GB1458049A - Process for preparing aryl-substituted pyridones - Google Patents

Process for preparing aryl-substituted pyridones

Info

Publication number
GB1458049A
GB1458049A GB4107475A GB4107475A GB1458049A GB 1458049 A GB1458049 A GB 1458049A GB 4107475 A GB4107475 A GB 4107475A GB 4107475 A GB4107475 A GB 4107475A GB 1458049 A GB1458049 A GB 1458049A
Authority
GB
United Kingdom
Prior art keywords
aryl
dec
optionally substituted
substituted pyridones
preparing aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4107475A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AFFILIATED MED RES
Original Assignee
AFFILIATED MED RES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US00315836A external-priority patent/US3839346A/en
Application filed by AFFILIATED MED RES filed Critical AFFILIATED MED RES
Publication of GB1458049A publication Critical patent/GB1458049A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB4107475A 1972-12-18 1973-12-18 Process for preparing aryl-substituted pyridones Expired GB1458049A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US00315836A US3839346A (en) 1972-12-18 1972-12-18 N-substituted pyridone and general method for preparing pyridones
US38065573A 1973-07-19 1973-07-19

Publications (1)

Publication Number Publication Date
GB1458049A true GB1458049A (en) 1976-12-08

Family

ID=26980095

Family Applications (2)

Application Number Title Priority Date Filing Date
GB4107475A Expired GB1458049A (en) 1972-12-18 1973-12-18 Process for preparing aryl-substituted pyridones
GB5864273A Expired GB1458048A (en) 1972-12-18 1973-12-18 Pharmaceutical composition

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB5864273A Expired GB1458048A (en) 1972-12-18 1973-12-18 Pharmaceutical composition

Country Status (6)

Country Link
JP (1) JPS4987677A (zh)
DE (2) DE2366349C2 (zh)
ES (1) ES421598A1 (zh)
FR (1) FR2232316B1 (zh)
GB (2) GB1458049A (zh)
NL (1) NL7317316A (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006122154A3 (en) * 2005-05-10 2007-07-26 Intermune Inc Pyridone derivatives for modulating stress-activated protein kinase system
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9359379B2 (en) 2012-10-02 2016-06-07 Intermune, Inc. Anti-fibrotic pyridinones
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1049411A (en) * 1972-12-18 1979-02-27 Affiliated Medical Research N-substituted pyridone and general method for preparing pyridones
JPS5350179A (en) * 1976-10-15 1978-05-08 Rikagaku Kenkyusho Novel 2-pyridone compounds and their preparation
JP4542743B2 (ja) * 2002-12-26 2010-09-15 Ｋｄｌ株式会社 ピリドン誘導体の溶液状医薬組成物
MX2007009796A (es) 2007-08-14 2009-02-25 Cell Therapy And Technology S Gel conteniendo pirfenidona.
ES2913095T3 (es) * 2011-01-31 2022-05-31 Avalyn Pharma Inc Compuestos de pirfenidona y análogos de piridona en aerosol y usos de los mismos
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
MX346763B (es) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné.
ITUB20154832A1 (it) * 2015-10-29 2017-04-29 Procos Spa Processo per la sintesi di pirfenidone
EP3661506A4 (en) * 2017-07-31 2021-04-21 Washington University PIRFENIDONE DERIVATIVES FOR MODULATION OF B LYMPHOCYTE ACTIVITY AND ORGAN PROTECTION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2947755A (en) * 1959-02-05 1960-08-02 Wallace & Tiernan Inc Substituted 1-m-aminophenyl-2-pyridones
US3655897A (en) * 1971-01-25 1972-04-11 Merck & Co Inc Anti-inflammatory agents

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9527816B2 (en) 2005-05-10 2016-12-27 Intermune, Inc. Method of modulating stress-activated protein kinase system
US10010536B2 (en) 2005-05-10 2018-07-03 Intermune, Inc. Method of modulating stress-activated protein kinase system
EA015252B1 (ru) * 2005-05-10 2011-06-30 Интермьюн, Инк. Способ модуляции стресс-активированной протеинкиназной системы
US8741936B2 (en) 2005-05-10 2014-06-03 Intermune, Inc. Method of modulating stress-activated protein kinase system
WO2006122154A3 (en) * 2005-05-10 2007-07-26 Intermune Inc Pyridone derivatives for modulating stress-activated protein kinase system
US7728013B2 (en) 2005-05-10 2010-06-01 Intermune, Inc. Method of modulating stress-activated protein kinase system
US8969347B2 (en) 2008-06-03 2015-03-03 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9290450B2 (en) 2008-06-03 2016-03-22 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
USRE47142E1 (en) 2008-06-03 2018-11-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
US9675593B2 (en) 2012-10-02 2017-06-13 Intermune, Inc. Anti-fibrotic pyridinones
US9359379B2 (en) 2012-10-02 2016-06-07 Intermune, Inc. Anti-fibrotic pyridinones
US10376497B2 (en) 2012-10-02 2019-08-13 Intermune, Inc. Anti-fibrotic pyridinones
US10898474B2 (en) 2012-10-02 2021-01-26 Intermune, Inc. Anti-fibrotic pyridinones
US10233195B2 (en) 2014-04-02 2019-03-19 Intermune, Inc. Anti-fibrotic pyridinones
US10544161B2 (en) 2014-04-02 2020-01-28 Intermune, Inc. Anti-fibrotic pyridinones

Also Published As

Publication number Publication date
GB1458048A (en) 1976-12-08
FR2232316B1 (zh) 1978-03-24
DE2362958A1 (de) 1974-06-27
DE2366349C2 (de) 1986-03-27
NL7317316A (zh) 1974-06-20
JPS4987677A (zh) 1974-08-22
DE2362958C2 (de) 1984-06-14
ES421598A1 (es) 1977-01-01
FR2232316A1 (zh) 1975-01-03
AU6374673A (en) 1975-06-19

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee