GB1426061A - Polypeptides - Google Patents
PolypeptidesInfo
- Publication number
- GB1426061A GB1426061A GB438773*[A GB438773A GB1426061A GB 1426061 A GB1426061 A GB 1426061A GB 438773 A GB438773 A GB 438773A GB 1426061 A GB1426061 A GB 1426061A
- Authority
- GB
- United Kingdom
- Prior art keywords
- insulin
- lys
- ala
- protease
- des
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 101001011741 Bos taurus Insulin Proteins 0.000 abstract 1
- 102000005593 Endopeptidases Human genes 0.000 abstract 1
- 108010059378 Endopeptidases Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- QOOWRKBDDXQRHC-BQBZGAKWSA-N L-lysyl-L-alanine Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN QOOWRKBDDXQRHC-BQBZGAKWSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 241001544324 Myxobacter Species 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 108010005991 Pork Regular Insulin Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 101710180316 Protease 2 Proteins 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 229920005654 Sephadex Polymers 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- IXIBAKNTJSCKJM-BUBXBXGNSA-N bovine insulin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 IXIBAKNTJSCKJM-BUBXBXGNSA-N 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
- 230000002608 insulinlike Effects 0.000 abstract 1
- 239000002808 molecular sieve Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920002401 polyacrylamide Polymers 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB438773*[A GB1426061A (en) | 1972-12-28 | 1973-01-29 | Polypeptides |
| IE2122/73A IE38539B1 (en) | 1972-12-28 | 1973-11-22 | Polypeptides |
| CA186,556A CA1009974A (en) | 1972-12-28 | 1973-11-23 | Des-lys29-ala30-insulin and production thereof |
| AU62979/73A AU474971B2 (en) | 1972-12-28 | 1973-11-28 | Polypeptides |
| US420573A US3903069A (en) | 1972-12-28 | 1973-11-30 | Polypeptides obtained by modification of porcine or bovine insulin |
| IL43751A IL43751A (en) | 1972-12-28 | 1973-12-04 | Des-lys29-ala30-insulins and their preparation |
| CH1759373A CH599927A5 (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-14 | |
| NL7317159A NL7317159A (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-14 | |
| PL1973167350A PL91158B1 (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-15 | |
| SE7317256A SE404600B (sv) | 1972-12-28 | 1973-12-20 | Sett att framstella des-(lys29-ala30)-porcin-insulin och des-(lys29-ala30)-bovin-insulin |
| DD175618A DD110490A5 (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-21 | |
| JP744631A JPS5726760B2 (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-26 | |
| AT1084473A AT348152B (de) | 1972-12-28 | 1973-12-27 | Verfahren zur herstellung von neuen polypeptiden |
| LU69075A LU69075A1 (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-27 | |
| FR7346550A FR2212136B1 (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-27 | |
| DE2364883A DE2364883C2 (de) | 1972-12-28 | 1973-12-28 | Des-Lys↑2↑↑9↑-Ala↑3↑↑0↑-Schweine- und -Rinderinsulin, Verfahren zu deren Herstellung und diese Insuline enthaltende injizierbare Präparate |
| ES421864A ES421864A1 (es) | 1972-12-28 | 1973-12-28 | Procedimiento para preparar insulinas des-lis29-ala30-por- cina y bovina. |
| HUIE605A HU170437B (enrdf_load_stackoverflow) | 1972-12-28 | 1973-12-28 | |
| US05/573,027 US3989821A (en) | 1972-12-18 | 1975-04-30 | Polypeptides |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5974272 | 1972-12-28 | ||
| GB438773*[A GB1426061A (en) | 1972-12-28 | 1973-01-29 | Polypeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1426061A true GB1426061A (en) | 1976-02-25 |
Family
ID=26239087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB438773*[A Expired GB1426061A (en) | 1972-12-18 | 1973-01-29 | Polypeptides |
Country Status (18)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1983002772A1 (en) * | 1982-02-08 | 1983-08-18 | Robin Ewart Offord | An improved method for preparing human insulin from non-human insulin |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55138391A (en) * | 1979-04-13 | 1980-10-29 | Shionogi & Co Ltd | New synthetic method of peptide derivative |
| DE3064479D1 (en) * | 1979-04-13 | 1983-09-08 | Shionogi & Co | Process for preparing a b30-threonine insulin |
| DE3209184A1 (de) * | 1982-03-13 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen |
| GB8610551D0 (en) * | 1986-04-30 | 1986-06-04 | Hoffmann La Roche | Polypeptide & protein derivatives |
| US6673347B1 (en) * | 1986-04-30 | 2004-01-06 | Gryphon Therapeutics | Polypeptide and protein derivatives and process for their preparation |
| PH23446A (en) * | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
| HUT56857A (en) * | 1988-12-23 | 1991-10-28 | Novo Nordisk As | Human insulin analogues |
| US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH471220A (de) * | 1964-05-09 | 1969-04-15 | Roehm & Haas Gmbh | Verfahren zur Herstellung einer L-Leucinamid, Hypertensin und Oxytocin spaltenden Aminopeptidase |
-
1973
- 1973-01-29 GB GB438773*[A patent/GB1426061A/en not_active Expired
- 1973-11-22 IE IE2122/73A patent/IE38539B1/xx unknown
- 1973-11-23 CA CA186,556A patent/CA1009974A/en not_active Expired
- 1973-11-28 AU AU62979/73A patent/AU474971B2/en not_active Expired
- 1973-11-30 US US420573A patent/US3903069A/en not_active Expired - Lifetime
- 1973-12-04 IL IL43751A patent/IL43751A/en unknown
- 1973-12-14 NL NL7317159A patent/NL7317159A/xx unknown
- 1973-12-14 CH CH1759373A patent/CH599927A5/xx not_active IP Right Cessation
- 1973-12-15 PL PL1973167350A patent/PL91158B1/pl unknown
- 1973-12-20 SE SE7317256A patent/SE404600B/xx unknown
- 1973-12-21 DD DD175618A patent/DD110490A5/xx unknown
- 1973-12-26 JP JP744631A patent/JPS5726760B2/ja not_active Expired
- 1973-12-27 AT AT1084473A patent/AT348152B/de not_active IP Right Cessation
- 1973-12-27 FR FR7346550A patent/FR2212136B1/fr not_active Expired
- 1973-12-27 LU LU69075A patent/LU69075A1/xx unknown
- 1973-12-28 ES ES421864A patent/ES421864A1/es not_active Expired
- 1973-12-28 DE DE2364883A patent/DE2364883C2/de not_active Expired
- 1973-12-28 HU HUIE605A patent/HU170437B/hu unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1983002772A1 (en) * | 1982-02-08 | 1983-08-18 | Robin Ewart Offord | An improved method for preparing human insulin from non-human insulin |
| EP0087238A1 (en) * | 1982-02-08 | 1983-08-31 | Biogen N.V. | Am improved method for preparing human insulin from non-human insulin |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4994698A (enrdf_load_stackoverflow) | 1974-09-09 |
| JPS5726760B2 (enrdf_load_stackoverflow) | 1982-06-07 |
| ES421864A1 (es) | 1976-08-01 |
| FR2212136A1 (enrdf_load_stackoverflow) | 1974-07-26 |
| IL43751A (en) | 1977-01-31 |
| ATA1084473A (de) | 1978-06-15 |
| IL43751A0 (en) | 1974-03-14 |
| DE2364883C2 (de) | 1984-07-19 |
| AU6297973A (en) | 1975-05-29 |
| NL7317159A (enrdf_load_stackoverflow) | 1974-07-02 |
| CH599927A5 (enrdf_load_stackoverflow) | 1978-06-15 |
| PL91158B1 (enrdf_load_stackoverflow) | 1977-02-28 |
| US3903069A (en) | 1975-09-02 |
| AU474971B2 (en) | 1976-08-05 |
| DD110490A5 (enrdf_load_stackoverflow) | 1974-12-20 |
| DE2364883A1 (de) | 1974-07-04 |
| IE38539B1 (en) | 1978-04-12 |
| FR2212136B1 (enrdf_load_stackoverflow) | 1978-01-06 |
| SE404600B (sv) | 1978-10-16 |
| HU170437B (enrdf_load_stackoverflow) | 1977-06-28 |
| CA1009974A (en) | 1977-05-10 |
| IE38539L (en) | 1974-06-28 |
| LU69075A1 (enrdf_load_stackoverflow) | 1974-03-07 |
| AT348152B (de) | 1979-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |