GB1440722A - 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity - Google Patents
2-1-piperazinyl-quinoxaline compounds having pharmaceutical activityInfo
- Publication number
- GB1440722A GB1440722A GB3017674A GB3017674A GB1440722A GB 1440722 A GB1440722 A GB 1440722A GB 3017674 A GB3017674 A GB 3017674A GB 3017674 A GB3017674 A GB 3017674A GB 1440722 A GB1440722 A GB 1440722A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- hydrogen
- alkanoyl
- carbamoyl
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RELPOLSGTUYMFR-UHFFFAOYSA-N 2-piperazin-1-ylquinoxaline Chemical class C1CNCCN1C1=CN=C(C=CC=C2)C2=N1 RELPOLSGTUYMFR-UHFFFAOYSA-N 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000001589 carboacyl group Chemical group 0.000 abstract 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 3
- 125000005118 N-alkylcarbamoyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- 229930194542 Keto Natural products 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000003435 aroyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000005110 aryl thio group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 abstract 2
- 125000005277 alkyl imino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 230000036528 appetite Effects 0.000 abstract 1
- 235000019789 appetite Nutrition 0.000 abstract 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- -1 carboxy, carbamoyl Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 abstract 1
- 125000004995 haloalkylthio group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 150000003252 quinoxalines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37902273A | 1973-07-13 | 1973-07-13 | |
| US46538174A | 1974-04-29 | 1974-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1440722A true GB1440722A (en) | 1976-06-23 |
Family
ID=27008442
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3017674A Expired GB1440722A (en) | 1973-07-13 | 1974-07-08 | 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity |
Country Status (18)
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082845A (en) | 1977-04-25 | 1978-04-04 | Merck & Co., Inc. | 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines |
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| US4091101A (en) * | 1977-06-15 | 1978-05-23 | Merck & Co., Inc. | 6-(1-Piperazinyl)quinoxaline |
| US4107309A (en) * | 1977-05-23 | 1978-08-15 | American Cyanamid Company | Substituted imidazo[1,2-d]-as-triazines |
| WO2000076984A3 (en) * | 1999-05-21 | 2001-02-08 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
| US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| JP2003502317A (ja) * | 1999-05-21 | 2003-01-21 | ビオヴィトルム・アクチボラゲット | 新規化合物、その使用および製造 |
| WO2004000830A1 (en) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Novel compounds, their use and preparation |
| WO2004009586A1 (en) * | 2002-07-19 | 2004-01-29 | Biovitrum Ab | Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders |
| WO2005033088A1 (en) * | 2003-09-30 | 2005-04-14 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
| EA007539B1 (ru) * | 2002-07-19 | 2006-10-27 | Биовитрум Аб | Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором |
| US8013156B2 (en) | 2003-03-19 | 2011-09-06 | Exelixis, Inc. | Tie-2 modulators and methods of use |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0094498A3 (en) * | 1982-05-06 | 1985-04-03 | American Cyanamid Company | Antiatherosclerotic 1-piperazine derivatives |
| ES2042395B1 (es) * | 1992-02-27 | 1994-06-16 | Promotora Catalana De Inversio | Procedimiento para la obtencion de derivados de 2-ciano-3-piperacinilquinoxalinas. |
| FR2731221B1 (fr) * | 1995-03-01 | 1997-05-30 | Pf Medicament | Nouveaux derives de l'ethyl-1 dihydro-1, 2 oxo-2 methylamino-3 quinoxaline, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
| AU9810498A (en) * | 1997-10-24 | 1999-05-17 | Neurogen Corporation | 1-(2-naphthyl) and 1-(2-azanaphthyl)-4 -(1-phenylmethyl)piperazines being dopamine d4 receptor subtyp e ligands |
| US6040448A (en) | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
| WO2000012500A2 (en) * | 1998-09-02 | 2000-03-09 | Neurogen Corporation | 2-aryl-4-(1-[4-heteroaryl]piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands |
| JP4707261B2 (ja) * | 2001-05-15 | 2011-06-22 | 日本エンバイロケミカルズ株式会社 | キノキサリン系化合物および工業用殺菌組成物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL260335A (enrdf_load_stackoverflow) * | 1960-01-22 | |||
| CH450434A (de) * | 1961-12-14 | 1968-01-31 | Ciba Geigy | Verfahren zur Herstellung von Diazinen |
| BE788451A (fr) * | 1971-09-08 | 1973-03-06 | Bayer Ag | Nouvelles 2-amino-quinoxalines, leur procede de preparation et leur application comme insecticides, acaricides et fongicides |
| GB1457400A (en) * | 1972-11-20 | 1976-12-01 | Pfizer | Pharmaceutical compositions containing 2-substituted quinoxa lines |
-
1974
- 1974-06-25 FI FI1939/74A patent/FI193974A7/fi unknown
- 1974-06-26 DK DK342674A patent/DK342674A/da unknown
- 1974-06-27 SE SE7408486A patent/SE417316B/xx unknown
- 1974-06-27 NL NL7408705A patent/NL7408705A/xx not_active Application Discontinuation
- 1974-06-27 NO NO742351A patent/NO742351L/no unknown
- 1974-07-01 IL IL45158A patent/IL45158A0/xx unknown
- 1974-07-02 IE IE1397/74A patent/IE39869B1/xx unknown
- 1974-07-02 AU AU70731/74A patent/AU7073174A/en not_active Expired
- 1974-07-08 GB GB3017674A patent/GB1440722A/en not_active Expired
- 1974-07-09 ES ES428107A patent/ES428107A1/es not_active Expired
- 1974-07-11 LU LU70510A patent/LU70510A1/xx unknown
- 1974-07-11 DE DE2433397A patent/DE2433397A1/de active Pending
- 1974-07-11 DD DD179871A patent/DD112127A5/xx unknown
- 1974-07-11 FR FR7424114A patent/FR2236499B1/fr not_active Expired
- 1974-07-12 CH CH964874A patent/CH605919A5/xx not_active IP Right Cessation
- 1974-07-13 RO RO7400079481A patent/RO63539A/ro unknown
- 1974-07-13 JP JP49079774A patent/JPS5037791A/ja active Pending
- 1974-07-13 BG BG027222A patent/BG21606A3/xx unknown
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| FR2388811A1 (fr) * | 1977-04-25 | 1978-11-24 | Merck & Co Inc | 3-(1-piperazinyl)-pyrido(2,3-b)pyrazines utiles comme medicaments |
| US4082845A (en) | 1977-04-25 | 1978-04-04 | Merck & Co., Inc. | 3-(1-Piperazinyl)-pyrido[2,3-b]pyrazines |
| US4107309A (en) * | 1977-05-23 | 1978-08-15 | American Cyanamid Company | Substituted imidazo[1,2-d]-as-triazines |
| US4091101A (en) * | 1977-06-15 | 1978-05-23 | Merck & Co., Inc. | 6-(1-Piperazinyl)quinoxaline |
| US7071180B2 (en) | 1999-05-21 | 2006-07-04 | Biovitrum Ab | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| WO2000076984A3 (en) * | 1999-05-21 | 2001-02-08 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
| US6465467B1 (en) | 1999-05-21 | 2002-10-15 | Biovitrum Ab | Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| JP2003502317A (ja) * | 1999-05-21 | 2003-01-21 | ビオヴィトルム・アクチボラゲット | 新規化合物、その使用および製造 |
| US7534794B2 (en) | 1999-05-21 | 2009-05-19 | Biovitrum Ab | Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases |
| WO2004000830A1 (en) | 2002-06-19 | 2003-12-31 | Biovitrum Ab | Novel compounds, their use and preparation |
| EA007539B1 (ru) * | 2002-07-19 | 2006-10-27 | Биовитрум Аб | Новые производные пиперазинона для лечения нарушений, связанных с 5-нт2а-рецептором |
| US7244722B2 (en) | 2002-07-19 | 2007-07-17 | Biovitrum Ab | Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones |
| WO2004009586A1 (en) * | 2002-07-19 | 2004-01-29 | Biovitrum Ab | Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders |
| US8013156B2 (en) | 2003-03-19 | 2011-09-06 | Exelixis, Inc. | Tie-2 modulators and methods of use |
| WO2005033088A1 (en) * | 2003-09-30 | 2005-04-14 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
| AU2004278372B2 (en) * | 2003-09-30 | 2010-02-18 | Janssen Pharmaceutica N.V. | Quinoxaline compounds |
| CN1886389B (zh) * | 2003-09-30 | 2010-07-21 | 詹森药业有限公司 | 喹喔啉化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| LU70510A1 (enrdf_load_stackoverflow) | 1975-03-27 |
| IE39869B1 (en) | 1979-01-17 |
| JPS5037791A (enrdf_load_stackoverflow) | 1975-04-08 |
| FI193974A7 (enrdf_load_stackoverflow) | 1975-01-14 |
| DK342674A (enrdf_load_stackoverflow) | 1975-03-03 |
| DE2433397A1 (de) | 1975-02-06 |
| IE39869L (en) | 1975-01-13 |
| IL45158A0 (en) | 1974-11-29 |
| DD112127A5 (enrdf_load_stackoverflow) | 1975-03-20 |
| NL7408705A (nl) | 1975-01-15 |
| BG21606A3 (bg) | 1976-07-20 |
| RO63539A (fr) | 1978-07-15 |
| SE7408486L (sv) | 1975-01-14 |
| NO742351L (enrdf_load_stackoverflow) | 1975-02-10 |
| FR2236499A1 (enrdf_load_stackoverflow) | 1975-02-07 |
| AU7073174A (en) | 1976-01-08 |
| ES428107A1 (es) | 1976-11-16 |
| FR2236499B1 (enrdf_load_stackoverflow) | 1977-04-15 |
| SE417316B (sv) | 1981-03-09 |
| CH605919A5 (enrdf_load_stackoverflow) | 1978-10-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1440722A (en) | 2-1-piperazinyl-quinoxaline compounds having pharmaceutical activity | |
| NZ504203A (en) | Pleuromutilin derivatives as antimicrobials | |
| MY101268A (en) | Naphthalene derivatives, process for the preparation thereof and pharmaceutical composition containing same | |
| ZA966314B (en) | N-(aroyl)glycine hydroxamic acid derivatives and related compounds. | |
| HUT66971A (en) | 4-amino-naphthyridine derivatives pharmaceutical compositions containing the same and process for the production of thereof | |
| EP0326307A3 (en) | Novel pyridazinone derivatives and pharmaceutical preparations containing them | |
| GB1374283A (en) | Benzothiazine benzoxazine and indoline derivatives | |
| GB1307205A (en) | Isoindoline derivatives | |
| IL26473A (en) | 4,1-Bis- (4-pyrimidylamino-alkyl) piperazines and process for their production | |
| GB1301243A (enrdf_load_stackoverflow) | ||
| GB1530412A (en) | Pyrimidinylureas | |
| GB1476698A (en) | Quinazolinone derivatives and therapeutic compositions containing them | |
| DE69223769D1 (en) | Diphenylylchinuclidine als squalen-synthetase-inhibitoren | |
| GB1449861A (en) | Benzodiazepine and benzodiazocine derivatives | |
| GB1449802A (en) | Piperazine derivatives and compositions containing them for treating parkinsons disease | |
| GB1299151A (en) | 7-phenylpyrimido-benzodiazepine derivatives | |
| GB1361368A (en) | Pyrido 4,3-c pyridazine compounds | |
| GB1515063A (en) | Antibacterial quinoxaline 1,4-dioxides | |
| DE3666588D1 (en) | Spiroûbenzofuran-2(3h), 1'cycloheptane¨s, a process and intermediates for their preparation and their use as medicaments | |
| GB1342753A (en) | Dihydronaphthalene derivatives and higher or lower bicyclo homologues thereof and the preparation thereof | |
| ES8405021A1 (es) | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. | |
| IE46688B1 (en) | N-(2,3 -dihydro-9-ergolen-8 -yl methyl)ureas | |
| GB1531091A (en) | Pharmaceutical combination preparations | |
| GB1334125A (en) | Aminopropionanilides and a process for the preparation thereof | |
| GB1327552A (en) | 1-substituted benzyl tetrahydro-2-1h-pyrimidones and their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |