JPS4987677A - - Google Patents
Info
- Publication number
- JPS4987677A JPS4987677A JP14179773A JP14179773A JPS4987677A JP S4987677 A JPS4987677 A JP S4987677A JP 14179773 A JP14179773 A JP 14179773A JP 14179773 A JP14179773 A JP 14179773A JP S4987677 A JPS4987677 A JP S4987677A
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00315836A US3839346A (en) | 1972-12-18 | 1972-12-18 | N-substituted pyridone and general method for preparing pyridones |
| US38065573A | 1973-07-19 | 1973-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS4987677A true JPS4987677A (zh) | 1974-08-22 |
Family
ID=26980095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14179773A Pending JPS4987677A (zh) | 1972-12-18 | 1973-12-18 |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4987677A (zh) |
| DE (2) | DE2366349C2 (zh) |
| ES (1) | ES421598A1 (zh) |
| FR (1) | FR2232316B1 (zh) |
| GB (2) | GB1458049A (zh) |
| NL (1) | NL7317316A (zh) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5350179A (en) * | 1976-10-15 | 1978-05-08 | Rikagaku Kenkyusho | Novel 2-pyridone compounds and their preparation |
| JP2004203795A (ja) * | 2002-12-26 | 2004-07-22 | Kdl Inc | ピリドン誘導体の溶液状医薬組成物 |
| WO2009022899A1 (es) | 2007-08-14 | 2009-02-19 | Cell Therapy Technology, S.A. De C.V. | Gel conteniendo pirfenidona |
| JP2012121931A (ja) * | 2005-05-10 | 2012-06-28 | Intermune Inc | ストレス活性化蛋白質キナーゼ系をモジュレートするためのピリドン誘導体 |
| WO2013012307A1 (es) | 2011-07-19 | 2013-01-24 | Cell Therapy And Techonology S.A. De C.V. | Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresión de la insuficiencia renal crónica, contractura capsular mamaria y fibrosis hepatica humanas |
| WO2013147577A1 (es) | 2012-03-28 | 2013-10-03 | Cell Therapy and Technology S.A. DE C.V. | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné |
| JP2017031192A (ja) * | 2011-01-31 | 2017-02-09 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| JP2020530005A (ja) * | 2017-07-31 | 2020-10-15 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | Ｂリンパ球活性の調節及び臓器保護のためのピルフェニドン誘導体 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1049411A (en) * | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| MX2010012848A (es) | 2008-06-03 | 2011-03-01 | Intermune Inc | Compuestos y metodos para tratar trastornos inflamatorios y fibroticos. |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| CN106459042B (zh) | 2014-04-02 | 2019-06-28 | 英特穆恩公司 | 抗纤维化吡啶酮类 |
| ITUB20154832A1 (it) * | 2015-10-29 | 2017-04-29 | Procos Spa | Processo per la sintesi di pirfenidone |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2947755A (en) * | 1959-02-05 | 1960-08-02 | Wallace & Tiernan Inc | Substituted 1-m-aminophenyl-2-pyridones |
| US3655897A (en) * | 1971-01-25 | 1972-04-11 | Merck & Co Inc | Anti-inflammatory agents |
-
1973
- 1973-12-18 FR FR7345342A patent/FR2232316B1/fr not_active Expired
- 1973-12-18 ES ES421598A patent/ES421598A1/es not_active Expired
- 1973-12-18 JP JP14179773A patent/JPS4987677A/ja active Pending
- 1973-12-18 NL NL7317316A patent/NL7317316A/xx not_active Application Discontinuation
- 1973-12-18 DE DE19732366349 patent/DE2366349C2/de not_active Expired
- 1973-12-18 GB GB4107475A patent/GB1458049A/en not_active Expired
- 1973-12-18 DE DE19732362958 patent/DE2362958C2/de not_active Expired
- 1973-12-18 GB GB5864273A patent/GB1458048A/en not_active Expired
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5350179A (en) * | 1976-10-15 | 1978-05-08 | Rikagaku Kenkyusho | Novel 2-pyridone compounds and their preparation |
| JPS5526138B2 (zh) * | 1976-10-15 | 1980-07-11 | ||
| JP2004203795A (ja) * | 2002-12-26 | 2004-07-22 | Kdl Inc | ピリドン誘導体の溶液状医薬組成物 |
| JP4542743B2 (ja) * | 2002-12-26 | 2010-09-15 | Ｋｄｌ株式会社 | ピリドン誘導体の溶液状医薬組成物 |
| JP2012121931A (ja) * | 2005-05-10 | 2012-06-28 | Intermune Inc | ストレス活性化蛋白質キナーゼ系をモジュレートするためのピリドン誘導体 |
| EP2591784A1 (en) | 2005-05-10 | 2013-05-15 | Intermune, Inc. | Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system |
| WO2009022899A1 (es) | 2007-08-14 | 2009-02-19 | Cell Therapy Technology, S.A. De C.V. | Gel conteniendo pirfenidona |
| JP2017031192A (ja) * | 2011-01-31 | 2017-02-09 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| WO2013012307A1 (es) | 2011-07-19 | 2013-01-24 | Cell Therapy And Techonology S.A. De C.V. | Procedimiento para la fabricación de una composición farmacéutica en forma de tabletas de liberación prolongada conteniendo pirfenidona y su aplicación en la regresión de la insuficiencia renal crónica, contractura capsular mamaria y fibrosis hepatica humanas |
| EP2907506A1 (en) | 2011-07-19 | 2015-08-19 | Cell Therapy And Technology, S.A. De C.V. | Method for manufacturing a pharmaceutical composition in the form of extended-release tablets containing pirfenidone and use thereof in the regression of chronic renal insufficiency, breast capsular contracture and hepatic fibrosis in humans |
| WO2013147577A1 (es) | 2012-03-28 | 2013-10-03 | Cell Therapy and Technology S.A. DE C.V. | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné |
| JP2020530005A (ja) * | 2017-07-31 | 2020-10-15 | ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | Ｂリンパ球活性の調節及び臓器保護のためのピルフェニドン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6374673A (en) | 1975-06-19 |
| GB1458049A (en) | 1976-12-08 |
| FR2232316A1 (zh) | 1975-01-03 |
| DE2366349C2 (de) | 1986-03-27 |
| FR2232316B1 (zh) | 1978-03-24 |
| NL7317316A (zh) | 1974-06-20 |
| ES421598A1 (es) | 1977-01-01 |
| DE2362958A1 (de) | 1974-06-27 |
| GB1458048A (en) | 1976-12-08 |
| DE2362958C2 (de) | 1984-06-14 |