GB1491390A - Production of an n-(substituted)piperazine compound - Google Patents

Production of an n-(substituted)piperazine compound

Info

Publication number
GB1491390A
GB1491390A GB19962/76A GB1996276A GB1491390A GB 1491390 A GB1491390 A GB 1491390A GB 19962/76 A GB19962/76 A GB 19962/76A GB 1996276 A GB1996276 A GB 1996276A GB 1491390 A GB1491390 A GB 1491390A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
dialkanolamine
cycloalkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB19962/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texaco Development Corp
Original Assignee
Texaco Development Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texaco Development Corp filed Critical Texaco Development Corp
Publication of GB1491390A publication Critical patent/GB1491390A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/023—Preparation; Separation; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Abstract

1491390 Piperazine derivatives TEXACO DEVELOPMENT CORP 14 May 1976 [2 June 1975 (2)] 19962/76 Heading C2C A process for preparing piperazine derivatives of the formula wherein R<SP>1</SP>, R<SP>2</SP> and R<SP>3</SP> are hydrogen or-alkyl; R<SP>4</SP> is an optionally substituted alkyl, cycloalkyl, saturated heterocyclic or aryl radical and R<SP>5</SP> is hydrogen or an optionally substituted alkyl, cycloalkyl, saturated heterocyclic or aryl radical, are prepared by contacting a dialkanolamine of the formula with a compound of the formula R<SP>5</SP>.NH 2 in the presence of a phosphorous compound at a temperature of from 200‹ to 350‹ C. under a pressure sufficient to maintain the reactants in the liquid phase. The phosphorous compound is suitably a phosphoric or phosphorous acid derivative and is preferably present in an amount of from 0À1 to 10À0 mole per cent, based upon the dialkanolamine.
GB19962/76A 1975-06-02 1976-05-14 Production of an n-(substituted)piperazine compound Expired GB1491390A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58300575A 1975-06-02 1975-06-02
US58300675A 1975-06-02 1975-06-02

Publications (1)

Publication Number Publication Date
GB1491390A true GB1491390A (en) 1977-11-09

Family

ID=27078704

Family Applications (1)

Application Number Title Priority Date Filing Date
GB19962/76A Expired GB1491390A (en) 1975-06-02 1976-05-14 Production of an n-(substituted)piperazine compound

Country Status (8)

Country Link
JP (1) JPS51149290A (en)
DE (1) DE2624042A1 (en)
FR (1) FR2313369A1 (en)
GB (1) GB1491390A (en)
IT (1) IT1063087B (en)
NL (1) NL7605640A (en)
NO (1) NO761856L (en)
SE (1) SE7606174L (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845218A (en) * 1986-02-18 1989-07-04 Basf Aktiengesellschaft Preparation of n-methylpiperazine
US5110928A (en) * 1990-03-15 1992-05-05 Basf Aktiengesellschaft Preparation of n-aryl-substituted 2-aminoalkyl-2-hydroxyalkylamines and n-aryl-substituted piperazines

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5742679A (en) * 1980-08-29 1982-03-10 Otsuka Pharmaceut Co Ltd Preparation of phenylpiperazine derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2636033A (en) 1950-06-01 1953-04-21 Colgate Palmolive Peet Co Process for preparing n-n' dialkanol piperazine
DE1002359B (en) 1954-01-30 1957-02-14 Hoechst Ag Process for the preparation of N, N'-Dioxyaethylpiperazine
US2910477A (en) 1956-10-18 1959-10-27 Dow Chemical Co Preparation of piperazine
US3869527A (en) 1971-08-17 1975-03-04 Leo Ab Secondary phosphate esters
GB1424513A (en) 1972-06-13 1976-02-11 Ciba Geigy Ag Organic phosphates

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4845218A (en) * 1986-02-18 1989-07-04 Basf Aktiengesellschaft Preparation of n-methylpiperazine
US5110928A (en) * 1990-03-15 1992-05-05 Basf Aktiengesellschaft Preparation of n-aryl-substituted 2-aminoalkyl-2-hydroxyalkylamines and n-aryl-substituted piperazines

Also Published As

Publication number Publication date
NO761856L (en) 1976-12-03
NL7605640A (en) 1976-12-06
FR2313369B3 (en) 1979-02-16
DE2624042A1 (en) 1976-12-23
SE7606174L (en) 1976-12-03
FR2313369A1 (en) 1976-12-31
JPS51149290A (en) 1976-12-22
IT1063087B (en) 1985-02-11

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee