GB1479189A - Benzodiazepine derivatives - Google Patents
Benzodiazepine derivativesInfo
- Publication number
- GB1479189A GB1479189A GB3761674A GB3761674A GB1479189A GB 1479189 A GB1479189 A GB 1479189A GB 3761674 A GB3761674 A GB 3761674A GB 3761674 A GB3761674 A GB 3761674A GB 1479189 A GB1479189 A GB 1479189A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkoxy
- compounds
- phch
- alkylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fodder In General (AREA)
Abstract
1479189 Triazinobenzodiazepines E R SQUIBB & SONS Inc 28 Aug 1974 [5 Oct 1973] 37616/74 Heading C2C Compounds of the general formula (R 1 =H, alkyl, Ph, PhCH 2 ; R 2 =H, alkyl; R 3 =H, R 4 (CH 2 ) 2-4; R 4 =NH 2 , alkylamino, dialkylamino or A=CHQ, O, NQ; Q=H, alkyl; m=0, 1; R 5 =H, halogen, NO 2 , CN, CF 2 alkyl, alkoxy, alkylthio) and their acid addition salts are prepared by reacting a compound of the formula (R 6 = halogen, SH, alkoxy, alkylthio, phenalkylthio; R 7 =alkyl, Ph, PhCH 2 ) with morpholinoglyoxylhydrazide, or with tert.-butyl or benzyl (optionally alkoxy or nitro substituted) carbazate followed by reaction with an oxalic acid ester, an alkanol and an anhydrous acid, optionally followed by introduction of the 2-substituent (e.g. via the Tl derivative), removal of the benzyl group and/or salt formation. The 2-unsubstituted compounds are central nervous system depressants, and the 2-substituted compounds are anti-inflammatory agents. They may be administered in the form of pharmaceutical or veterinary preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40407273A | 1973-10-05 | 1973-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1479189A true GB1479189A (en) | 1977-07-06 |
Family
ID=23598031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3761674A Expired GB1479189A (en) | 1973-10-05 | 1974-08-28 | Benzodiazepine derivatives |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS5062997A (en) |
| CA (1) | CA1027943A (en) |
| DE (1) | DE2447467A1 (en) |
| FR (1) | FR2246274B1 (en) |
| GB (1) | GB1479189A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3898212A (en) * | 1974-08-09 | 1975-08-05 | Squibb & Sons Inc | Triazino(4,3-D) (1,4) benzodiazepine-3,4,7-triones |
-
1974
- 1974-08-20 CA CA207,436A patent/CA1027943A/en not_active Expired
- 1974-08-28 GB GB3761674A patent/GB1479189A/en not_active Expired
- 1974-09-13 FR FR7431090A patent/FR2246274B1/fr not_active Expired
- 1974-10-04 DE DE19742447467 patent/DE2447467A1/en not_active Withdrawn
- 1974-10-05 JP JP49115102A patent/JPS5062997A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1027943A (en) | 1978-03-14 |
| JPS5062997A (en) | 1975-05-29 |
| FR2246274A1 (en) | 1975-05-02 |
| DE2447467A1 (en) | 1975-04-17 |
| FR2246274B1 (en) | 1978-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |