-12-30 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |