GB1436893A - Tetrahydrocarbazole derivatives and process for their manufa cture - Google Patents
Tetrahydrocarbazole derivatives and process for their manufa ctureInfo
- Publication number
- GB1436893A GB1436893A GB2279573A GB2279573A GB1436893A GB 1436893 A GB1436893 A GB 1436893A GB 2279573 A GB2279573 A GB 2279573A GB 2279573 A GB2279573 A GB 2279573A GB 1436893 A GB1436893 A GB 1436893A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- esters
- conh
- cyclohexanone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19722226703 DE2226703A1 (de) | 1972-05-25 | 1972-05-25 | Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1436893A true GB1436893A (en) | 1976-05-26 |
Family
ID=5846530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2279573A Expired GB1436893A (en) | 1972-05-25 | 1973-05-14 | Tetrahydrocarbazole derivatives and process for their manufa cture |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS4941367A (cs) |
AT (1) | AT323155B (cs) |
AU (1) | AU5607873A (cs) |
BE (1) | BE800066A (cs) |
CA (1) | CA1005062A (cs) |
CH (1) | CH582144A5 (cs) |
CS (1) | CS179416B2 (cs) |
DD (1) | DD106170A5 (cs) |
DE (1) | DE2226703A1 (cs) |
FR (1) | FR2185414B1 (cs) |
GB (1) | GB1436893A (cs) |
NL (1) | NL7307313A (cs) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005033113A2 (en) * | 2003-10-02 | 2005-04-14 | Cephalon, Inc | Indole derivatives |
EP1677794A2 (en) * | 2003-09-12 | 2006-07-12 | Elixir Pharmaceuticals, Inc. | Methods of treating disorder |
US7105560B1 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
US7105561B2 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac for the treatment of prostate cancer |
US7122570B2 (en) * | 2001-12-14 | 2006-10-17 | Zentaris Ag | Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR) |
US7129262B2 (en) | 1999-07-23 | 2006-10-31 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7151100B1 (en) | 1999-07-23 | 2006-12-19 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7211599B2 (en) | 2002-09-19 | 2007-05-01 | The Regents Of The University Of California | Use of etodolac to treat hyperplasia |
EP1793817A2 (en) * | 2004-09-13 | 2007-06-13 | Elixir Pharmaceuticals, Inc. | Methods of treating a disorder |
US7361680B2 (en) | 1999-07-23 | 2008-04-22 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
WO2010011316A1 (en) * | 2008-07-23 | 2010-01-28 | Arena Pharmaceuticals, Inc. | SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS |
US8415484B2 (en) | 2008-08-27 | 2013-04-09 | Arena Pharmaceuticals, Inc. | Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
US8853419B2 (en) | 2010-01-27 | 2014-10-07 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
US9085581B2 (en) | 2010-03-03 | 2015-07-21 | Arena Pharmaceuticals, Inc. | Processes for the preparation of S1P1 receptor modulators and crystalline forms thereof |
US10301262B2 (en) | 2015-06-22 | 2019-05-28 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders |
US11007175B2 (en) | 2015-01-06 | 2021-05-18 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
CN114634442A (zh) * | 2022-04-02 | 2022-06-17 | 内蒙古民族大学 | 一种四氢咔唑酮化合物的制备方法 |
US11478448B2 (en) | 2017-02-16 | 2022-10-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
US11534424B2 (en) | 2017-02-16 | 2022-12-27 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235903A (en) * | 1979-08-06 | 1980-11-25 | American Home Products Corporation | 1-Hydroxyalkanamine tetrahydrocarbazoles and cyclopent[b]indoles, compositions and method of use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH586678A5 (cs) * | 1970-05-25 | 1977-04-15 | Hoffmann La Roche | |
ZA715217B (en) * | 1970-08-20 | 1972-04-26 | Org Nv | Anti-inflammatory preparations |
-
1972
- 1972-05-25 DE DE19722226703 patent/DE2226703A1/de active Pending
-
1973
- 1973-04-17 DD DD17023273A patent/DD106170A5/xx unknown
- 1973-05-14 GB GB2279573A patent/GB1436893A/en not_active Expired
- 1973-05-16 CS CS350973A patent/CS179416B2/cs unknown
- 1973-05-17 CH CH707473A patent/CH582144A5/xx not_active IP Right Cessation
- 1973-05-23 AT AT449173A patent/AT323155B/de not_active IP Right Cessation
- 1973-05-24 AU AU56078/73A patent/AU5607873A/en not_active Expired
- 1973-05-25 BE BE131549A patent/BE800066A/xx unknown
- 1973-05-25 CA CA172,234A patent/CA1005062A/en not_active Expired
- 1973-05-25 JP JP5848173A patent/JPS4941367A/ja active Pending
- 1973-05-25 NL NL7307313A patent/NL7307313A/xx not_active Application Discontinuation
- 1973-05-25 FR FR7319087A patent/FR2185414B1/fr not_active Expired
Cited By (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7129262B2 (en) | 1999-07-23 | 2006-10-31 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7361680B2 (en) | 1999-07-23 | 2008-04-22 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7189752B2 (en) | 1999-07-23 | 2007-03-13 | Carson Dennis A | Use of etodolac for the treatment of chronic lymphocytic leukemia |
US7151100B1 (en) | 1999-07-23 | 2006-12-19 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
US7105560B1 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac in the treatment of multiple myeloma |
US7105561B2 (en) | 1999-07-23 | 2006-09-12 | The Regents Of The University Of California | Use of etodolac for the treatment of prostate cancer |
US7122570B2 (en) * | 2001-12-14 | 2006-10-17 | Zentaris Ag | Tetrahydrocarbazol derivatives as ligands for G-protein-coupled receptors (GPCR) |
US7211599B2 (en) | 2002-09-19 | 2007-05-01 | The Regents Of The University Of California | Use of etodolac to treat hyperplasia |
EP1677794A2 (en) * | 2003-09-12 | 2006-07-12 | Elixir Pharmaceuticals, Inc. | Methods of treating disorder |
EP1677794A4 (en) * | 2003-09-12 | 2010-05-19 | Elixir Pharmaceuticals Inc | METHODS OF TREATING DISORDERS |
US8486990B2 (en) | 2003-09-12 | 2013-07-16 | Elixir Pharmaceuticals, Inc. | SirT inhibitors that bind to NAD |
WO2005033113A3 (en) * | 2003-10-02 | 2005-06-30 | Salmedix Inc | Indole derivatives |
WO2005033112A3 (en) * | 2003-10-02 | 2005-06-09 | Salmedix Inc | Substituted indole derivatives |
WO2005033113A2 (en) * | 2003-10-02 | 2005-04-14 | Cephalon, Inc | Indole derivatives |
US7314886B2 (en) | 2003-10-02 | 2008-01-01 | Cephalon, Inc. | Tetrahydropyrano-indole derivatives |
WO2005033112A2 (en) * | 2003-10-02 | 2005-04-14 | Cephalon, Inc. | Substituted indole derivatives |
US7446122B2 (en) | 2003-10-02 | 2008-11-04 | Cephalon, Inc. | Substituted indole derivatives |
EP1793817A4 (en) * | 2004-09-13 | 2008-04-02 | Elixir Pharmaceuticals Inc | METHODS OF TREATING A DISEASE |
EP1793817A2 (en) * | 2004-09-13 | 2007-06-13 | Elixir Pharmaceuticals, Inc. | Methods of treating a disorder |
US8580841B2 (en) | 2008-07-23 | 2013-11-12 | Arena Pharmaceuticals, Inc. | Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
US9522133B2 (en) | 2008-07-23 | 2016-12-20 | Arena Pharmaceuticals, Inc. | Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
WO2010011316A1 (en) * | 2008-07-23 | 2010-01-28 | Arena Pharmaceuticals, Inc. | SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS |
EA019252B1 (ru) * | 2008-07-23 | 2014-02-28 | Арена Фармасьютикалз, Инк. | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ (1,2,3,4-ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛ-3-ИЛ)УКСУСНОЙ КИСЛОТЫ, ПРИМЕНИМЫЕ В ЛЕЧЕНИИ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ РАССТРОЙСТВ |
CN102164891B (zh) * | 2008-07-23 | 2014-09-03 | 艾尼纳制药公司 | 可用于治疗自身免疫性疾病和炎性疾病的经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物 |
CN104311472A (zh) * | 2008-07-23 | 2015-01-28 | 艾尼纳制药公司 | 经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物 |
CN104311472B9 (zh) * | 2008-07-23 | 2020-03-17 | 艾尼纳制药公司 | 经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物 |
US9126932B2 (en) | 2008-07-23 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
CN104311472B (zh) * | 2008-07-23 | 2019-12-31 | 艾尼纳制药公司 | 经取代的1,2,3,4-四氢环戊并[b]吲哚-3-基乙酸衍生物 |
JP2016029067A (ja) * | 2008-07-23 | 2016-03-03 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 自己免疫障害および炎症性障害の処置において有用な置換型1,2,3,4−テトラヒドロシクロペンタ[b]インドル−3−イル)酢酸誘導体 |
US8415484B2 (en) | 2008-08-27 | 2013-04-09 | Arena Pharmaceuticals, Inc. | Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
US9108969B2 (en) | 2008-08-27 | 2015-08-18 | Arena Pharmaceuticals, Inc. | Substituted tricyclic acid derivatives as S1P1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
US8853419B2 (en) | 2010-01-27 | 2014-10-07 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
US11149292B2 (en) | 2010-01-27 | 2021-10-19 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof |
US9175320B2 (en) | 2010-01-27 | 2015-11-03 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof |
US9447041B2 (en) | 2010-01-27 | 2016-09-20 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (R)-2-(7-4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[B]indol-3-yl)acetic acid and salts thereof |
US11674163B2 (en) | 2010-01-27 | 2023-06-13 | Arena Pharmaceuticals, Inc. | Processes for the preparation of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
US9085581B2 (en) | 2010-03-03 | 2015-07-21 | Arena Pharmaceuticals, Inc. | Processes for the preparation of S1P1 receptor modulators and crystalline forms thereof |
US11896578B2 (en) | 2015-01-06 | 2024-02-13 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
US11007175B2 (en) | 2015-01-06 | 2021-05-18 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
US10676435B2 (en) | 2015-06-22 | 2020-06-09 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compound 1) for use in SIPI receptor-associated disorders |
US11091435B2 (en) | 2015-06-22 | 2021-08-17 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3, 4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(compound1) for use in S1P1 receptor-associated disorders |
US11884626B2 (en) | 2015-06-22 | 2024-01-30 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compound1) for use in S1P1 receptor-associated disorders |
US10301262B2 (en) | 2015-06-22 | 2019-05-28 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders |
US11478448B2 (en) | 2017-02-16 | 2022-10-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
US11534424B2 (en) | 2017-02-16 | 2022-12-27 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
CN114634442A (zh) * | 2022-04-02 | 2022-06-17 | 内蒙古民族大学 | 一种四氢咔唑酮化合物的制备方法 |
CN114634442B (zh) * | 2022-04-02 | 2023-10-13 | 内蒙古民族大学 | 一种四氢咔唑酮化合物的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CS179416B2 (en) | 1977-10-31 |
BE800066A (fr) | 1973-11-26 |
CA1005062A (en) | 1977-02-08 |
DE2226703A1 (de) | 1973-12-13 |
NL7307313A (cs) | 1973-11-27 |
FR2185414B1 (cs) | 1976-08-13 |
FR2185414A1 (cs) | 1974-01-04 |
JPS4941367A (cs) | 1974-04-18 |
AT323155B (de) | 1975-06-25 |
CH582144A5 (cs) | 1976-11-30 |
AU5607873A (en) | 1974-11-28 |
DD106170A5 (cs) | 1974-06-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |