GB1415295A - Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof - Google Patents

Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof

Info

Publication number
GB1415295A
GB1415295A GB4792771A GB4792771A GB1415295A GB 1415295 A GB1415295 A GB 1415295A GB 4792771 A GB4792771 A GB 4792771A GB 4792771 A GB4792771 A GB 4792771A GB 1415295 A GB1415295 A GB 1415295A
Authority
GB
United Kingdom
Prior art keywords
alkyl
halo
alkoxy
agents
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4792771A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orchimed SA
Original Assignee
Orchimed SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE2003430A priority Critical patent/DE2003430C3/de
Application filed by Orchimed SA filed Critical Orchimed SA
Priority to GB4792771A priority patent/GB1415295A/en
Priority to FR7236165A priority patent/FR2157853B2/fr
Priority to DE2250327A priority patent/DE2250327C2/de
Priority to BE790026D priority patent/BE790026R/xx
Publication of GB1415295A publication Critical patent/GB1415295A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB4792771A 1969-01-31 1971-10-14 Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof Expired GB1415295A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE2003430A DE2003430C3 (de) 1969-01-31 1970-01-27 p-Benzoylphenoxyisobuttersäureester, ihre Herstellung und diese enthaltende Arzneimittel
GB4792771A GB1415295A (en) 1971-10-14 1971-10-14 Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof
FR7236165A FR2157853B2 (enrdf_load_stackoverflow) 1971-10-14 1972-10-12
DE2250327A DE2250327C2 (de) 1969-01-31 1972-10-13 Phenoxyibuttersäurederivate, ihre Säureadditionssalze, Verfahren zu deren Herstellung und pharmazeutische Mittel
BE790026D BE790026R (fr) 1969-01-31 1972-10-13 Procede de preparation de corps derives de l'acide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB4792671 1971-10-14
GB4792771A GB1415295A (en) 1971-10-14 1971-10-14 Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
GB1415295A true GB1415295A (en) 1975-11-26

Family

ID=26266167

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4792771A Expired GB1415295A (en) 1969-01-31 1971-10-14 Substituted phenoxy-alkyl-carboxylic acids and derivatives thereof

Country Status (2)

Country Link
FR (1) FR2157853B2 (enrdf_load_stackoverflow)
GB (1) GB1415295A (enrdf_load_stackoverflow)

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242358A (en) * 1979-01-24 1980-12-30 Societe De Recherches Industrielles (Sori) Method of treatment of algiae
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
US4801616A (en) * 1986-03-25 1989-01-31 Eli Lilly And Company Diphenylmethanone compounds and anti-inflammatory use thereof
US4853404A (en) * 1986-10-13 1989-08-01 Tanabe Seiyaku Co., Ltd. Phenoxyacetic acid derivatives composition and use
US6013839A (en) * 1996-02-15 2000-01-11 Rhone-Poulenc Agriculture Limited Process for preparing 2-(thiosubstituted)-4-haloacetophenones
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7030106B2 (en) 2001-01-26 2006-04-18 Schering Corporation Sterol absorption inhibitor compositions
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US7132415B2 (en) 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US7192944B2 (en) 2003-03-07 2007-03-20 Schering Corp. Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2006135480A3 (en) * 2005-04-08 2007-04-05 Abbott Lab Oral pharmaceutical formulations comprising fenofibric acid and/or its salts
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7417039B2 (en) 2001-01-26 2008-08-26 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7560449B2 (en) 2002-11-06 2009-07-14 Schering Corporation Methods and therapeutic combinations for the treatment of demyelination
US20100185008A1 (en) * 2007-07-05 2010-07-22 Finorga Method for Producing Fenofibrate
WO2012055014A1 (en) 2010-10-27 2012-05-03 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
CN107261149A (zh) * 2008-12-04 2017-10-20 于崇曦 高穿透性组合物及其应用
WO2021019493A1 (en) 2019-07-31 2021-02-04 Intas Pharmaceuticals Ltd. Pharmaceutical composition comprising hmg-coa reductase inhibitors and fenofibrate

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1517603A (en) * 1976-04-02 1978-07-12 Lafon Labor Esters of 2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl-propionic acid with bis-(hydroxyalkylthio)-alkanes
GB1520602A (en) * 1976-04-02 1978-08-09 Lafon Labor Esters of bis-(hydroxyalkylthio)-alkanes
GB2025942A (en) * 1978-05-31 1980-01-30 Sori Soc Rech Ind Phenoxyalkylcarboxylic acids
FR2494112B1 (enrdf_load_stackoverflow) * 1980-11-19 1986-01-10 Laruelle Claude
FR2886844B1 (fr) * 2005-06-09 2007-09-14 Oreal Utilisation de composes 2-oxy-acetamide pour favoriser et/ou induire et/ou stimuler la pigmentation des matieres keratiniques et/ou limiter leur depigmentation et/ou leur blanchiment
FR2918367A1 (fr) * 2007-07-05 2009-01-09 Finorga Soc Par Actions Simpli Procede de preparation du fenofibrate
FR2918662B1 (fr) * 2007-07-10 2009-10-30 Finorga Soc Par Actions Simpli Procede de preparation du fenofibrate
MX2022015336A (es) 2020-09-29 2023-01-11 Laboratorios Silanes S A De C V Combinaciones farmaceuticas de estatinas y fibratos para el tratamiento y prevencion de hiperlipidemias y enfermedades cardiovasculares.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3379755A (en) * 1964-06-04 1968-04-23 Merck & Co Inc Preparation of (4-alkanoylphenoxy) acetic acids by oxidation
FR4963M (enrdf_load_stackoverflow) * 1965-09-15 1967-05-08
CH528101A (de) * 1970-03-11 1972-09-15 Ciba Geigy Ag Verwendung von 2-Hydroxybenzophenonen als Stabilisierungsmittel gegen Ultraviolettstrahlung in farbphotographischem Material

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242358A (en) * 1979-01-24 1980-12-30 Societe De Recherches Industrielles (Sori) Method of treatment of algiae
US4661505A (en) * 1982-11-03 1987-04-28 Eli Lilly And Company Leukotriene antagonists
US4801616A (en) * 1986-03-25 1989-01-31 Eli Lilly And Company Diphenylmethanone compounds and anti-inflammatory use thereof
US4853404A (en) * 1986-10-13 1989-08-01 Tanabe Seiyaku Co., Ltd. Phenoxyacetic acid derivatives composition and use
US6013839A (en) * 1996-02-15 2000-01-11 Rhone-Poulenc Agriculture Limited Process for preparing 2-(thiosubstituted)-4-haloacetophenones
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7030106B2 (en) 2001-01-26 2006-04-18 Schering Corporation Sterol absorption inhibitor compositions
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
US7612058B2 (en) 2001-01-26 2009-11-03 Schering Corporation Methods for inhibiting sterol absorption
US7417039B2 (en) 2001-01-26 2008-08-26 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US7132415B2 (en) 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US7560449B2 (en) 2002-11-06 2009-07-14 Schering Corporation Methods and therapeutic combinations for the treatment of demyelination
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7732413B2 (en) 2003-03-07 2010-06-08 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7368563B2 (en) 2003-03-07 2008-05-06 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7368562B2 (en) 2003-03-07 2008-05-06 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7378518B2 (en) 2003-03-07 2008-05-27 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7235543B2 (en) 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7208486B2 (en) 2003-03-07 2007-04-24 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7741289B2 (en) 2003-03-07 2010-06-22 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7192944B2 (en) 2003-03-07 2007-03-20 Schering Corp. Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EA023376B1 (ru) * 2005-04-08 2016-05-31 Эббот Лабораториз Твердая дозированная форма и содержащая ее упаковка для комбинированной терапии
NO20075628L (no) * 2005-04-08 2007-11-05 Bgp Products Ireland Ltd Farmasøytiske formuleringer
WO2006135480A3 (en) * 2005-04-08 2007-04-05 Abbott Lab Oral pharmaceutical formulations comprising fenofibric acid and/or its salts
NO343548B1 (no) * 2005-04-08 2019-04-01 Bgp Products Ireland Ltd Farmasøytiske formuleringer
US20100185008A1 (en) * 2007-07-05 2010-07-22 Finorga Method for Producing Fenofibrate
CN111808011A (zh) * 2008-12-04 2020-10-23 于崇曦 高穿透性组合物及其应用
CN108191846B (zh) * 2008-12-04 2021-08-20 于崇曦 高穿透性组合物及其应用
CN111808011B (zh) * 2008-12-04 2024-02-27 泰飞尔生物医药(苏州)有限公司 高穿透性组合物及其应用
US11541029B2 (en) 2008-12-04 2023-01-03 Techfields Pharma Co., Ltd. High penetration compositions and their applications
CN107261149A (zh) * 2008-12-04 2017-10-20 于崇曦 高穿透性组合物及其应用
CN108191846A (zh) * 2008-12-04 2018-06-22 于崇曦 高穿透性组合物及其应用
CN113636965A (zh) * 2008-12-04 2021-11-12 于崇曦 高穿透性组合物及其应用
KR20130140745A (ko) * 2010-10-27 2013-12-24 프로메틱 바이오사이언시즈 인코포레이티드 페닐케톤 카복실레이트 화합물 및 그의 약제학적 용도
WO2012055014A1 (en) 2010-10-27 2012-05-03 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
EA022988B1 (ru) * 2010-10-27 2016-04-29 Прометик Биосайнсиз Инк. Соединения фенилкетонкарбоксилата и их фармацевтическое применение
KR101870468B1 (ko) 2010-10-27 2018-06-22 프로메틱 파마 에스엠티 리미티드 페닐케톤 카복실레이트 화합물 및 그의 약학 용도
US9475750B2 (en) 2010-10-27 2016-10-25 Prometic Biosciences Inc. Phenylketone carboxylate compounds and pharmaceutical uses thereof
EA022988B9 (ru) * 2010-10-27 2016-08-31 Прометик Биосайнсиз Инк. Соединения фенилкетонкарбоксилата и их фармацевтическое применение
WO2021019493A1 (en) 2019-07-31 2021-02-04 Intas Pharmaceuticals Ltd. Pharmaceutical composition comprising hmg-coa reductase inhibitors and fenofibrate
EP4115879A1 (en) 2019-07-31 2023-01-11 Intas Pharmaceuticals Ltd. Pharmaceutical composition comprising hmg-coa reductase inhibitors and fenofibrate

Also Published As

Publication number Publication date
FR2157853A2 (enrdf_load_stackoverflow) 1973-06-08
FR2157853B2 (enrdf_load_stackoverflow) 1975-11-28

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PE20 Patent expired after termination of 20 years