GB1440722A - 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity - Google Patents
2-1-piperazinyl-quinoxaline compounds having pharmaceutical activityInfo
- Publication number
- GB1440722A GB1440722A GB3017674A GB3017674A GB1440722A GB 1440722 A GB1440722 A GB 1440722A GB 3017674 A GB3017674 A GB 3017674A GB 3017674 A GB3017674 A GB 3017674A GB 1440722 A GB1440722 A GB 1440722A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- hydrogen
- alkanoyl
- carbamoyl
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37902273A | 1973-07-13 | 1973-07-13 | |
US46538174A | 1974-04-29 | 1974-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1440722A true GB1440722A (en) | 1976-06-23 |
Family
ID=27008442
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3017674A Expired GB1440722A (en) | 1973-07-13 | 1974-07-08 | 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5037791A (xx) |
AU (1) | AU7073174A (xx) |
BG (1) | BG21606A3 (xx) |
CH (1) | CH605919A5 (xx) |
DD (1) | DD112127A5 (xx) |
DE (1) | DE2433397A1 (xx) |
DK (1) | DK342674A (xx) |
ES (1) | ES428107A1 (xx) |
FI (1) | FI193974A (xx) |
FR (1) | FR2236499B1 (xx) |
GB (1) | GB1440722A (xx) |
IE (1) | IE39869B1 (xx) |
IL (1) | IL45158A0 (xx) |
LU (1) | LU70510A1 (xx) |
NL (1) | NL7408705A (xx) |
NO (1) | NO742351L (xx) |
RO (1) | RO63539A (xx) |
SE (1) | SE417316B (xx) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082845A (en) | 1977-04-25 | 1978-04-04 | Merck & Co., Inc. | 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines |
US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
US4091101A (en) * | 1977-06-15 | 1978-05-23 | Merck & Co., Inc. | 6-(1-Piperazinyl)quinoxaline |
US4107309A (en) * | 1977-05-23 | 1978-08-15 | American Cyanamid Company | Substituted imidazo[1,2-d]-as-triazines |
WO2000076984A2 (en) * | 1999-05-21 | 2000-12-21 | Biovitrum Ab | Novel compounds, their use and preparation |
US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
JP2003502317A (ja) * | 1999-05-21 | 2003-01-21 | ビオヴィトルム・アクチボラゲット | 新規化合物、その使用および製造 |
WO2004000830A1 (en) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Novel compounds, their use and preparation |
WO2004009586A1 (en) * | 2002-07-19 | 2004-01-29 | Biovitrum Ab | Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders |
WO2005033088A1 (en) * | 2003-09-30 | 2005-04-14 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
EA007539B1 (ru) * | 2002-07-19 | 2006-10-27 | Биовитрум Аб | Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором |
US8013156B2 (en) | 2003-03-19 | 2011-09-06 | Exelixis, Inc. | Tie-2 modulators and methods of use |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0094498A3 (en) * | 1982-05-06 | 1985-04-03 | American Cyanamid Company | Antiatherosclerotic 1-piperazine derivatives |
ES2042395B1 (es) * | 1992-02-27 | 1994-06-16 | Promotora Catalana De Inversio | Procedimiento para la obtencion de derivados de 2-ciano-3-piperacinilquinoxalinas. |
FR2731221B1 (fr) * | 1995-03-01 | 1997-05-30 | Pf Medicament | Nouveaux derives de l'ethyl-1 dihydro-1, 2 oxo-2 methylamino-3 quinoxaline, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
CA2308057A1 (en) * | 1997-10-24 | 1999-05-06 | Neurogen Corporation | 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl)piperazines being dopamine d4 receptor subtype ligands |
US6040448A (en) | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
AU6242999A (en) * | 1998-09-02 | 2000-03-21 | Neurogen Corporation | 2-aryl-4-(1-(4-heteroaryl)piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands |
JP4707261B2 (ja) * | 2001-05-15 | 2011-06-22 | 日本エンバイロケミカルズ株式会社 | キノキサリン系化合物および工業用殺菌組成物 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL260335A (xx) * | 1960-01-22 | |||
CH450434A (de) * | 1961-12-14 | 1968-01-31 | Ciba Geigy | Verfahren zur Herstellung von Diazinen |
BE788451A (fr) * | 1971-09-08 | 1973-03-06 | Bayer Ag | Nouvelles 2-amino-quinoxalines, leur procede de preparation et leur application comme insecticides, acaricides et fongicides |
GB1457005A (en) * | 1972-11-20 | 1976-12-01 | Pfizer | 2-substituted-3-aminoquinoxalines |
-
1974
- 1974-06-25 FI FI1939/74A patent/FI193974A/fi unknown
- 1974-06-26 DK DK342674A patent/DK342674A/da unknown
- 1974-06-27 NL NL7408705A patent/NL7408705A/xx not_active Application Discontinuation
- 1974-06-27 NO NO742351A patent/NO742351L/no unknown
- 1974-06-27 SE SE7408486A patent/SE417316B/xx unknown
- 1974-07-01 IL IL45158A patent/IL45158A0/xx unknown
- 1974-07-02 AU AU70731/74A patent/AU7073174A/en not_active Expired
- 1974-07-02 IE IE1397/74A patent/IE39869B1/xx unknown
- 1974-07-08 GB GB3017674A patent/GB1440722A/en not_active Expired
- 1974-07-09 ES ES428107A patent/ES428107A1/es not_active Expired
- 1974-07-11 LU LU70510A patent/LU70510A1/xx unknown
- 1974-07-11 FR FR7424114A patent/FR2236499B1/fr not_active Expired
- 1974-07-11 DE DE2433397A patent/DE2433397A1/de active Pending
- 1974-07-11 DD DD179871A patent/DD112127A5/xx unknown
- 1974-07-12 CH CH964874A patent/CH605919A5/xx not_active IP Right Cessation
- 1974-07-13 BG BG027222A patent/BG21606A3/xx unknown
- 1974-07-13 RO RO7400079481A patent/RO63539A/ro unknown
- 1974-07-13 JP JP49079774A patent/JPS5037791A/ja active Pending
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082845A (en) | 1977-04-25 | 1978-04-04 | Merck & Co., Inc. | 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines |
US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
FR2388811A1 (fr) * | 1977-04-25 | 1978-11-24 | Merck & Co Inc | 3-(1-piperazinyl)-pyrido(2,3-b)pyrazines utiles comme medicaments |
US4107309A (en) * | 1977-05-23 | 1978-08-15 | American Cyanamid Company | Substituted imidazo[1,2-d]-as-triazines |
US4091101A (en) * | 1977-06-15 | 1978-05-23 | Merck & Co., Inc. | 6-(1-Piperazinyl)quinoxaline |
JP2003502317A (ja) * | 1999-05-21 | 2003-01-21 | ビオヴィトルム・アクチボラゲット | 新規化合物、その使用および製造 |
US7534794B2 (en) | 1999-05-21 | 2009-05-19 | Biovitrum Ab | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
WO2000076984A2 (en) * | 1999-05-21 | 2000-12-21 | Biovitrum Ab | Novel compounds, their use and preparation |
WO2000076984A3 (en) * | 1999-05-21 | 2001-02-08 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
US7071180B2 (en) | 1999-05-21 | 2006-07-04 | Biovitrum Ab | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
WO2004000830A1 (en) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Novel compounds, their use and preparation |
WO2004009586A1 (en) * | 2002-07-19 | 2004-01-29 | Biovitrum Ab | Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders |
EA007539B1 (ru) * | 2002-07-19 | 2006-10-27 | Биовитрум Аб | Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором |
US7244722B2 (en) | 2002-07-19 | 2007-07-17 | Biovitrum Ab | Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones |
US8013156B2 (en) | 2003-03-19 | 2011-09-06 | Exelixis, Inc. | Tie-2 modulators and methods of use |
WO2005033088A1 (en) * | 2003-09-30 | 2005-04-14 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
AU2004278372B2 (en) * | 2003-09-30 | 2010-02-18 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
CN1886389B (zh) * | 2003-09-30 | 2010-07-21 | 詹森药业有限公司 | 喹喔啉化合物 |
Also Published As
Publication number | Publication date |
---|---|
FI193974A (xx) | 1975-01-14 |
ES428107A1 (es) | 1976-11-16 |
LU70510A1 (xx) | 1975-03-27 |
DK342674A (xx) | 1975-03-03 |
DD112127A5 (xx) | 1975-03-20 |
BG21606A3 (bg) | 1976-07-20 |
DE2433397A1 (de) | 1975-02-06 |
SE7408486L (sv) | 1975-01-14 |
NL7408705A (nl) | 1975-01-15 |
IE39869L (en) | 1975-01-13 |
RO63539A (fr) | 1978-07-15 |
IL45158A0 (en) | 1974-11-29 |
CH605919A5 (xx) | 1978-10-13 |
NO742351L (xx) | 1975-02-10 |
FR2236499A1 (xx) | 1975-02-07 |
FR2236499B1 (xx) | 1977-04-15 |
SE417316B (sv) | 1981-03-09 |
IE39869B1 (en) | 1979-01-17 |
AU7073174A (en) | 1976-01-08 |
JPS5037791A (xx) | 1975-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |