GB1496874A - 5-substituted-alkanoyl-8-hydroxycarbostyril derivatives and production thereof - Google Patents

5-substituted-alkanoyl-8-hydroxycarbostyril derivatives and production thereof

Info

Publication number
GB1496874A
GB1496874A GB28863/77A GB2886377A GB1496874A GB 1496874 A GB1496874 A GB 1496874A GB 28863/77 A GB28863/77 A GB 28863/77A GB 2886377 A GB2886377 A GB 2886377A GB 1496874 A GB1496874 A GB 1496874A
Authority
GB
United Kingdom
Prior art keywords
substituted
alkyl
alkanoyl
production
hydroxycarbostyril
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28863/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP1295374A external-priority patent/JPS539228B2/ja
Priority claimed from JP1295474A external-priority patent/JPS539229B2/ja
Priority claimed from JP1511574A external-priority patent/JPS539230B2/ja
Priority claimed from JP1511674A external-priority patent/JPS538705B2/ja
Priority claimed from JP1595374A external-priority patent/JPS539231B2/ja
Priority claimed from JP1978774A external-priority patent/JPS5310987B2/ja
Priority claimed from JP2360474A external-priority patent/JPS539232B2/ja
Priority claimed from JP3071774A external-priority patent/JPS5625570B2/ja
Priority claimed from JP3071874A external-priority patent/JPS5146650B2/ja
Priority claimed from JP5831574A external-priority patent/JPS5310990B2/ja
Priority claimed from JP5831774A external-priority patent/JPS5310991B2/ja
Priority claimed from JP6782374A external-priority patent/JPS5310994B2/ja
Priority claimed from JP6782474A external-priority patent/JPS5310995B2/ja
Priority claimed from JP13072174A external-priority patent/JPS5156467A/ja
Priority claimed from JP13072774A external-priority patent/JPS5156473A/ja
Priority claimed from JP13072274A external-priority patent/JPS5156468A/ja
Priority claimed from JP13072474A external-priority patent/JPS5156470A/ja
Priority claimed from JP13071874A external-priority patent/JPS5156464A/ja
Priority claimed from JP49130719A external-priority patent/JPS5156465A/ja
Priority claimed from JP13071774A external-priority patent/JPS5156463A/ja
Priority claimed from JP13072374A external-priority patent/JPS5156469A/ja
Priority claimed from JP13072874A external-priority patent/JPS5156474A/ja
Priority claimed from JP13072574A external-priority patent/JPS5156471A/ja
Priority claimed from JP14034074A external-priority patent/JPS51125290A/ja
Priority claimed from JP14033974A external-priority patent/JPS5165770A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of GB1496874A publication Critical patent/GB1496874A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/32—Esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB28863/77A 1974-01-31 1974-12-27 5-substituted-alkanoyl-8-hydroxycarbostyril derivatives and production thereof Expired GB1496874A (en)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
JP1295374A JPS539228B2 (US06252093-20010626-C00008.png) 1974-01-31 1974-01-31
JP1295474A JPS539229B2 (US06252093-20010626-C00008.png) 1974-01-31 1974-01-31
JP1511574A JPS539230B2 (US06252093-20010626-C00008.png) 1974-02-05 1974-02-05
JP1511674A JPS538705B2 (US06252093-20010626-C00008.png) 1974-02-05 1974-02-05
JP1595374A JPS539231B2 (US06252093-20010626-C00008.png) 1974-02-07 1974-02-07
JP1978774A JPS5310987B2 (US06252093-20010626-C00008.png) 1974-02-18 1974-02-18
JP2360474A JPS539232B2 (US06252093-20010626-C00008.png) 1974-02-27 1974-02-27
JP3071774A JPS5625570B2 (US06252093-20010626-C00008.png) 1974-03-18 1974-03-18
JP3071874A JPS5146650B2 (US06252093-20010626-C00008.png) 1974-03-18 1974-03-18
JP5831574A JPS5310990B2 (US06252093-20010626-C00008.png) 1974-05-22 1974-05-22
JP5831774A JPS5310991B2 (US06252093-20010626-C00008.png) 1974-05-22 1974-05-22
JP6782474A JPS5310995B2 (US06252093-20010626-C00008.png) 1974-06-13 1974-06-13
JP6782374A JPS5310994B2 (US06252093-20010626-C00008.png) 1974-06-13 1974-06-13
JP13072274A JPS5156468A (en) 1974-11-11 1974-11-11 55 * arufua arukiruaminoarukanoiru * 88 arukokishi 3*44 jihidorokarubosuchirirunoseizoho
JP13072474A JPS5156470A (en) 1974-11-11 1974-11-11 55 * 22 arukiruamino 11 hidorokishi * arukiru 88 hidorokishi 3 44 jihidorokarubosuchiriruno seizoho
JP13071874A JPS5156464A (ja) 1974-11-11 1974-11-11 Karubosuchirirujudotaino seizoho
JP49130719A JPS5156465A (en) 1974-11-11 1974-11-11 Karubosuchirirujudotaino seizoho
JP13072874A JPS5156474A (ja) 1974-11-11 1974-11-11 Karubosuchirirujudotaino seizoho
JP13072174A JPS5156467A (en) 1974-11-11 1974-11-11 55 * arufua haroarukanoiru * 88 arukokishi 3 44 jihidorokarubosuchiriruno seizoho
JP13072774A JPS5156473A (ja) 1974-11-11 1974-11-11 Karubosuchirirujudotaino seizoho
JP13072574A JPS5156471A (en) 1974-11-11 1974-11-11 55 * 22 ararukiruamino 11 hidorokishi * arukiru 88 hidorokishi 3 44 jihidorokarubosuchiriruno seizoho
JP13072374A JPS5156469A (en) 1974-11-11 1974-11-11 55 * arufua arukiruaminoarukanoiru * 88 hidorokishi 3 44 jihidorokarubosuchirirunoseizoho
JP13071774A JPS5156463A (ja) 1974-11-11 1974-11-11 Karubosuchirirujudotaino seizoho
JP14034074A JPS51125290A (en) 1974-12-04 1974-12-04 A process for preparing carbostyryl
JP14033974A JPS5165770A (ja) 1974-12-04 1974-12-04 Karubosuchirirujudotaino seizoho

Publications (1)

Publication Number Publication Date
GB1496874A true GB1496874A (en) 1978-01-05

Family

ID=27586766

Family Applications (4)

Application Number Title Priority Date Filing Date
GB28863/77A Expired GB1496874A (en) 1974-01-31 1974-12-27 5-substituted-alkanoyl-8-hydroxycarbostyril derivatives and production thereof
GB55900/74A Expired GB1496769A (en) 1974-01-31 1974-12-27 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof
GB29524/77A Expired GB1496872A (en) 1974-01-31 1974-12-27 Da forfarande for framstellning av karbostyrol- eller 3,4-dihydrokarbosty
GB55897/74A Expired GB1496766A (en) 1974-01-31 1974-12-27 5-substituted-alkyl-8-hydroxycarbostyril derivatives and production thereof

Family Applications After (3)

Application Number Title Priority Date Filing Date
GB55900/74A Expired GB1496769A (en) 1974-01-31 1974-12-27 5-substituted ethyl-8-hydroxycarbostyril derivatives and production thereof
GB29524/77A Expired GB1496872A (en) 1974-01-31 1974-12-27 Da forfarande for framstellning av karbostyrol- eller 3,4-dihydrokarbosty
GB55897/74A Expired GB1496766A (en) 1974-01-31 1974-12-27 5-substituted-alkyl-8-hydroxycarbostyril derivatives and production thereof

Country Status (4)

Country Link
US (2) US4022776A (US06252093-20010626-C00008.png)
DE (2) DE2461596A1 (US06252093-20010626-C00008.png)
FR (3) FR2259610B1 (US06252093-20010626-C00008.png)
GB (4) GB1496874A (US06252093-20010626-C00008.png)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240015A2 (en) 1986-04-02 1987-10-07 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use

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US4313947A (en) * 1974-06-24 1982-02-02 Otsuka Pharmaceutical Co., Ltd. Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use
CH619453A5 (US06252093-20010626-C00008.png) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
JPS609713B2 (ja) * 1976-10-08 1985-03-12 大塚製薬株式会社 カルボスチリル誘導体
JPS5513241A (en) * 1978-07-14 1980-01-30 Otsuka Pharmaceut Co Ltd Remedy for glaucoma
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
US4322425A (en) * 1980-03-14 1982-03-30 Otsuka Pharmaceutical Co., Ltd. Compositions for treating glaucoma
US4348398A (en) * 1980-12-23 1982-09-07 Merck Sharp & Dohme (I.A.) Corp. Quinolinyl ethanolamines
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
IT1121651B (it) * 1981-10-13 1986-04-10 Chiesi Farma Spa Procedimento per la preparazione del 5-(1-idrossi-2-imopropilammino)butil-8-idrossi-carbostirile(procaterolo)
US4578381A (en) * 1982-07-05 1986-03-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
AU565621B2 (en) * 1983-04-26 1987-09-24 Smithkline Beckman Corporation Dopaminergic carbostyrils
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
US4853381A (en) * 1984-04-17 1989-08-01 Glaxo Group Limited Ethanolamine compounds
US4616022A (en) * 1984-08-17 1986-10-07 Warner-Lambert Company Procaterol stabilization
US4845100A (en) * 1985-04-12 1989-07-04 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
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US7829720B2 (en) * 2004-05-04 2010-11-09 Bristol-Myers Squibb Company Process for preparing atazanavir bisulfate and novel forms
US20050256314A1 (en) * 2004-05-04 2005-11-17 Soojin Kim Process employing controlled crystallization in forming crystals of a pharmaceutical
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240015A2 (en) 1986-04-02 1987-10-07 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use

Also Published As

Publication number Publication date
GB1496766A (en) 1978-01-05
US4026897A (en) 1977-05-31
FR2271821B1 (US06252093-20010626-C00008.png) 1978-08-04
FR2259610B1 (US06252093-20010626-C00008.png) 1978-07-21
DE2461861A1 (de) 1975-08-07
GB1496769A (en) 1978-01-05
DE2461596A1 (de) 1975-11-27
FR2271821A1 (US06252093-20010626-C00008.png) 1975-12-19
FR2274303A1 (fr) 1976-01-09
US4022776A (en) 1977-05-10
GB1496872A (en) 1978-01-05
FR2259610A1 (US06252093-20010626-C00008.png) 1975-08-29
FR2274303B1 (US06252093-20010626-C00008.png) 1980-02-22

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PS Patent sealed [section 19, patents act 1949]
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Effective date: 19941226